A5100368469- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Immune cells in cancer
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- Ferroptosis and cancer prognosis
- Neuropeptides and Animal Physiology
- Cancer Immunotherapy and Biomarkers
- Barrier Structure and Function Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Immunotherapy and Immune Responses
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Random Matrices and Applications
- Blood Coagulation and Thrombosis Mechanisms
- Fetal and Pediatric Neurological Disorders
- Hormonal and reproductive studies
Huizhou Central People's Hospital
2025
Guangxi Medical University
2024
First Affiliated Hospital of Zhengzhou University
2018-2024
State Key Laboratory of Medical Neurobiology
2020-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Fudan University
2018-2024
Huashan Hospital
2010-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Huadong Hospital
2021-2024
First Affiliated Hospital of GuangXi Medical University
2024
Abstract Objective Chinese Herb QingBai decoction (QBD) has been approved affective in the treatment of IBD patients clinic. However, underlying mechanism remains unknown. We aim to investigate effect QBD on mouse model ulcerative colitis and its possible mechanism. Methods C57/bL mice were given 5% DSS induce divided as mesalazine group. Weight, faeces mental status recorded each day histopathological changes (goblet cells etc) colon observed after sacrificed. Fluorescein...
Notoginsenoside R1 (NGR1) is a predominant phytoestrogen extracted from Panax notoginseng that has recently been reported to play important roles in the treatment of cardiac dysfunction, diabetic kidney disease, and acute liver failure. Studies have suggested NGR1 may be viable hypoxic-ischemic brain damage (HIBD) neonates by reducing endoplasmic reticulum stress via estrogen receptors (ERs). However, whether other neuroprotective mechanisms or long-term effects unclear. In this study,...
Microglia/macrophages are activated after cerebral ischemic stroke and can contribute to either brain injury or recovery by polarizing microglia/macrophage into distinctive functional phenotypes with pro- anti-inflammatory properties. Interleukin-13 (IL-13) is an cytokine that regulates polarization toward phenotype. However, it not clear whether IL-13 beneficial long-term the underlying molecular mechanism(s) remain unknown. Thus, we examined effect of on in mice transient middle artery...
The accumulation of self-renewed polarized microglia in the penumbra is a critical neuroinflammatory process after ischemic stroke, leading to secondary demyelination and neuronal loss. Although known regulate tumor cell proliferation neuroinflammation, HDAC3's role microgliosis microglial polarization remains unclear. We demonstrated that HDAC3 knockout (HDAC3-miKO) ameliorated poststroke long-term functional histological outcomes. RNA-seq analysis revealed mitosis as primary affected...
Abstract Cancer immunotherapeutic agents (vaccines) in the form of antigen‐loaded dendritic cells (DCs) reached an important milestone with recent approval Provenge, first DC vaccine for treatment prostate cancer. Although this heralds a new era tumor immunotherapy, it also highlights compelling need to optimize such DC‐based therapies as they are increasingly tested and used treat human patients. In study we sought augment enhance antitumor activity using siRNA silence expression...
Microglia play essential roles in neuroinflammatory responses after traumatic brain injury (TBI). Our previous studies showed that phenotypes of microglia, as well infiltrating macrophages, altered at different stages CNS injury, which was correlated to functional outcomes. IL-13 is an anti-inflammatory cytokine has been reported protect against demyelination and spinal cord through immunomodulation. The effects microglia/macrophage-mediated immune TBI remain unknown. In this study, we...
Abstract Background Erectile dysfunction (ED) is associated with inflammation. The systematic immune‐inflammation index (SII), as a new inflammation marker, was applied to predict the risk of diseases. However, no research explores relationship between SII and ED. Hence, purpose this study investigate association Methods Related data were obtained from National Health Nutrition Examination Survey (NHANES) 2001−2004. Based on self‐report, all participants classified into ED non‐ED group....
Background Although tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses many solid tumors, precise mechanisms by which TLSs enhance immunity remain poorly understood. The current study aimed to explore relationship between maturity of their key cells combating breast cancer. Patients methods In this study, we utilized immunofluorescence H&E staining detect tumor-resident memory T (Trm) assess TLS,...
Background: In a previous study, we found that melatonin inhibits MG-63 osteosarcoma cell proliferation; however, the underlying mechanisms remain elusive. Mitogen-activated protein kinase (MAPK) and Akt signaling pathways play key roles in anticancer effects of melatonin. Aims: The present study investigated whether MAPK are involved melatonin's antiproliferative actions on human cells. Methods/Results: Western blot analysis confirmed significantly inhibited phosphorylation ERK1/2 but not...
MicroRNAs (miRNAs) are endogenous, non-coding RNAs, which exert crucial functions in regulating biological progressions. Previous studies have demonstrated the anti-tumor effect of miRNA-215-5p. However, its specific role influencing progression prostate cancer (PCa) remains unclear. This study aims to uncover regulatory miRNA-215-5p on metastasis and prognosis PCa.
// Saman Maleki Vareki 1,5 , Mateusz Rytelewski Rene Figueredo 5 Di Chen 2 Peter J. Ferguson 3,5 Mark Vincent Weiping Min Xiufen Zheng and James Koropatnick 1,2,3,4,5 1 Department of Microbiology Immunology, Western University, London, Ontario, Canada Pathology, 3 Oncology, 4 Physiology Pharmacology, Cancer Research Laboratory Program, Lawson Health Institute, Correspondence: Koropatnick, email: Keywords : IDO- PARP- OLAPARIB- RADIATION- CISPLATIN- BRCA2 Received March 11, 2014 Accepted...
Cancer cells commonly have metabolic abnormalities. Aside from altered glucose and amino acid metabolism, cancers often share the attribute of fatty alterations. However, metabolism related-gene set has not been systematically investigated in gliomas. Here, we provide a bioinformatic profiling catabolic metabolism-related gene risk signature for malignancy, prognosis immune phenotype glioma. In this study, cohort 325 patients with whole genome RNA-seq expression data Chinese Glioma Genome...
Osthole is a bioactive coumarin derivative and has been reported to be able enhance bone formation improve fracture healing.However, the molecular mechanism of in healing not fully defined.In this study we determined if enhances through activation BMP2 signaling mice.We performed unilateral open transverse tibial procedure 10-week-old C57BL/6 mice which were treated with or without Osthole.Our previous studies demonstrated that chondrocyte BMP required for healing, also Cre-negative...
A multidimensional inflammatory response ensues after status epilepticus (SE), driven partly by cyclooxygenase-2-mediated activation of prostaglandin EP2 receptors. The is typified astrocytosis, microgliosis, erosion the blood-brain barrier (BBB), formation cytokines, and brain infiltration blood-borne monocytes. Our previous studies have shown that inhibition monocyte invasion or systemic administration an receptor antagonist relieves multiple deleterious consequences SE. Here we identify...
Background and Purpose Cancer cachexia cancer‐associated thrombosis are potentially fatal outcomes of advanced cancer. Nevertheless, thrombin expression in non‐small cell lung cancer (NSCLC) primary tumour tissues the association between prognosis NSCLC patients remain largely unknown. Experimental Approach Clinical pathological analysis was performed to determine relationship progression. Effects r‐hirudin direct inhibitor peptide (DTIP) on progression were evaluated. Western blotting,...
The embolic middle cerebral artery occlusion (eMCAO) model mimics ischemic stroke due to large vessel in humans and is amenable thrombolytic therapy with rtPA. However, two major obstacles, the difficulty of eMCAO surgery unpredictable occurrence clot autolysis, had impeded its application mice. In this study, we modified catheters produce suitable fibrin-rich embolus optimized using blood flow (CBF) monitored by both laser Doppler flowmetry (LDF) 2D speckle contrast imaging (LSCI) confirm...
Adiponectin is a protein hormone secreted exclusively by adipocytes that plays an important role in the modulation of glucose and lipid metabolism. In present study, we investigated ability adiponectin to stimulate chicken preadipocyte differentiation its effect on cellular signaling pathways associated with adipocyte differentiation. Data showed over-expression inhibited expression adipogenic marker gene, while activated lipolytic gene. Meanwhile, led activation p38 mitogen-activated kinase...
Previous studies suggested that anti-inflammatory microglia/macrophages (Mi/MΦ) play a role in "normal phagocytosis," which promoted the rapid clearance of necrotic substances and apoptotic cells. More recently, few have found Mi/MΦ also "pathological phagocytosis" form excessive or reduced phagocytosis, thereby worsening damage induced by CNS diseases. However, underlying mechanisms subtypes related to this pathological phagocytosis are still unknown. Salt-inducible kinase 3 (SIK3), member...