A5100683927- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Sperm and Testicular Function
- Endoplasmic Reticulum Stress and Disease
- Gynecological conditions and treatments
- Cancer-related molecular mechanisms research
- Cardiac Imaging and Diagnostics
- Extracellular vesicles in disease
- Thermal and Kinetic Analysis
- Uterine Myomas and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Pelvic floor disorders treatments
- Cellular Mechanics and Interactions
- RNA modifications and cancer
- Inorganic and Organometallic Chemistry
- Hernia repair and management
- Neuroinflammation and Neurodegeneration Mechanisms
- Photosynthetic Processes and Mechanisms
- Covalent Organic Framework Applications
- Plant Gene Expression Analysis
- ZnO doping and properties
- Cardiovascular Function and Risk Factors
- Crystallization and Solubility Studies
Zhejiang University
2022-2025
Lanzhou University
2022-2025
Shandong Marine Resource and Environment Research Institute
2018-2025
Sichuan University
2024-2025
West China Hospital of Sichuan University
2024-2025
Changchun University of Chinese Medicine
2025
Institute of Soil Science
2025
Chinese Academy of Sciences
2021-2025
University of Chinese Academy of Sciences
2021-2025
Nanjing Forestry University
2025
As a critical radioactive anionic contaminant, traditional adsorbents primarily remove iodate (IO
Abstract The role of cis -elements and their aberrations remains unclear in esophageal squamous cell carcinoma (ESCC, further abbreviated EC). Here we survey 28 H3K27ac-marked active enhancer profiles 50 transcriptomes primary EC, metastatic lymph node cancer (LNC), adjacent normal (Nor) tissues. Thousands gained or lost enhancers hundreds altered putative super-enhancers are identified EC LNC samples respectively relative to Nor, with a large number common enhancers. Moreover, these...
The mitogen-activated protein kinase 18 (MAPKKK18) has been reported to play a role in abiotic stress priming long-term abscisic acid (ABA) response including drought tolerance and leaf senescence. However, the upstream transcriptional regulators of MAPKKK18 remain be determined. Here, we report ABA-responsive element binding factors (ABFs) as transcription expression. Mutants abf2, abf3, abf4, abf2abf3abf4 dramatically reduced MAPKKK18. Our electrophoresis mobility shift assay...
Long noncoding RNAs (lncRNAs) have emerged as important components of gene regulatory network in embryonic stem cells (ESCs). However, the function and molecular mechanism lncRNAs are still largely unknown. Here we identifies Trincr1 (TRIM71 interacting long RNA 1) lncRNA that regulates FGF/ERK signaling self-renewal ESCs. is exported by THOC complex to cytoplasm where it binds represses TRIM71, leading downregulation SHCBP1 protein. Knocking out leads upregulation phosphorylated ERK pathway...
Abstract Integration of metal–organic frameworks on deformation tolerant substrates exhibits a promising prospect in flexible electrode applications. A straightforward synthesis utilizing atomic layer deposition pretreating to induce the growth zeolitic imidazolate framework‐67 (ZIF‐67) carbon foam (CF), which maintains high ZIF‐67 loading with hierarchically porous structure and large surface area 453 m 2 g −1 is presented. With subsequent pyrolysis process, three‐dimensional composite...
Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to lack of actionable therapeutic targets. Herein we define lysosomal acid lipase A (LIPA) as viable molecular target in TNBC and identify stereospecific small molecule (ERX-41) that binds LIPA. ERX-41 induces endoplasmic reticulum (ER) stress resulting cell death, this effect is on evidenced by specific LIPA mutations providing resistance. Importantly, demonstrate activity independent function but dependent its ER...
Abstract Klebsiella pneumoniae is a widespread pathogen of several human diseases. The emergence multidrug-resistant K. makes the treatment these diseases significant challenge. application bacteriophages potential approach for dealing with pathogenic bacteria. This study isolates novel bacteriophage vB_KleM_KB2 that infects clinical . exhibits short latent period 10 min, and can effectively lyse bacterium within 60 min. Notably, completely inhibit growth host at initial concentration 7...
TiO2 is a promising environment friendly, low cost, and high electrochemical performance material. However, impediments like internal ion resistance electrical conductivity restrict its applications as electrode for supercapacitor. In the present work, atomic layer deposition was used to fabricate nanomembranes (NMs) with accurately controlled thicknesses. The NMs were then electrodes high-performance pseudocapacitors. Experimental results demonstrated that NM 100 ALD cycles had highest...
A key mediator of macroautophagy/autophagy induction is the class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) consisting PIK3C3/VPS34, PIK3R4/VPS15, BECN1, and ATG14. Although several proteins are known to enhance or decrease PtdIns3K-C1 activity, our understanding molecular regulation still incomplete. Previously, we identified a Golgi-associated protein, GLIPR2, in screen for that interact with amino acids 267-284 region BECN1 sufficient induce autophagy when fused cell...