A5019379377- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Microtubule and mitosis dynamics
- Extracellular vesicles in disease
- RNA modifications and cancer
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Biomarkers in Disease Mechanisms
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Histone Deacetylase Inhibitors Research
Affiliated Hospital of Nantong University
2015-2024
Nantong University
2015-2024
Zhongshan Hospital
2019-2021
Fudan University
2019-2021
Overexpression of Flap endonuclease 1 (FEN1) has been previously implicated in hepatocellular carcinoma (HCC), while its expression features and mechanisms remain unclear.In the current study, differential genes (DEGs) were screened HCC tissues normal liver 4 Gene Expression Omnibus (GEO) datasets.FEN1, one hub co-overexpressed genes, was further determined overexpressed TCGA, local cohorts, hepatocarcinogenesis model.In addition, high FEN1 indicated poor prognosis patients.Loss-of-function...
Purpose: N6-methyladenosine (m 6 A) RNA methylation has been implicated in various malignancies. This study aimed to identify the m A regulator-based prognostic signature for hepatocellular carcinoma (HCC) as well provide candidate targets HCC treatment. Methods: The least absolute shrinkage and selection operator (LASSO) analyses were performed a risk Cancer Genome Atlas (TCGA) datasets. was further validated International Consortium (ICGC) Pan-Cancer Analysis of Whole Genomes (PCAWG)...
Abstract Background DNA primase subunit 1 (PRIM1) has been reported as a novel oncogene in several cancer types. However, its roles hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate underlying mechanisms of PRIM1 and identify it potential molecular target for HCC. Methods Hub genes were screened between HCC tissues normal liver 3 gene expression omnibus (GEO) datasets the genome atlas (TCGA). The features prognostic value one hub analyzed by bioinformatic...
S100A11, a member of S100 calcium-binding protein family, is associated with the numerous processes tumorigenesis and metastasis. In present study, role its possible underlying mechanisms in cell proliferation, apoptosis cycle distribution human pancreatic cancer were explored. Immunohistochemical analyses S100A11 phosphorylated (p)-AKT serine/threonine kinase (AKT) performed 30 resected specimens from patients cancer. PANC-1 cells transfected pcDNA3.1-S100A11 or treated 50 µmol/l LY294002...
Abstract Aberrant de novo lipogenesis (DNL) results in excessive hepatic lipid accumulation and liver steatosis, the causative factors of many diseases, such as non-alcoholic fatty disease (NAFLD), steatohepatitis (NASH), hepatocellular carcinoma (HCC). However, underlying mechanism DNL dysregulation remains largely unknown. Ubiquitination proteins hepatocytes has been shown to be widely involved metabolism liver. Here, we revealed that Ubiquitin-specific peptidase 7 (USP7), a deubiquitinase...
Ubiquitin-specific protease 7 (USP7) is a de-ubiquitin enzyme that plays an essential role in multiple cancers and becomes target for treatment. However, the of USP7 its therapeutic value HCC remains unclear.USP7 expression was examined tissues by western blot immunohistochemistry. The correlation prognosis analyzed Kaplan-Meier survival method. Mass spectrometry determined cell proliferation tumorigenicity assays were conducted vitro vivo treated P22077 sgRNA-USP7.USP7 significantly...
Golgi protein 73 (GP73) is a resident type II transmembrane that has been reported to markedly increase in chronic liver disease, particularly hepatocellular carcinoma (HCC). However, it remains unclear as whether serum GP73 represents reliable marker for the diagnosis of HCC. The aim present study was evaluate diagnostic value patients with HCC and determine accuracy measuring combination α‑fetoprotein (AFP) γ‑glutamyl transferase isoenzyme (GGT‑Ⅱ) Serum detected using time‑resolved...
Abstract β-Adrenergic receptor (β-AR) signalling is strongly associated with tumour progression by the coupling of β-ARs either a G protein or β-arrestin; however, related mechanism underlying hepatocellular carcinoma (HCC) metastasis not clear. Here, we reveal that transcription factor Y-box binding 1 (YB-1) interacts β2-adrenergic (β2-AR) following stimulation agonist isoproterenol (ISO). Clinicopathological analysis demonstrated β2-AR significantly correlated YB-1, which favours HCC. The...
Abstract C‐terminal binding protein‐2 (CtBP2), as a transcriptional co‐repressor, has been shown to mediate the repression of p16 INK4A , tumor suppressor gene product, in primary human cells. Here we aimed investigate how correlation between CtBP2 and influenced development esophageal squamous cell carcinoma (ESCC). Immunohistochemistry ESCC tissue sections indicated that expressions were inversely correlated each other with linear regression coefficient −0.747 ( P < 0.05), Western blot...
Bcl-2-associated athanogene-1 (BAG-1) is a multifunctional anti-apoptotic protein which regulates an array of cellular processes, including apoptosis, signaling, proliferation, transcription, and cell motility has been reported to be over-expressed in number human malignancies. To investigate the possible involvement BAG-1 tumorigenesis hepatocellular carcinoma (HCC), we performed Western blot analysis eight paired samples HCC adjacent peritumoral tissues immunohistochemistry 65 paraffin...
Inflammatory diseases are often initiated by the activation of inflammasomes triggered pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated (DAMPs), which mediate pyroptosis. Although pyroptosis resulting from aberrant inflammasome triggering in thyroid follicular cells (TFCs) has been observed Hashimoto's thyroiditis (HT) patients, underlying mechanisms remain largely unknown. Given extensive involvement protein ubiquitination deubiquitination inflammatory...