A5004841728- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Polyamine Metabolism and Applications
- FOXO transcription factor regulation
- Circular RNAs in diseases
- Nuclear Structure and Function
- melanin and skin pigmentation
- PARP inhibition in cancer therapy
- Bone and Dental Protein Studies
- Liver physiology and pathology
- Plant Gene Expression Analysis
- Traditional and Medicinal Uses of Annonaceae
- Genetic factors in colorectal cancer
- Virus-based gene therapy research
- Cancer Mechanisms and Therapy
Chongqing Medical University
2021-2023
Shandong Provincial Hospital
2013-2021
Shandong University
2013-2021
Shandong First Medical University
2021
Central South University
2018-2020
First Affiliated Hospital of Fujian Medical University
2020
Fujian Medical University
2020
Fudan University
2011-2019
Shanghai Medical College of Fudan University
2015-2017
Nantong University
2015-2016
Abstract Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a poor prognosis. Circular RNA (circRNA) been increasingly recognized as crucial contributor to carcinogenesis. circRNA_0000140 aberrantly expressed in OSCC, but its role tumor growth metastasis remains largely unclear. Sanger sequencing, actinomycin D, RNase R treatments were used confirm head-to-tail junction sequences stability circ_0000140. In vitro activities, including proliferation, migration,...
Eukaryotic chromosomes are folded into higher-order conformations to coordinate genome functions. In addition long-range chromatin loops, recent chromosome conformation capture (3C)-based studies have indicated higher levels of structures including compartments and topologically associating domains (TADs), which may serve as units organization However, the molecular machinery underlying these hierarchically three-dimensional (3D) architectures remains poorly understood. Via high-throughput...
Cervical cancer is one of the most common gynecological malignancies with poor prognosis due to constant chemoresistance and repeated relapse. Ciclopirox olamine (CPX), a synthetic antifungal agent, has recently been identified be promising anti-cancer candidate. However, detailed mechanisms related its effects remain unclear need further elucidated. In this study, we found that CPX could induce proliferation inhibition in cervical cells by targeting PARK7. Further results demonstrated...
The tumor microenvironment is comprised of cancer cells and various stromal their respective cellular components. Cancer-associated fibroblasts (CAFs), a major part the cells, are key determinant in progression, while glucose-regulated protein (GRP)78 overexpressed many human cancers involved invasion metastasis. This study developed microfluidic-based three dimension (3D) co-culture device to mimic an vitro order investigate cell real-time. bionic chip provided significant information...
Coactivator-associated arginine methyltransferase 1 (CARM1) belongs to the protein family. CARM1 has been reported be associated with high grade tumors in breast cancer. It still remains unknown expression pattern of cancer and its relationships clinicopathological characteristics molecular subtypes.Two hundred forty-seven invasive cases were collected prepared for tissue array. There thirty-seven benign glandular epithelium adjacent among these cases. Molecular subtype investigated using...
Abstract In the interphase nucleus, chromatin is organized into three-dimensional conformation to coordinate genome functions. The lamina-chromatin association important facilitate higher-order in mammalian cells, but its biological significances and molecular mechanisms remain poorly understood. One obstacle that list of lamina-associated proteins remains limited, presumably due inherent insolubility lamina proteins. this report, we identified 182 associated with lamin B1 (a constitutive...
The architecture and function of chromatin are largely regulated by local interacting molecules, such as transcription factors noncoding RNAs.However, our understanding these regulatory molecules at a given locus is limited because technical difficulties.Here, we describe the use Clustered Regularly Interspaced Short Palindromic Repeats an engineered ascorbate peroxidase 2 (APEX2) system to investigate interactions (CAPLOCUS).We showed that with specific small-guide RNA targets, CAPLOCUS...
Hepatocellular carcinoma is one of the most common fatal malignancies worldwide. Thus far, hepatocellular prognosis has been bleak due to deficiencies in identification and diagnosis early carcinoma. Ciclopirox olamine (CPX) a synthetic antifungal agent considered as an anti-cancer candidate drug recently, though detailed mechanisms related its effect have not yet revealed. Here, we found that CPX could inhibit proliferation HCC cells but intrahepatic cholangiocarcinoma by arresting cell...
The nuclear matrix-associated protein Heterogeneous Nuclear Ribonucleoprotein U (HNRNPU), also known as SAF-A, is to maintain active chromatin structure in mouse hepatocytes. However, the functional roles and molecular mechanisms of HNRNPU development hepatocellular carcinoma (HCC) remain largely unknown. Herein, we found that was upregulated HCC, proliferation HCC cells inhibited vitro vivo upon knockdown. Moreover, upregulation correlated with poor prognosis HCC. Mechanistically, bound...
Abstract Hepatitis B virus infection remains a major health problem worldwide due to its high risk of liver failure and hepatocellular carcinoma. Covalently closed circular DNA (cccDNA), which is present as an individual minichromosome, serves the template for transcription all viral RNAs pla ays critical role in persistence. Therefore, there urgent need gain broader insight into regulation cccDNA. Here, we combined modified Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)...
Abstract The kidney ankyrin repeat‐containing protein 1 (Kank1) gene is one of the most important members KANK family. Kank1 has hybridity deletion and promoter methylation in cancer tissues brain, lung, corresponding cell lines, leading to downregulation expression. Meanwhile, also plays a key role occurrence development various types tumors, suggesting that may be an anti‐oncogene. However, its potential mechanisms Oral Squamous Cell Carcinoma (OSCC) remain unclear. We examined expression...
Nacre (mother of pearl) is a bioactive material capable facilitating osteoblast proliferation and differentiation; however, further investigation into the mechanism underlying effects nacre on stimulation bone differentiation required. The present study aimed to elucidate water‑soluble nano‑pearl powder (WSNNP) examine mechanisms. A MTT assay revealed that WSNNP (10, 25 50 µg/ml) may stimulate viability preosteoblastic MC3T3‑E1 cells µg/ml exhibited maximum stimulatory effect. Furthermore,...
p53-induced death domain protein (PIDD) facilitates p53-dependent apoptosis through the interaction with components of receptor signaling pathways. However, role PIDD in hepatocellular carcinoma (HCC) development remains unknown. In this study, we investigated expression pattern clinical HCC samples and adjacent non-cancerous tissues using immunohistochemistrical Western blot analyses. The results showed that was lowly expressed cell lines, compared non-tumorous LO2 normal hepatocytes....
The objective of the study is to provide an efficient and practical screening strategy distinguish a broader spectrum Lynch syndrome (LS) LS mimics-associated colorectal cancer (CRC), including Lynch-like (LLS), constitutional mismatch repair-deficiency, familial CRC type X (FCCTX), polymerase proofreading-associated polyposis syndrome.1294 cases samples were detected repair (MMR) status using immunohistochemistry (IHC) staining, in which with MLH1-deficient underwent BRAF mutation analysis...
Isolated peripheral blood mononuclear cells (PBMCs) from a healthy female were successfully transformed into induced pluripotent stem (iPSCs) by non-integrating episomal vectors containing OCT4, SOX2, c-MYC, KLF4, and BCL-XL. The iPSCs displayed normal karyotype, expressed pluripotency markers could differentiate three germ layers in vitro. This iPSC line may be subsequently used for further researches.
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)