A5101594534- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pulmonary Hypertension Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Infectious Diseases and Tuberculosis
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Reconstructive Facial Surgery Techniques
- Organ and Tissue Transplantation Research
- Eicosanoids and Hypertension Pharmacology
- Immune Response and Inflammation
- Data-Driven Disease Surveillance
- Liver Disease and Transplantation
- COVID-19 diagnosis using AI
- Immunotherapy and Immune Responses
- Traditional and Medicinal Uses of Annonaceae
- Cardiac Valve Diseases and Treatments
- Viral gastroenteritis research and epidemiology
- Medicinal Plant Pharmacodynamics Research
- Plant-derived Lignans Synthesis and Bioactivity
- Traditional Chinese Medicine Analysis
- Viral Infections and Immunology Research
- Child Therapy and Development
- Hypothalamic control of reproductive hormones
- Sepsis Diagnosis and Treatment
PharmacoGenetics (China)
2024
Harvard Global Health Institute
2024
Harvard University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Southwest Medical University
2023
Nanjing Medical University
2010-2022
Jiangsu Province Hospital
2010-2022
Nankai University
2021
Union Hospital
2020
Huazhong University of Science and Technology
2020
Pulmonary arterial hypertension (PAH) characterized by pulmonary vascular remodeling is a lethal disease.Paeoniflorin (PF) monoterpene glycoside with numerous beneficial functions, such as vasodilation, anti-inflammation and immunomodulation.This study aims to investigate the effects of PF on monocrotaline (MCT)-induced PAH rats.Our data showed that both prophylactic or therapeutic administration alleviated MCT-induced increasing right ventricular systolic pressure (RVSP), prevented...
Endothelial cells dysfunction is one of the hallmark pathogenic features pulmonary arterial hypertension (PAH). Paeoniflorin (PF) a monoterpene glycoside with endothelial protection, vasodilation, antifibrotic, anti-inflammatory and antioxidative properties. However, effects PF on PAH remain unknown.Here, we investigated efficacy in SU5416/hypoxia (SuHx) rat model PAH. Human (HPAECs) were exposed to 1% O2 or without treatment.Hemodynamics analysis showed that prophylactic treatment (300...
Multidrug-resistant tuberculosis (MDR-TB) is a hard-to-treat disease with poor outcome of chemotherapy. In the present study, efficacy and safety recombinant human interleukin-2 (rhIL-2) were investigated in patients MDR-TB.Fifty culture-confirmed MDR-TB included. Twenty-five randomly assigned to trial group (injection 500 000 IU rhIL-2 once every other day at first, third, fifth seventh months addition standard multidrug therapy) another 25 control therapy. All monitored clinically, T-cell...
Purpose: Multidrug-resistant tuberculosis (MDR-TB) remains a challenge of global TB control, with difficulty in early detection drug-sensitive (DS-TB). We investigate the diagnostic significance IDO as potential biomarker to discriminate MDR patients among patients. Patients and methods: Plasma indoleamine 2,3-dioxygenase (IDO) was measured by ratio kynurenine (Kyn) tryptophan (Trp) concentrations, using high performance liquid chromatography-mass spectrometry (LC-MS/MS). Chest computed...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening clinical conditions predominantly arising from uncontrolled inflammatory reactions. It has been found that the administration of astaxanthin (AST) can exert protective effects against lipopolysaccharide (LPS)-induced ALI; however, robust genetic signatures underlying LPS induction AST treatment remain obscure. Here we performed a statistical meta-analysis five publicly available gene expression...
It is urgent to find an optimised therapy regimen for the control of MDR-TB globally. This study aimed evaluate efficiacy and safety a combined rhIL-2 injection standard chemotherapy within 18-month duration in randomized controlled trial conducted 14 centres eastern China. From Jan. 2009 July. 2016, 271 cases were enrolled followed up two groups, 142 group while 129 group. Clinical efficacy, immune activity (Th1, Th17, Treg, IFN-γ, IL-17) among groups evaluated compared. After 24-month...
Nonsyndromic hearing loss (NSHL) is a genetically diverse, highly heterogeneous condition characterised by deafness, and Gasdermin E (GSDME) variants have been identified as directly inducing autosomal dominant NSHL. While many NSHL cases associated with GSDME involve the skipping of exon 8, there another, less understood pathogenic insertion variant specifically found in Chinese pedigrees that causes known 5 (DFNA5) loss. In this study, we recruited large pedigree, conducted whole-exome...
Exosomes are 60–120 nm diameter double-membrane lipid organelles discharged by cells. Various studies have shown that exosomes exert multiple functions in both physical and diseased processes, such as intercellular information exchange, immune response, disease progression. Repeated chronic injury to the liver often leads inflammation fibrosis (LF), a disorder that, if unchecked, may progress cirrhosis, failure, portal hypertension, even hepatocellular carcinoma. As an essential component of...
Abstract The World Health Organization's end TB strategy promotes the use of symptom and chest radiograph screening for tuberculosis (TB) disease. However, asymptomatic early states beyond latent infection active disease can go unrecognized using current criteria. We conducted a longitudinal cohort study enrolling household contacts initially free followed them occurrence incident over 1 year. Among 1,747 screened contacts, 27 (52%) 52 persons in whom subsequently developed during follow-up...
The CYP2D6 enzyme is crucial for the metabolism and disposition of a variety drugs. This study was conducted to examine relationship between gene polymorphisms response angiotensin receptor blocker (ARB)-based treatment in patients Chinese Bai ethnicity with hypertension.
Hepatocellular carcinoma (HCC) is a highly aggressive tumor with limited treatment options and high mortality. Senecavirus A (SVA) has shown potential in selectively targeting tumors while sparing healthy tissues. This study aimed to investigate the effects of SVA on HCC cells
Akebia trifoliata subsp. australis (Diels) T.Shimizu is a medicinal plant in China. Here, the complete chloroplast (cp) genome sequence of A. was assembled and characterized as resource for future genetic studies. The whole cp 157,952 bp length, containing large single-copy (LSC) region 86,596 bp, small (SSC) 19,060 two inverted repeat (IR) regions 26,148 bp. new possessed total 113 unique genes, including 79 protein-coding 30 tRNA genes 4 rRNA genes. nucleotide composition asymmetric (30.3%...
Objective: To reexamine literature and data on the effects of gene polymorphism precocious puberty via a meta-analysis. Methods: Consultation search engines Chinese Bio-medicine Database, China National Knowledge Infrastructure, Pubmed Medline resulted in total seven studies containing more than 4300 individuals from various ethnic backgrounds. evaluate risk puberty, odds ratios (OR) for all case-control were calculated. Results: In this meta-analysis no significant association with combined...
Public goods are non-exclusive and non-competitive commodities. Because of this characteristic, the government has become main body providing public in most cases. However, at present, problems such as low efficiency waste resources process goods. Based on perspective choice theory, article analyzes why failures occur goods, proposes path reconstruction suggestions.
Objective To introduce the sm＇gical procedure of reconstructing distal segment thumb using combined bilateral big toe wrap-around flap. Methods A partial fibular side flap was harvested from both toes. The flaps were tailored and designed based on measurements taken intact side. These two like ＂nfirror image＂ to reconstruct thumb. Results This technique used in 6 thumbs cases. All transplants survived. patients follow-up for 3 9 months. reconstructed had full pulp. Two-point discrimination...
Objective To explore the surgical method of applying free lateral arm flap in replantation complex thumb severance and report clinical outcomes.Methods From June 2007 to December 2009,9 cases with large size skin defect were treated.The was harvested applied bridge tissue severance.The radial collateral vessel used establish blood supply replanted thumb.The posterior brachial cutaneous nerves included repaired restore sensation sizes flaps ranged from 6.5 cmx 4.5 cm 11.0 cm.Blood vessels...