A5101693962- Pulmonary Hypertension Research and Treatments
- Fatigue and fracture mechanics
- Nitric Oxide and Endothelin Effects
- Advanced Chemical Physics Studies
- High Temperature Alloys and Creep
- Non-Destructive Testing Techniques
- Hydrogen embrittlement and corrosion behaviors in metals
- PI3K/AKT/mTOR signaling in cancer
- High-Temperature Coating Behaviors
- Spectroscopy and Laser Applications
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Mass Spectrometry Techniques and Applications
- Laser-induced spectroscopy and plasma
- Bone and Joint Diseases
- Aluminum Alloy Microstructure Properties
- Cancer, Hypoxia, and Metabolism
- Atomic and Molecular Physics
- Protein Tyrosine Phosphatases
- Peptidase Inhibition and Analysis
- Nuclear Engineering Thermal-Hydraulics
- Aluminum Alloys Composites Properties
- Eicosanoids and Hypertension Pharmacology
- MicroRNA in disease regulation
Suzhou Research Institute
2014-2024
Jiangsu Vocational College of Medicine
2023
Armed Forces Capital Hospital
2023
China Medical University
2005-2022
Sichuan University
2020-2022
West China Hospital of Sichuan University
2021-2022
Suzhou Municipal Hospital
2022
Nanjing Medical University
2018-2022
Jiangsu Province Hospital
2018-2022
Chenzhou First People's Hospital
2022
Nanoparticles have attracted increasing attention for local drug delivery to the inner ear recently. Bovine serum albumin (BSA) nanoparticles were prepared by desolvation method followed glutaraldehyde fixation or heat denaturation. The spherical in shape with an average diameter of 492 nm. heat-denatured had good cytocompatibility. could adhere on and penetrate through round window membrane guinea pigs. analyzed as carriers investigate loading capacity release behaviors. Rhodamine B was...
Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic advanced that highly related to metabolic disorders and induced by high-fat diet (HFD). Recently, epigallocatechin gallate (EGCG) has been regarded as protective bioactive polyphenol in green tea the ability protect against non-alcoholic disease, but molecular mechanism remains poorly deciphered. Ferroptosis plays vital role progression of experimental evidence ferroptosis inhibition limited. Hence, our study aimed...
Increasing evidences suggest that angiotensin (Ang) II participates in the pathogenesis of endothelial dysfunction (ED) through multiple signaling pathways, including type 1 receptor (AT1R) mediated NADPH oxidase (Nox)/reactive oxygen species (ROS) signal transduction. However, detailed mechanism is not completely understood. In this study, we reported AngII/AT1R-mediated activated protein phosphatase 2A (PP2A) downregulated nitric oxide synthase (eNOS) phosphorylation via Nox/ROS pathway....
In Brief BACKGROUND: Intravascular volume therapy is crucial in septic patients to improve tissue perfusion and maintain stable hemodynamics. Modified fluid gelatins (MFG) medium weight hydroxyethyl starches (HES) are the most widely used synthetic colloids. Our aim this study, performed rats challenged by cecal ligation puncture (CLP), was investigate effects of HES MFG on pulmonary capillary leakage determine whether an antiinflammatory mechanism involved. METHODS: Animals were randomly...
The ir photolysis of C2H3CN, producing C2[a 3πu(v=0)] via sequential photodissociation processes, is studied using laser induced fluorescence to measure the time flight spectrum recoiling C2 photofragments. This technique measures recoil velocity distribution for particular energy states, and can be applied study a number elementary processes. average photofragment 1.1±0.3 kcal/mole, this includes contributions from along reaction coordinate as well rotational motion in precursor.
Pulmonary arterial hypertension (PAH) characterized by pulmonary vascular remodeling is a lethal disease.Paeoniflorin (PF) monoterpene glycoside with numerous beneficial functions, such as vasodilation, anti-inflammation and immunomodulation.This study aims to investigate the effects of PF on monocrotaline (MCT)-induced PAH rats.Our data showed that both prophylactic or therapeutic administration alleviated MCT-induced increasing right ventricular systolic pressure (RVSP), prevented...
Pulmonary hypertension (PH) is a progressive disease leading to death ultimately. Our recently published data demonstrated that inhibiting dipeptidyl peptidase IV (DPP-4) alleviated pulmonary vascular remodeling in experimental PH. However, whether glucagon-like peptide-1 (GLP-1) mediated the protective effect of DPP-4 inhibition (DPP-4i) on PH unclear.In present study, GLP-1 receptor antagonist (exendin-3) abolished effects inhibitor (sitagliptin) right ventricular systolic pressure (RVSP)...
Background and Purpose Cancer cachexia cancer‐associated thrombosis are potentially fatal outcomes of advanced cancer. Nevertheless, thrombin expression in non‐small cell lung cancer (NSCLC) primary tumour tissues the association between prognosis NSCLC patients remain largely unknown. Experimental Approach Clinical pathological analysis was performed to determine relationship progression. Effects r‐hirudin direct inhibitor peptide (DTIP) on progression were evaluated. Western blotting,...
Ketamine is reported to suppress production of proinflammatory cytokines and activity nuclear factor-kappa B (NF-kappaB) after lipopolysaccharide (LPS) stimulation. Our study was designed investigate the effects ketamine on pulmonary inflammatory responses survival in a clinically relevant model polymicrobial sepsis, induced by cecal ligation puncture (CLP).After induction sepsis or sham-operation, animals were treated with (0.5, 5 10 mg/kg) saline (10 ml/kg) at 3h operation. At 6 h...
Macrophage accumulation and activation contribute to the development of pulmonary arterial hypertension (PAH), while Bruton’s tyrosine kinase (BTK) is an important regulator for polarization macrophage. However, role BTK in PAH remains unknown. In present study, a selective inhibitor (BTKi) BGB-3111 was applied investigate monocrotaline- (MCT-) induced rat phorbol myristate acetate- (PMA-) differentiated U937 macrophages. Our results showed that mainly distributed upregulated CD68+...
It is shown that C2 formed in the a3πu state via ir photodissociation of selected polyatomic molecules absence collisional processes.
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma that has been found to induce matrix metalloproteinase-9 (MMP-9) activation and result in eventual retinal dysfunction. Proinflammatory cytokines such as monocyte chemoattractant protein-1 (MCP-1) interleukin-1β (IL-1β) were also be involved disease progression by mediating MMP-9 production. We previously reported fungal derivative theissenolactone C (LC53) could exert ocular protective effects suppressing...
Src homology 2 containing protein tyrosine phosphatase (PTP) (Shp2) is a typical interacting with receptor kinase to regulate multiple signaling pathways in diverse pathological processes. Here, we will investigate the effect of Shp2 inhibition on pulmonary arterial hypertension (PAH) rat model and its potential cellular molecular mechanisms underlying. Monocrotaline (MCT)-induced PAH was used this study. Phps-1, highly selective inhibitor for Shp2, administered from 21 days 35 after MCT...
Endothelial cells dysfunction is one of the hallmark pathogenic features pulmonary arterial hypertension (PAH). Paeoniflorin (PF) a monoterpene glycoside with endothelial protection, vasodilation, antifibrotic, anti-inflammatory and antioxidative properties. However, effects PF on PAH remain unknown.Here, we investigated efficacy in SU5416/hypoxia (SuHx) rat model PAH. Human (HPAECs) were exposed to 1% O2 or without treatment.Hemodynamics analysis showed that prophylactic treatment (300...
C2(a) and CN(X) radicals have been detected by laser induced fluorescence in the collision-free infrared multiple photon decomposition of C2H3CN. Fluence dependence measurements suggest a common precursor for these while spectrally temporally resolved data show that amount energy is partitioned among products small. The results are consistent with dominant kinetic scheme, based on RRKM arguments thermodynamic data, which C2H3CN decomposes mainly loss H2 and/or H. resulting C3N then fragments...
ABSTRACT Targeted drug delivery is particularly important in cancer treatment because many antitumor drugs are nonspecific and highly toxic to both cancerous normal cells. The L33 aptamer a single‐stranded DNA (ssDNA) sequence that has the ability recognize human colorectal (CRC) cell line HCT116 specifically. In this study, we demonstrated can selectively internalize into target cells via receptor‐mediated endocytosis. Based on finding, developed an aptamer‐based system using as carrier of...
Purpose: Multidrug-resistant tuberculosis (MDR-TB) remains a challenge of global TB control, with difficulty in early detection drug-sensitive (DS-TB). We investigate the diagnostic significance IDO as potential biomarker to discriminate MDR patients among patients. Patients and methods: Plasma indoleamine 2,3-dioxygenase (IDO) was measured by ratio kynurenine (Kyn) tryptophan (Trp) concentrations, using high performance liquid chromatography-mass spectrometry (LC-MS/MS). Chest computed...
Objective: To investigate the incidence of oral infection with Helicobacter pylori (H. pylori) and identify related epidemiological factors among freshmen four colleges in Yancheng.Methods: The data, scored positive or negative, were collected on 160 individuals who had been diagnosed by H. Saliva Test Cassette (HPS) during October 2013 to 2014. is use colloidal gold technique specifically urease saliva. A standard questionnaire, variables including sex, educational degree parents etc., was...