A5018063099- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- RNA Research and Splicing
- Computational Drug Discovery Methods
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Energy, Environment, Economic Growth
- Conducting polymers and applications
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Perovskite Materials and Applications
- Cancer-related Molecular Pathways
- Protein Structure and Dynamics
- Inflammatory Biomarkers in Disease Prognosis
- Energy, Environment, and Transportation Policies
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Photocatalysis Techniques
- Microtubule and mitosis dynamics
- Atherosclerosis and Cardiovascular Diseases
- Environmental Impact and Sustainability
- Protease and Inhibitor Mechanisms
- Climate Change Policy and Economics
- Quantum Dots Synthesis And Properties
Xinjiang University of Finance and Economics
2024-2025
Nanjing Medical University
2023-2025
Changshu No.1 People's Hospital
2020-2024
Zhejiang Sci-Tech University
2022
Shantou University
2021-2022
Shantou University Medical College
2021-2022
Changsha University
2022
Harbin Medical University
2019
Affiliated Hospital of Nantong University
2016
Nantong University
2015-2016
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects several organs and causes variable clinical symptoms. Exploring new insights on genetic factors may help reveal SLE etiology improve the survival of patients. The current study designed to identify key genes involved in develop potential diagnostic biomarkers for practice. Expression data all control samples GSE65391 GSE72509 datasets were downloaded from Gene Omnibus (GEO) database. A total 11 accurate...
Background: The present study aimed to investigate the relationship between prognostic nutritional index (PNI) and peripheral blood neutrophil lymphocyte ratio (NLR), prognosis of patients with advanced non-small cell lung cancer (NSCLC) treated platinum-based therapeutics.
Carbon reduction is imperative for achieving carbon peaking and neutrality. Accordingly, it important to determine which industrial sectors have more responsibility in this matter. Based on data from Zhejiang's input-output tables, study applies the Input-Output method measure compare emissions of 42 Zhejiang Province 2002 2017, then assesses emission attributes each sector, ultimately determines perspectives producers consumers. The results show that direct whole-process increased...
Consumer responsibility is an important theoretical perspective for realizing China's "carbon neutrality" policy goals. A model was developed based on the value-belief-norm and theory of planned behavior to estimate urban residents' willingness pay (WTP) carbon neutrality. Based contingent valuation method, a single-bounded dichotomous choice elicitation format used in questionnaire survey, 2,040 samples family households Zhejiang Province were randomly sampled. Subsequently, binary logistic...
Predicting drug-target binding affinity (DTA) is a crucial task in drug discovery research. Recent studies have demonstrated that pocket features and interactions between targets drugs significantly improve the understanding of DTA. However, challenges remain, particularly detailed consideration both global local information further modeling features. In this paper, we propose novel multimodal deep learning model named MMPD-DTA for predicting to address these challenges. The integrates graph...
PFTK1, also known as PFTAIRE1, CDK14, is a novel member of Cdc2-related serine/threonine protein kinases. Recent studies show that PFTK1 highly expressed in several malignant tumors such hepatocellular carcinoma, esophageal cancer, breast and involved regulation cell cycle, proliferation, migration, invasion further influence the prognosis tumors. However, expression physiological significance gastric cancer remain unclear. In this study, we analyzed clinical by Western blot 8 paired fresh...
Abstract Rare variants contribute significantly to the genetic causes of complex traits, as they can have much larger effects than common and account for missing heritability in genome-wide association studies. The emergence UK Biobank scale datasets accurate gene-level rare variant–trait testing methods dramatically increased number variant associations that been detected. However, no systematic collection these has carried out date, especially at gene level. To address issue, we present...
Non-small cell lung cancer (NSCLC) is the major cause of cancer-related lethality among human patients globally, and poor prognosis this mainly explained by metastasis, so it essential to find out molecule mechanisms a novel therapeutic for NSCLC. A disintegrin metalloprotease with thrombospondin motif 5 (ADAMTS5) belongs protease family. It has been reported participate in tumor migration invasion. In study, we showed that expression ADAMTS5 was higher tissues Western blot. The...
Individualized drug response prediction is vital for achieving personalized treatment of cancer and moving precision medicine forward. Large-scale multi-omics profiles provide unprecedented opportunities therapy. In this study, we propose a pipeline to identify subpathway signatures anticancer individuals by integrating the comprehensive contributions multiple genetic epigenetic (gene expression, copy number variation DNA methylation) alterations. Totally, 46 associated with individual...
Drug repurposing identifies new clinical indications for existing drugs. It can be used to overcome common problems associated with cancers, such as heterogeneity and resistance established therapies, by rapidly adapting known drugs treatment. In this study, we utilized a recommendation system learning model prioritize candidate cancer We designed drug-drug pathway functional similarity integrating multiple genetic epigenetic alterations gene expression, copy number variation (CNV), DNA...
The interactions among non-coding RNA (ncRNA) and binding protein (RBP) are increasingly recognized as one of basic mechanisms in gene regulation, play a crucial role cancer progressions. However, the current understanding this regulation network, especially its dynamic spectrum according to differentially expressed nodes (i.e. ncRNAs RBP) is limited. Utilizing transcriptomics interactomics resources, dysregulated RBP-ncRNA circuits (RNCs) systematically dissected across 14 tumor types. We...
Gene expression plays a pivotal role in various diseases, contributing significantly to their mechanisms. Most GWAS risk loci are non-coding regions, potentially affecting disease by altering gene specific tissues. This is notably tissue-specific, with genetic variants substantially influencing it. However, accurately detecting the Quantitative Trait Loci (eQTL) challenging due limited heritability expression, extensive linkage disequilibrium (LD), and multiple causal variants. The single...
Abstract Consumer responsibility is an important theoretical perspective for realizing China’s “carbon neutrality” policy goals. A model was developed based on the value-belief-norm and theory of planned behavior to estimate urban residents’ willingness pay (WTP) carbon neutrality. Based contingent valuation method, a single-bounded dichotomous choice elicitation format used in questionnaire survey, 2,040 samples family households Zhejiang Province were randomly sampled. Subsequently, binary...
Predicting protein-ligand binding affinity is essential for understanding interactions and advancing drug discovery. Recent research has demonstrated the advantages of sequence-based models graph-based models. In this study, we present a novel hybrid multimodal approach, DeepTGIN, which integrates transformers graph isomorphism networks to predict affinity. DeepTGIN designed learn sequence features efficiently. The model comprises three modules: data representation module, encoder prediction...
SnO 2 nanoparticles (NPs) have been widely employed as electron transport layers (ETLs) in planar n-i-p perovskite solar cells (PSCs). Perfect ETL/perovskite interface plays a key role high efficiency PSCs, however, the main issues caused by self-aggregation of NPs and recombination limit further improvement device performance. Here, L-carnitine hydrochloride (L-ch) zwitterion with multiple functional groups has incorporated into NP solution for high-efficiency PSCs. The results demonstrate...
Abstract Objective: The purpose of this study was to investigate the relationship between neutrophil-lymphocyte ratio (NLR), platelet distribution width (PDW) and prognostic nutrient index (PNI), prognosis patients with advanced non-small-cell lung cancer (NSCLC) treated platinum-based chemotherapy.Methods: A total 428 NSCLC chemotherapy January 2015 June 2019 were retrospectively analyzed. randomly divided into training set (n=300) test (n=128) in a 7:3, respectively. Clinical data...