A5102004674- Microbial Inactivation Methods
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Toxin Mechanisms and Immunotoxins
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Health, Environment, Cognitive Aging
- Natural Antidiabetic Agents Studies
- Microtubule and mitosis dynamics
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Genomics and Rare Diseases
- Genomics, phytochemicals, and oxidative stress
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Ocular and Laser Science Research
- Dietary Effects on Health
Sun Yat-sen University
2025
Renji Hospital
2023-2024
Shanghai Jiao Tong University
2019-2024
Wellcome Sanger Institute
2024
Southern Medical University
2013-2024
Zhejiang Chinese Medical University
2024
Affiliated Hospital of Nantong University
2015-2024
Nantong University
2015-2024
The First People's Hospital of Shunde
2018-2024
TCM-Intigrated Cancer Center of Southern Medical University
2024
Abstract Accurately predicting and selecting patients who can benefit from targeted or immunotherapy is crucial for precision therapy. Trophoblast cell surface antigen 2 (Trop2) has been extensively investigated as a pan-cancer biomarker expressed in various tumours plays role tumorigenesis through multiple signalling pathways. Our laboratory successfully developed two 68 Ga-labelled nanobody tracers that rapidly specifically target Trop2. Of the tracers, [ Ga]Ga-NOTA-T4, demonstrated...
Background Increasing infiltration of CD8 + T cells within tumor tissue predicts a better prognosis and is essential for response to checkpoint blocking therapy. Furthermore, current clinical protocols use unfractioned cell populations as the starting point transduction chimeric antigen receptors (CARs)-modified cells, but optimal subtype CAR-modified remains unclear. Thus, accurately identifying group cytotoxic lymphocytes with high antitumor efficacy imperative. Inspired by theory yin...
ARID1A is a key mammalian SWI/SNF complex subunit that mutated in 5% to 11% of lung cancers. Although recent studies have elucidated the mechanism underlying dysregulation switch/sucrose non-fermentable (SWI/SNF) complexes cancers, significance loss and its implications cancers remain poorly defined. This study investigates how affects initiation progression cancer. In genetically engineered mouse models bearing mutant Kras deficient Trp53 allele (KP), (KPA) promoted tumorigenesis. Analysis...
Abstract The response rate of pancreatic cancer to chemotherapy or immunotherapy is low. Although minimally invasive irreversible electroporation (IRE) ablation a promising option for irresectable cancers, the immunosuppressive tumour microenvironment that characterizes this type enables recurrence. Thus, strengthening endogenous adaptive antitumour immunity critical improving outcome therapy and post-ablation immune therapy. Here we present hydrogel microsphere vaccine amplifies anti-cancer...
To analyze the treatment modalities and trends for neovascular glaucoma (NVG) over past 10 years, we conducted a retrospective analysis at Zhongshan Ophthalmic Center on 1331 NVG inpatients who received 1459 treatments 1383 eyes between January 1, 2012, December 31, 2021. Over time, observed progressive annual increase in both number of patients volume surgeries NVG, with an percentage change (APC) 10.23% (95% confidence interval [CI]: 5.5-15.2%, P = 0.001) 11.59% CI: 6.6-16.9%, 0.001),...
Heat stroke (HS) is a severe condition characterized by increased morbidity and high mortality. Acute liver injury (ALI) well-documented complication of HS. The tumor suppressor p53 plays an important role in regulation mitochondrial integrity mitophagy several forms ALI. However, the p53-regulated HS-ALI remains unclear. In our study, we discovered dynamic changes hepatocytes demonstrated protective effects activation on HS-ALI. Pretreatment with 3-MA or Mdivi-1 significantly exacerbated...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable malignancies to overcome clinically due its insidious onset as well rapid progression. It urgent seek new diagnostic markers and therapeutic targets in order furthest ameliorate prognosis patients with PDAC. V-set immunoglobulin domain containing 2 (VSIG2) belongs superfamily (IgSF), which function coinhibitory molecule mediate immune evasion tumors. Nevertheless, role VSIG2 PDAC related mechanism...
Abstract Background This study intends to investigate the immunological effects of tumor ablation with irreversible electroporation (IRE). Methods We evaluated systemic immune response in patients hepatocellular carcinoma (HCC) after IRE treatment. Furthermore, we analyzed infiltrating T lymphocytes and level serum cytokines control groups tumor-bearing mice. Results observed that induced an increase WBC, neutrophil monocyte counts a decrease lymphocyte count 1 day post-IRE returned baseline...
Capability of tumor cells to impede immune response are largely associated with their interaction and regulation CD4+CD25+ forkhead box transcription factor (Foxp)3+ regulatory T (Treg) cells, which suppress cytotoxic cell-mediated immunity in the microenvironment. Foxp3 level is critical for development phenotypic maintenance Treg, regulated by transcriptional control epigenetic modification. Here, we showed that higher percentage intratumoral Treg was positively correlated lower promoter...
Previous studies have shown that PRDX1 is upregulated in some types of malignant tumors. The role non-small-cancer lung carcinoma (NSCLC) remains unclear. This study aims to identify the influencing in-vitro biological functions NSCLC and molecular mechanism.We collected 50 cases fresh adjacent non-tumoral tissues for detecting differential expressions by quantitative real-time polymerase chain reaction (qRT-PCR). Survival time patients, defined as period from operation latest follow-up or...
The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. aim the present study was to explore intrinsic brain functional activity alterations in ETTH.Resting-state magnetic resonance imaging (rs-fMRI) data were collected from 32 patients with ETTH and age- gender-matched healthy controls (HCs). Differences between HCs analyzed utilizing fractional amplitude low-frequency fluctuation (fALFF) approach. Correlation analyses performed examine relationship fALFF...
Abstract Objectives To explore the efficacy and safety of Transarterial chemoembolization (TACE) in combination with immune checkpoint inhibitors (ICIs) tyrosine kinase (TKIs) patients unresectable hepatocellular carcinoma (uHCC). Methods 456 HCC receiving either TACE ICIs TKIs (combination group, n = 139) or monotherapy (monotherapy 317) were included from Apr 2016 to Dec 2021 this retrospective study. We employed propensity score matching (PSM), performed 1:2 optimal pair matching, balance...
<ns3:p>Birth cohort studies involve repeated surveys of large numbers individuals from birth and throughout their lives. They collect information useful for a wide range life course research domains, biological samples which can be used to derive data an increasing collection omic technologies. This rich source longitudinal data, when combined with genomic offers the scientific community valuable insights ranging population genetics applications across social sciences. Here we present...
To evaluate the utility of trio-based prenatal exome sequencing (pES), incorporating splice-site and mitochondrial genome assessment, in diagnosis fetuses with ultrasound anomalies normal copy-number variant (CNV-seq) results.This was a prospective study 90 ongoing pregnancies that underwent pES after receiving CNV-seq results, from September 2020 to November 2021, single center China. By using panel encompassing coding splicing regions as well for parents, we identified underlying genetic...
Objective . The purpose of the present study is to explore correlation between nuclear expression cyclin-dependent kinase inhibitor 1B (p27) and clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient survival. Methods Immunohistochemistry was used examine p27 130 primary NPC tissues. relationship levels characteristics analyzed. Survival curves were plotted using Kaplan-Meier method compared log-rank test. significance various survival variables analyzed multivariate...
Background: Tumors at the hepatocaval confluence are difficult to treat, either surgically or ablatively. Methods: A retrospective longitudinal study on patients ineligible for thermal ablation who underwent computed tomography-guided IRE hepatic tumors was conducted. Factors analyzed included patient and tumor characteristics, procedure details, treatment-related complications, prognosis. Results: Between 2017 2021, 21 our institute received percutaneous IRE. Of 38 lesions, were confluence....
Hepatocellular carcinoma (HCC) is an aggressive form of liver cancer with particularly poor survival rates for patients. Targeted molecular therapies are lacking, and current treatment generally limited to surgical resection or transplantation. Overexpression aberrant signaling the ErbB family receptors has been implicated in HCC, but mechanisms underlying overexpression unclear. In this study, we investigated potential role neuregulin receptor degradation protein-1 (Nrdp1), a regulator...
Abstract Pancreatic ductal adenocarcinoma (PDAC), a deadly cancer characterized by multiple molecular alterations, remains the most lethal cancer, with 5‐year survival rate of about 3–15%. Early diagnosis and treatment monitoring are essential to improve patient survival. Traditional imaging methods can only provide structural information, but not biological processes. Nuclear medicine combines high sensitivity radionuclides high‐resolution visualize specific targets PDAC for more accurate...
As a highly aggressive cancer, hepatocellular carcinoma (HCC) is often found at an advanced stage and has poor prognosis. Therefore, in addition to the surgical treatment of HCC, drug therapy for HCC still under continuous exploration. The primary apolipoprotein high-density lipoproteins (HDLs) A-I binding protein (AIBP), which significant impact on cholesterol metabolism, angiogenesis, wide range inflammatory disorders, including cancer. AIBP function is, however, yet unknown. This study...