A5015807309- Autophagy in Disease and Therapy
- Mosquito-borne diseases and control
- Endoplasmic Reticulum Stress and Disease
- Toxoplasma gondii Research Studies
- Cannabis and Cannabinoid Research
- Calcium signaling and nucleotide metabolism
- Cell death mechanisms and regulation
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Cytomegalovirus and herpesvirus research
- Cancer-related gene regulation
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Herpesvirus Infections and Treatments
- Viral Infections and Outbreaks Research
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Plant responses to water stress
- Virology and Viral Diseases
- CRISPR and Genetic Engineering
- Cellular transport and secretion
- Phagocytosis and Immune Regulation
- Polyamine Metabolism and Applications
- Extracellular vesicles in disease
- Studies on Chitinases and Chitosanases
The University of Texas Southwestern Medical Center
2015-2024
Howard Hughes Medical Institute
2013-2022
Montavid Thermodynamic Research Group
2012-2021
Tisch Hospital
2019
Levine Cancer Institute
2017-2019
Southwestern Medical Center
2006-2017
National Yang Ming Chiao Tung University
2016
Kagoshima University
2016
Kyushu University
2016
Rutgers, The State University of New Jersey
2016
Although cachexia often accompanies advanced heart failure, little is known about the causes of cachectic state. To assess potential role tumor necrosis factor in pathogenesis cardiac cachexia, we measured serum levels 33 patients with chronic age-matched healthy controls, and 9 renal failure.
Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no genetic evidence a role of autophagy genes tumor suppression. The beclin 1 gene monoallelically deleted 40–75% cases human sporadic breast, ovarian, prostate cancer. Therefore, we used targeted mutant mouse model to test the hypothesis that monoallelic deletion promotes tumorigenesis. Here show heterozygous...
Autophagy is an intracellular bulk degradation process for proteins and organelles. In the heart, autophagy stimulated by myocardial ischemia. However, causative role of in survival cardiac myocytes underlying signaling mechanisms are poorly understood. Glucose deprivation (GD), which mimics ischemia, induces cultured myocytes. Survival was decreased 3-methyladenine, inhibitor autophagy, suggesting that protective against GD GD-induced coincided with activation AMP-activated protein kinase...
Both dauer formation (a stage of developmental arrest) and adult life-span in Caenorhabditis elegans are negatively regulated by insulin-like signaling, but little is known about cellular pathways that mediate these processes. Autophagy, through the sequestration delivery cargo to lysosomes, major route for degrading long-lived proteins cytoplasmic organelles eukaryotic cells. Using nematodes with a loss-of-function mutation signaling pathway, we show bec-1 , C. ortholog yeast mammalian...
ABSTRACT bcl-2 , the prototypic cellular antiapoptotic gene, decreases Sindbis virus replication and virus-induced apoptosis in mouse brains, resulting protection against lethal encephalitis. To investigate potential mechanisms by which Bcl-2 protects central nervous system infection, we performed a yeast two-hybrid screen to identify Bcl-2-interacting gene products an adult brain library. We identified novel 60-kDa coiled-coil protein, Beclin, confirmed interacts with mammalian cells, using...