A5102983858- Advanced Memory and Neural Computing
- Ferroelectric and Piezoelectric Materials
- Ferroelectric and Negative Capacitance Devices
- Magnetic properties of thin films
- Multiferroics and related materials
- Microwave Dielectric Ceramics Synthesis
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Magnetic Properties and Applications
- Semiconductor materials and devices
- Microfluidic and Capillary Electrophoresis Applications
- Millimeter-Wave Propagation and Modeling
- Mechanical and Optical Resonators
- ZnO doping and properties
- Physical Unclonable Functions (PUFs) and Hardware Security
- Precipitation Measurement and Analysis
- Electronic and Structural Properties of Oxides
- Ultra-Wideband Communications Technology
- Characterization and Applications of Magnetic Nanoparticles
- Integrated Circuits and Semiconductor Failure Analysis
- Magnetic Field Sensors Techniques
- Ocular and Laser Science Research
- Force Microscopy Techniques and Applications
- Dielectric properties of ceramics
- Biosensors and Analytical Detection
Zhongyuan University of Technology
2023-2025
Nanyang Institute of Technology
2025
Beijing Institute of Technology
2013-2024
Guangzhou Medical University
2024
Wuhan National Laboratory for Optoelectronics
2021-2024
Huazhong University of Science and Technology
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Hubei University
2020-2024
Lanzhou University
2020
Dalian Medical University
2013-2019
Metastasis is a complex pathophysiological process. As the main cause of cancer mortality in humans it represents serious challenge to both basic researchers and clinicians. Here we report design construction multi-organ microfluidic chip that closely mimics vivo microenvironment lung metastasis. This multi-organs-on-a-chip includes an upstream "lung" three downstream "distant organs", with polydimethylsiloxane (PDMS) layers two thin PDMS microporous membranes bonded form parallel...
Abstract The mechanism by which tumor-associated macrophages (TAMs) affect cancer progression is not fully understood. This study developed a microfluidic-based co-culture device to mimic the tumor microenvironment assess TAM effects on invasion and metastasis in NSCLC. results showed lung carcinoma cells could cause show M2 (a TAM-like) phenotype, these promoted cell EMT invasion. Proteomic analysis iTRAQ quantitation strategy GO ontology of indicated that αB-Crystallin (CRYAB) might be...
Tumor stroma and growth factors provide a survival environment to tumor cells can modulate their chemoresistance by dysregulating several signal pathways. In this study, we fabricated three-dimensional (3D) microfluidic chip using polydimethylsiloxane (PDMS) investigate the impact of hepatocyte factor (HGF) from cancer-associated fibroblasts (CAF) on Met/PI3K/AKT activation, glucose regulatory protein (GRP78) expression paclitaxel-induced A549 cell apoptosis. With concentration gradient...
The tumor microenvironment is comprised of cancer cells and various stromal their respective cellular components. Cancer-associated fibroblasts (CAFs), a major part the cells, are key determinant in progression, while glucose-regulated protein (GRP)78 overexpressed many human cancers involved invasion metastasis. This study developed microfluidic-based three dimension (3D) co-culture device to mimic an vitro order investigate cell real-time. bionic chip provided significant information...
Abstract Memristors, demonstrated by solid‐state devices with continuously tunable resistance, have emerged as a new paradigm for self‐adaptive networks that require synapse‐like functions (artificial synapse, example). Spin‐based memristors offer advantages over other types of because their significant endurance and high energy efficiency. Yet it remains challenge to build dense functional spintronic structures materials are compatible existing ferromagnetic devices. Here, memristive device...
Invadopodia or invasive feet, which are actin-rich membrane protrusions with matrix degradation activity formed by cancer cells, a key determinant in the malignant progression of tumors and represent an important target for therapies. In this work, we presented microfluidic 3D culture device continuous supplement fresh media via syringe pump. The mimicked tumor microenvironment vivo could be used to assay invadopodia formation study mechanism human lung invasion. With device, investigated...
A novel voltage-controlled skyrmion memristor (VCSK-Memristor) based on a multiferroic heterostructure is proposed and studied. Under electric-field-modulated magnetic anisotropy via remnant strain, continuously tunable resistance obtained in VCSK-Memristor due to the size modulation ferromagnetic layer. Geometrical scaling studies are performed provide guidelines for design optimization of this newly spintronic device. The results indicate that advantageous fabricating energy-efficient...
To effectively diagnose open-circuit (OC) faults in the insulated gate bipolar transistor (IGBT) of a cascaded H-bridge rectifier (CHBR) real-time, this paper uses single-phase three-cell CHBR as an example. Through mechanism analysis, variation patterns capacitor voltage and grid current due to OC are defined. Based on this, DC threshold (VT) coefficient (CCV) introduced fault diagnosis indices, real-time method for is established. The robustness, accuracy, timeliness, universality proposed...
Information security is of great importance for the approaching Internet things (IoT) era. Physically unclonable functions (PUFs) have been intensively studied information security. However, silicon PUFs are vulnerable to hazards such as modeling and side-channel attacks. Here we demonstrate a magnetic analogue PUF based on perpendicularly magnetized Ta/CoFeB/MgO heterostructures. The perpendicular anisotropy originates from CoFeB/MgO interface, which sensitive subnanometer variation MgO...
Bacterial cancer targeting may become an efficacious therapy, but the mechanisms underlying bacterial specificity for cells need to be explored prior adopting it as a new clinical application. To characterize mechanism of chemotactic preference towards cells, we developed microfluidic device in vitro study. The consists cell culture chamber on both sides central bacteria channel, with micro-channels used barriers between them. device, when model lung cancer, was able provide simultaneous...
In this study, a memristor driven by spin–orbit torque (SOT) is realized in the nanoscale thickness L10 FePt systems with high perpendicular magnetization anisotropy (PMA). Due to domain nucleation and expansion current pulses, multilevel Hall resistance states can be continuously tuned density, where memristive are retained wall pinning effects. The properties of for samples different structures associated magnitude field-like torque, larger efficiency enhances multiple characteristics....
Abstract Detection of vector magnetic fields at nanoscale dimensions is critical in applications ranging from basic material science and fundamental physics to information storage medical diagnostics. So far, field sensing achieved solely by exploiting a single nitrogen‐vacancy (NV) center diamond, evaluating the Zeeman splitting NV spin qubits using technique an optically‐detected resonance. This protocol requires complex optical setup expensive detection systems detect photoluminescence...
Three-dimensional (3D) vector magnetic sensors play a significant role in variety of industries, especially the automotive industry, which enables control precise position, angle, and rotation motion elements. Traditional 3D integrate multiple with their sensing orientations along three coordinate axes, leading to large size inevitable nonorthogonal misalignment. Here, we demonstrate wide linearity range sensor utilizing single
// Encheng Li 1,* , Zhiyun Xu Hui Zhao 2,* Sun 1 Lei Wang 3 Zhe Guo Yang Zhancheng Gao 4 and Qi Department of Respiratory Medicine, The Second Affiliated Hospital, Dalian Medical University, Dalian, China 2 Physical Examination Center, Liaoning Provincial Key Laboratory for Micro/Nano Technology, University & Critical Care People's Hospital Peking Beijing, * These authors contributed equally to this work Correspondence to: Wang, email: Gao, Keywords : Macrophages, malignant transformation,...
The spin torque effects discovered in spintronics have a broad prospect for applications information memory and logic devices, wherein deterministic switching is highly desired. Variations between devices originating from the fabrication process inherently random physical features are detrimental to devices; however, they potential entropy sources hardware security primitives. Here, we demonstrate two types of spin–orbit (SOT)-based reconfigurable physically unclonable functions (rPUFs) that...
Fibroblasts, the major cell type in tumor stroma, are essential for growth and survival, represent an important therapeutic target cancers. Here we presented a microfluidic co-culture device which three-dimensional (3D) matrix was employed to reconstruct vivo-like fibroblast-tumor microenvironment investigation of role myofibroblasts induced by lung cancer cells chemoresistance VP-16. Composed double-layer chip injection pump, houses fibroblasts co-cultured 3D 2D mode induce become with...
Analog arithmetic operations are the most fundamental mathematical used in image and signal processing as well artificial intelligence (AI). In-memory computing (IMC) offers a high performance energy-efficient paradigm. To date, in-memory analog with emerging nonvolatile devices usually implemented using discrete components, which limits scalability blocks large scale integration. Here, prototypical implementation of (summation, subtraction multiplication) is experimentally demonstrated,...
In this study, current-induced partial magnetization-based switching was realized through the spin–orbit torque (SOT) in single-layer L10 FePt with a perpendicular anisotropy (Ku⊥) of 1.19 × 107 erg·cm−3 (1 = 0.1 J·m−3), and its corresponding SOT efficiency (βDL) 8 10−6 Oe·(A·cm−2)−1 Oe 79.57747 A·m−1), which is several times higher than that traditional Ta/CoFeB/MgO structure reported past work. The films originated from structural inversion asymmetry since dislocations defects were...