A5100642566- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Ear Surgery and Otitis Media
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Peroxisome Proliferator-Activated Receptors
- Endoplasmic Reticulum Stress and Disease
- Glycosylation and Glycoproteins Research
- Hearing, Cochlea, Tinnitus, Genetics
- Galectins and Cancer Biology
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Folate and B Vitamins Research
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Nasal Surgery and Airway Studies
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Tracheal and airway disorders
- Lung Cancer Research Studies
Peking University
2018-2025
Peking University Cancer Hospital
2018-2025
Central South University
2012-2025
Wenzhou Medical University
2021-2025
First Affiliated Hospital of Wenzhou Medical University
2021-2025
Central South University of Forestry and Technology
2012-2025
Northwest University
2018-2024
Ministry of Education of the People's Republic of China
2017-2024
City University of Hong Kong
2022-2024
Hong Kong Jockey Club
2024
Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation phospholipids, is associated with cellular metabolism, redox homeostasis, and various signaling pathways related to cancer. Aspirin widely used non-steroidal anti-inflammatory drug (NSAID) has been reported show therapeutic benefit in cancers harboring oncogenic PIK3CA, which encodes catalytic p110α subunit phosphoinositide 3-kinase (PI3K). In this study, we found that aspirin sensitized cancer cells...
Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), has been approved for EGFR-mutant non-small-cell lung cancer (NSCLC). We aimed to evaluate the efficacy and safety of neoadjuvant osimertinib in patients with resectable locally advanced NSCLC.This single-arm, phase 2b trial (ChiCTR1800016948) was conducted at six centers mainland China. Patients measurable stage IIA-IIIB (T3-4 N2) adenocarcinoma EGFR exon 19 and/or 21 mutations were...
Advanced colorectal cancer (CRC) is one of the deadliest cancers, and 5-year survival rate patients with metastasis extremely low. The epithelial–mesenchymal transition (EMT) considered essential for metastatic CRC, but fundamental molecular basis underlying this effect remains unknown. Here, we identified that O-GlcNAcylation, a unique posttranslational modification (PTM) involved in metabolic reprogramming, increased capability CRC. levels O-GlcNAcylation were CRC tissues cell lines, which...
Metastasis is the primary cause of death in patients with advanced cancer. Recently, a high-fat diet was shown to specifically promote metastatic potential specific cancer cells CD36-dependent manner. However, molecular basis fatty acid (FA)-induced upregulation CD36 has remained unclear. Methods: RT-qPCR, FACS analysis, immunoblotting and immunohistochemistry, as well retrieving TCGA database, were carried out quantitate expression gastric (GC) tissues cell lines. Transwell assay xenografts...
Abstract Objective Chinese Herb QingBai decoction (QBD) has been approved affective in the treatment of IBD patients clinic. However, underlying mechanism remains unknown. We aim to investigate effect QBD on mouse model ulcerative colitis and its possible mechanism. Methods C57/bL mice were given 5% DSS induce divided as mesalazine group. Weight, faeces mental status recorded each day histopathological changes (goblet cells etc) colon observed after sacrificed. Fluorescein...
Abstract Ferroptosis, a novel regulated cell death induced by iron-dependent lipid peroxidation, plays an important role in tumor development and drug resistance. Long noncoding RNAs (lncRNAs) are associated with various types of cancer. However, the precise roles many lncRNAs tumorigenesis remain elusive. Here we explored transcriptomic profiles primary CRC tissues corresponding paired adjacent non-tumor RNA-seq found that LINC00239 was significantly overexpressed colorectal cancer tissues....
Cystathionine-beta-synthase (CBS) catalyzes the rate-limiting step in transsulfuration pathway for metabolism of homocysteine (Hcy) kidney. Our recent study demonstrates that ischemia-reperfusion reduces activity CBS leading to Hcy accumulation kidney, which turn contributes renal injury. is also capable catalyzing reaction cysteine with produce hydrogen sulfide (H(2)S), a gaseous molecule plays an important role many physiological and pathological processes. The aim present was examine...
Oxidative stress and amplified redox signaling contribute to the pathogenesis of many human diseases including atherosclerosis. The superoxide-generating phagocytic NADPH oxidase is a key source oxidative in developing atheroma. aim present study was examine effect berberine, plant-derived alkaloid, on oxidase-mediated superoxide anion production macrophages. Lipopolysaccharide (LPS) treatment activated THP-1 monocyte-derived macrophages increased intracellular level anions. Preincubation...
An ethyl acetate extract of the roots Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 8-dihydroxy (3) found in plant for first time. Compounds 2 3 are novel compounds. Their antiproliferation activities tested MTT assay four cell lines (breast cancer MCF-7, gastric 7901, melanoma A375 oophoroma SKOV-3).
Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation cis-regulatory elements (CREs) much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case de has been reported to date, in fish without involvement phenotype alteration. Yet, this event likely occurs other animals helps drive genetic/phenotypic variation. Using a porcine model spontaneous hearing loss...
Mounting evidence suggests that long noncoding RNAs (lncRNAs) play important roles in the regulation of gene expression by acting as competing endogenous RNA (ceRNA). However, regulatory mechanisms lncRNA ceRNA gastric cancer (GC) are not fully understood. Here, we first constructed a dysregulated lncRNA-associated network integrating analysis profiles lncRNAs, microRNAs (miRNAs), and messenger (mRNAs). Then, determined three lncRNAs (RP5-1120P11, DLEU2, DDX11-AS1) hub which associated...
Abstract Objective Long non‐coding RNA (lncRNA) has become an important regulator of many human malignancies. However, the biological role and clinical significance most lncRNA in gastric cancer (GC) remain unclear. Methods We investigate function, mechanism action expression MYOSLID GC. First, we analysed differential GC tissues non‐cancerous by analysing sequencing data obtained from The Cancer Genome Atlas. Subsequently, verified that regulates proliferation apoptosis cells acting as a...
Gastric cancer (GC) is a considerable global health burden. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are aberrantly expressed in many cancers and play important roles GC. However, only few lncRNAs have been functionally characterized. In this study, we identified intergenic non-protein coding RNA 941 (LINC00941) potential biomarker for diagnosis prognosis from the genome atlas (TCGA), found expression of LINC00941 associated with tumor depth distant metastasis...
It is universally accepted that aberrant metabolism facilitates tumor growth. However, how cancer cells coordinate glucose and proliferation largely unknown. Sine oculis homeobox homolog 1 (SIX1) a transcription factor belongs to the SIX family believed play an important role in regulation of Warburg effect tumors. whether SIX1 molecular mechanisms regulate its activity are similar hepatocellular carcinoma (HCC) still needs further investigation. Methods: Western blotting was performed...
Lung cancer, ranking second globally in both incidence and high mortality among common malignant tumors, presents a significant challenge with frequent occurrences of drug resistance despite the continuous emergence novel therapeutic agents. This exacerbates disease progression, tumor recurrence, ultimately leads to poor prognosis. Beyond acquired due genetic mutations, mounting evidence suggests critical role epigenetic mechanisms this process. Numerous studies have indicated abnormal...
Diets high in saturated fat and cholesterol facilitate weight gain, a predisposing factor that contributes to the onset of obesity metabolic disorders. Hepatic oxidative stress is commonly reported various animal models has been associated with enhanced expression NADPH oxidase. We have previously several antioxidant mechanisms through which folic acid confers protection during hyperhomocysteinemia-induced stress. The objective present study was investigate whether supplementation...
Nonalcoholic fatty liver disease (NAFLD) is due to the excessive lipid accumulation within hepatocytes. Metabolic nuclear receptors (MNRs) play great roles in homeostasis. We have identified a novel long noncoding RNA (lncRNA), lnc-HC, which regulates hepatocytic cholesterol metabolism through reducing Cyp7a1 and Abca1 expression. Here, we further elucidate its hepatic acid triglyceride (TG) lncRNA regulatory mechanism. The most prominent target of lnc-HC by vitro study PPARγ. Further...
Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes, yet the mechanisms are not completely understood. Here, we demonstrated that serum LPS levels were significantly higher newly diagnosed diabetic patients than normal control. miR-145 level peripheral blood mononuclear cells decreased diabetics. repressed transcription of miR-143/145 cluster levels. Attenuation activity by anti-miR-145 triggered liver increased chemokines C57BL/6 J mice. Conversely,...
A high-throughput systematic evolution of ligands by exponential enrichment assay was applied to 371 putative TFs in Pseudomonas aeruginosa, which resulted the robust 199 unique sequence motifs describing binding specificities 182 TFs. By scanning genome, we predicted total 33,709 significant interactions between and their target loci, were more than 11-fold enriched intergenic regions but depleted gene body regions. To further explore delineate physiological pathogenic roles P. constructed...