A5011452659- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Peptidase Inhibition and Analysis
- Chronic Myeloid Leukemia Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac tumors and thrombi
- Platelet Disorders and Treatments
- Adolescent and Pediatric Healthcare
- Gastric Cancer Management and Outcomes
- Advancements in Transdermal Drug Delivery
- Metabolism and Genetic Disorders
- Sexual Differentiation and Disorders
- Cancer-related gene regulation
- Bee Products Chemical Analysis
- Cancer-related molecular mechanisms research
- Anesthesia and Pain Management
- Resilience and Mental Health
- Click Chemistry and Applications
- Cancer survivorship and care
- Synthesis and biological activity
- Cervical Cancer and HPV Research
- Family Support in Illness
- Pancreatic and Hepatic Oncology Research
Fudan University
2020-2025
Xinjiang Medical University
2024
Qingdao University
2014
Qingdao Municipal Hospital
2014
Kunming Medical University
2009
Sixth Affiliated Hospital of Kunming Medical University
2009
Tumor cells transform into endothelial by epithelial-to-mesenchymal transition, which is characterized vasculogenic mimicry (VM). VM not only accelerates tumor progression but also increases drug-induced resistance. However, very little currently known about the molecular determinants that enable VM. Targeting might bring a new breakthrough in cancer treatment. Thrombin key enzyme of blood coagulation system and could contribute to progression. Nevertheless, association between thrombin...
Cardiovascular disease is the leading cause of global mortality, with anticoagulant therapy being main prevention and treatment strategy. Recombinant hirudin (r-hirudin) a direct thrombin inhibitor that can potentially prevent thrombosis via subcutaneous (SC) intravenous (IV) administration, but there risk haemorrhage SC IV. Thus, microneedle (MN) provides painless sanitary alternatives to syringes oral administration. However, current technological process for micro mould complicated...
Isthmin-1 (ISM1), a secretory protein predominantly derived from brown adipose tissue, enhances glucose tolerance and attenuates hepatic steatosis. However, its potential involvement in white tissue remodelling remains elusive, which profoundly impacts adipocyte insulin sensitivity consequently alters systemic metabolic homeostasis. ISM1 expression profiles human mouse were systematically characterized using Tabula Sapiens. With the intervention of expression, preadipocyte cell lines...
Background and Purpose Cancer cachexia cancer‐associated thrombosis are potentially fatal outcomes of advanced cancer. Nevertheless, thrombin expression in non‐small cell lung cancer (NSCLC) primary tumour tissues the association between prognosis NSCLC patients remain largely unknown. Experimental Approach Clinical pathological analysis was performed to determine relationship progression. Effects r‐hirudin direct inhibitor peptide (DTIP) on progression were evaluated. Western blotting,...
Currently, anticoagulants would be used to prevent thrombosis. Thrombin is an effector enzyme for haemostasis and We designed a direct thrombin inhibitor peptide (DTIP) using molecular simulation homology modelling demonstrated that the C-terminus of DTIP interacts with exosite I, N-terminus activity site thrombin, respectively. interfered thrombin-mediated coagulation in human, rat mouse plasma (n=10 per group) blocked clotting human whole blood vitro. When administered subcutaneously,...
Background: We investigated the mediating role of personality compatibility, couple communication, and sexual life in psychological resilience marital satisfaction women with breast cancer. Methods: This is a cross-sectional survey. From March 2022 to June 2022, we enrolled 212 cancer from tertiary tumor hospital Xinjiang, China using convenient sampling method. The basic information patients was collected. marriage quality were assessed Enrich Marital Inventory Connor-Davidson scale,...
Objective To observe the characteristic of precancerous lesions and early gastric carcinoma with narrow belt imaging technology. Methods The 74 patients were enrolled in this study. same case was used as self-control. operation made pain-less under anesthesia. When mirror advanced to duodenal descending segment, an ordinary microscope mode back Mallory, found recorded, image zoomed low-fold observed (1.4,1.6,1.8 times). Suspicious collected biopsies made. Results Chronic gastritis could be...