A5101859868- Chromatin Remodeling and Cancer
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Mechanisms of cancer metastasis
- Computational Drug Discovery Methods
- Nanoplatforms for cancer theranostics
- Catalytic Processes in Materials Science
- Protein Degradation and Inhibitors
- Nerve injury and regeneration
- Electrocatalysts for Energy Conversion
- Ubiquitin and proteasome pathways
- Hepatitis C virus research
- Virus-based gene therapy research
- Technology and Security Systems
- Dye analysis and toxicity
- Electrochemical sensors and biosensors
- Thermal and Kinetic Analysis
- Dendrimers and Hyperbranched Polymers
- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Radiation Detection and Scintillator Technologies
- Genomics, phytochemicals, and oxidative stress
- Animal Virus Infections Studies
- Lung Cancer Diagnosis and Treatment
Bengbu Medical College
2021-2024
First Affiliated Hospital of Bengbu Medical College
2022-2023
Yuncheng University
2022
Jiangxi Agricultural University
2019
Institute of Plant Protection
2011
China Institute Of Communications
2007
Samsung (China)
2007
ARID1A is a key mammalian SWI/SNF complex subunit that mutated in 5% to 11% of lung cancers. Although recent studies have elucidated the mechanism underlying dysregulation switch/sucrose non-fermentable (SWI/SNF) complexes cancers, significance loss and its implications cancers remain poorly defined. This study investigates how affects initiation progression cancer. In genetically engineered mouse models bearing mutant Kras deficient Trp53 allele (KP), (KPA) promoted tumorigenesis. Analysis...
Sensitive and rapid detection of pesticides in food has become an important crucial research area due to the extensive use agriculture residues stringent environmental protection acts. In present work, electrochemical nanohybrid sensor was facilely developed based on carboxymethyl cellulose (CMC) fuctionalized carbon nanotubes (CNTs). The shows high sensitivity, excellent stability good anti-interference capability carbendazim (MBC) by differential pulse voltammetry method. Under optimized...
Abstract Conversion of astrocytes into neurons in vivo offers an alternative therapeutic approach for neuronal loss after injury or disease. However, not only the efficiency conversion functional by single Neurog2, but also conundrum that whether Neurog2-induced cells (Neurog2-iNs) are further functionally integrated existing matured neural circuits remains unknown. Here, we adopted AAV(2/8) delivery system to overexpress factor Neurog2 and found majority were successfully converted multiple...
Lung cancer is the leading cause of cancer-related deaths worldwide, synthesizing and screening novel anti-cancer drugs provides an alternative therapeutic strategy for renewal chemotherapy regimens against lung cancer. To this end, several compounds were synthesized based on modification original myricetin, their anti-tumor activity human non-small cell (NSCLC) A549 cells measured. Among myricetin derivatives, S4-10 has displayed highest antitumor efficacy in dose-dependent manner. The...
Abstract Background To investigate the effects of computed tomography (CT) reconstruction slice thickness and contrast‐enhancement phase on differential diagnosis performance radiomic signature in lung adenocarcinoma. Methods A total 187 patients who had been pathologically confirmed with adenocarcinoma nonadenocarcinoma were divided into a training cohort ( n = 149) validation 38). All underwent contrast‐enhanced CT images reconstructed different thickness. The features extracted from scan...
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in catastrophic damage worldwide. Accordingly, the development of powerful, safe, easily accessible vaccines with long-term effectiveness is understood as an urgently needed countermeasure against this ongoing pandemic. Guided strong promise using AAVs, we here designed, optimized, and developed AAV-based (including AAV-RBD(max), AAV-RBD(wt), AAV-2xRBD,...
The combination of radiotherapy and chemotherapy is a common useful treatment mode for tumours. But traditional methods inevitably lead to variety side effects. A drug delivery system (DDS), which has good biocompatibility strong anti-tumour ability, expected solve this problem. Studies have shown that Ce-based nanoparticles (NPs) radiosensitization effect through the photoelectric effect. Hence, cisplatin-loaded LiLuF 4 :Ce 3+ scintillation NPs (NP + Cis) were first constructed in study,...
<title>Abstract</title> KRAS mutation represents a formidable challenge in cancer treatment. Here, we explored the CasRx-editing approach on lung adenocarcinoma driven by activation and Tp53 loss vivo, scenario closely resembling clinical conditions. We screened seven sgRNAs vitro identified CasRx + sgRNA5 effectively suppressed Kras-G12D transcript levels, leading to attenuation of cell growth. Subsequently, administered via vivo Adeno-associated viruses (AAV) delivery at early...
<div>Abstract<p>ARID1A is a key mammalian SWI/SNF complex subunit that mutated in 5% to 11% of lung cancers. Although recent studies have elucidated the mechanism underlying dysregulation switch/sucrose non-fermentable (SWI/SNF) complexes cancers, significance ARID1A loss and its implications cancers remain poorly defined. This study investigates how affects initiation progression cancer. In genetically engineered mouse models bearing mutant <i>Kras</i> deficient...
Supplementary Data from Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability
<div>Abstract<p>ARID1A is a key mammalian SWI/SNF complex subunit that mutated in 5% to 11% of lung cancers. Although recent studies have elucidated the mechanism underlying dysregulation switch/sucrose non-fermentable (SWI/SNF) complexes cancers, significance ARID1A loss and its implications cancers remain poorly defined. This study investigates how affects initiation progression cancer. In genetically engineered mouse models bearing mutant <i>Kras</i> deficient...
Supplementary Data from Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability