A5103262233- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Plant Gene Expression Analysis
- Plant Pathogens and Fungal Diseases
- Neurological Disease Mechanisms and Treatments
- Mycotoxins in Agriculture and Food
- Adipose Tissue and Metabolism
- Flavonoids in Medical Research
- Microbial Inactivation Methods
- Advanced Drug Delivery Systems
- RNA modifications and cancer
- Image Processing and 3D Reconstruction
- Probiotics and Fermented Foods
- Chromosomal and Genetic Variations
- Liver physiology and pathology
- Diet and metabolism studies
- Civil and Geotechnical Engineering Research
- Amino Acid Enzymes and Metabolism
- Asthma and respiratory diseases
- Enzyme Structure and Function
- Ocular Infections and Treatments
- Remote Sensing and Land Use
- 3D Shape Modeling and Analysis
- Evaluation Methods in Various Fields
- Plant Stress Responses and Tolerance
Nanchang University
2024
University of Science and Technology Beijing
2024
Shenyang Pharmaceutical University
2024
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
Nanjing University of Chinese Medicine
2023-2024
Jiangsu Province Hospital
2024
Fudan University
2023
Sichuan Agricultural University
2017-2023
Rice Research Institute
2017-2023
Broad-spectrum resistance is highly preferred in crop breeding programmes. Previously, we have reported the identification of broad-spectrum resistance-Digu 1 (bsr-d1) allele from rice Digu. The bsr-d1 prevents activation Bsr-d1 expression by Magnaporthe oryzae infection and degradation H2 O2 peroxidases, leading to M. oryzae. However, it remains unknown whether defence pathways other than burst peroxidases contribute bsr-d1-mediated immunity. Blast was determined leaves spray punch...
Tumor stroma and growth factors provide a survival environment to tumor cells can modulate their chemoresistance by dysregulating several signal pathways. In this study, we fabricated three-dimensional (3D) microfluidic chip using polydimethylsiloxane (PDMS) investigate the impact of hepatocyte factor (HGF) from cancer-associated fibroblasts (CAF) on Met/PI3K/AKT activation, glucose regulatory protein (GRP78) expression paclitaxel-induced A549 cell apoptosis. With concentration gradient...
bsr-d1, an allele encoding a transcription factor identified from the rice cultivar Digu, confers durable, broad-spectrum resistance to infections by strains of Magnaporthe oryzae. bsr-d1 was predicted inhibit M. oryzae-induced expression Bsr-d1 RNA and degradation hydrogen peroxide achieve However, global effect biological process molecular function on blast mediated remains unknown. In this study, we compared transcriptomic profiling between knockout (Bsr-d1KO) lines wild type, TP309. Our...
Fungal pathogens typically use secreted effector proteins to suppress host immune activators facilitate invasion. However, there is rarely evidence supporting the idea that fungal secretory contribute pathogenesis by transactivating genes defense. We previously found pathogen Magnaporthe oryzae induces rice Bsr-d1 infection and hypothesized a mediates this induction. Here, we report MoSPAB1 M. directly binds promoter induce its expression, facilitating pathogenesis. Amino acids 103-123 of...
Maize, one of the world's major food crops, is facing challenge rising temperature. Leaf senescence most significant phenotypic change maize under heat stress at seedling stage, but underlying molecular mechanism still unknown. Here, we screened for three inbred lines (PH4CV, B73, and SH19B) that showed differentially senescing phenotypes stress. Among them, PH4CV no obviously phenotype stress, while SH19B demonstrated a severely phenotype, with B73 being between two extremes. Subsequently,...
Rhein, a component derived from rhubarb, has been proven to possess anti-inflammatory properties. Here, we show that rhein mitigates obesity by promoting adipose tissue thermogenesis in diet-induced obese mice. We construct macrophage-adipocyte co-culture system and demonstrate promotes adipocyte through inhibiting NLRP3 inflammasome activation macrophages. Moreover, clues acetylome analysis identify SIRT2 as potential drug target of rhein. further verify directly interacts with inhibits...
Abstract Background: Previous clinical studies reported low molecular weight heparin (LMWH) monotherpay has been utilized for the treatment of recurrent abortion (RCA) with antiphospholipid system (APS). However, its efficacy is still inconclusive. This systematic review aims to assess and safety patients RCA APS. Methods: A literature search article up February 2019 will be conducted in 9 databases: Cochrane Library, EMBASE, MEDILINE, Cumulative Index Nursing Allied Health Literature,...
Introduction & Objective: Rhein, a component derived from rhubarb as well the active metabolite of anti-osteoarthritis drug diacerein, has been proven to possess strong anti-inflammatory properties. However, exact mechanism underlying effects rhein, and role rhein in ameliorating obesity remains unclear. Methods: Diet induced obese (DIO) mice were employed observe on metabolism. A macrophage-adipocyte co-culture system was constructed elucidate beneficial effect Acetylome analysis...
The cultivated Zizania latifolia, an aquatic vegetable prevalent in the Yangtze River Basin, represents a unique plant-fungus complex whose domestication is associated with host-parasite co-evolution. In this study, we present high-quality, chromosome-scale genome assembly of Z. latifolia. We employed PacBio long-read sequencing and Hi-C technology to generate ~578.42 Mb assembly, which contains 47.59% repeat sequences contig N50 ~33.75 Mb. contigs were successfully clustered into 17...
Rhein, which is one of the main active components Rheum palmatum, has a range pharmacological activities such as regulation metabolism glucose and lipids, anti-inflammatory, anti-tumor, anti-fibrosis, etc. Epigenetics refers to heritable variation gene expression without altering DNA sequence. It involved in emergence development inflammation, renal fibrosis, diabetes, cancer, atherosclerosis, other diseases, thus becoming new strategy for treatment many di-seases. A series studies have...
Refractory asthma is an inevitable clinical difficulty that often faced by pediatricians in the promotion of standardized diagnosis and treatment asthma.In this paper, important role multidimensional assessment (MDA) refractory emphasized, method MDA described detail at first.Then foreign domestic research on internal mechanism truly recent years syste-matically reviewed, which shows progress phenotypes, biomarkers targeted to readers, with a view developing pediatricians′ ideas further...