A5100670779- Viral Infections and Vectors
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Cancer-related gene regulation
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Insect-Plant Interactions and Control
- Insect Resistance and Genetics
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Heart Rate Variability and Autonomic Control
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Insect and Pesticide Research
- Insect and Arachnid Ecology and Behavior
- Plant-Microbe Interactions and Immunity
- Sepsis Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Alzheimer's disease research and treatments
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Third Xiangya Hospital
2024-2025
Central South University
2020-2025
China XD Group (China)
2023-2025
Guangzhou Blood Center
2021-2025
Lishui Academy of Forestry
2022-2025
First Affiliated Hospital of Henan University
2025
First Hospital of Jilin University
2018-2024
ZheJiang Academy of Agricultural Sciences
2022-2024
Institute of Plant Protection
2022-2024
BACKGROUND Throughout China, during the recent epidemic in Hubei province, frontline medical staff have been responsible for tracing contacts of patients infected with coronavirus disease 2019 (COVID‑19). This study aimed to investigate psychological impact and coping strategies Hunan adjacent COVID‑19 outbreak between January March 2020. MATERIAL AND METHODS A cross-sectional observational included doctors, nurses, other hospital throughout province The questionnaire five sections 67...
To better understand intrinsic resistance to immune checkpoint blockade (ICB), we established a comprehensive view of the cellular architecture treatment-naive melanoma ecosystem and studied its evolution under ICB. Using single-cell, spatial multi-omics, showed that tumor microenvironment promotes emergence complex transcriptomic landscape. Melanoma cells harboring mesenchymal-like (MES) state, population known confer targeted therapy, were significantly enriched in early on-treatment...
Polycomb Repressive Complex 2 (PRC2) modulates the chromatin structure and transcriptional repression by trimethylation lysine 27 of histone H3 (H3K27me3), a process that necessitates protein–protein interaction (PPI) between catalytic subunit EZH2 EED. Deregulated PRC2 is intimately involved in tumorigenesis progression, making it an invaluable target for epigenetic cancer therapy. However, until now, there have been no reported small molecule compounds targeting EZH2-EED interactions. In...
It is well established that the presence of soluble amyloid-beta protein (Abeta) correlates with severity dementia in Alzheimer's disease (AD). Several lines evidence indicate cyclic AMP responsive element binding (CREB) and kinase A (PKA) are involved Abeta-trigged disruption synaptic plasticity early AD. Previously we demonstrated beneficial effects ginsenoside Rg1 on Abeta-induced neuronal insult. Therefore, present study, examined long-term consumption cerebral Abeta content PKA/CREB...
The Hedgehog (Hh) signaling pathway plays critical roles in modulating embryogenesis and maintaining tissue homeostasis, with glioma-associated oncogene (GLI) transcription factors being the main mediators. Aberrant activation of this is associated various human malignancies including glioblastoma, although mechanistic details are not well understood. We performed a microarray analysis genes that differentially expressed glioblastoma U87 cells overexpressing GLI2A, active form GLI2, relative...
Acute spinal cord injury (SCI) leads to permanent disabilities. This study evaluated the neuroprotective effect of puerarin, a natural extract, in rat model SCI.Acute SCI models were established rats using modified Allen's method. Locomotor function was BBB test. The histological changes observed by H&E staining. Neuron survival and glial cells activation immunostaining. ELISA realtime PCR used measure secretion gene expression cytokines. TUNEL staining examine cell apoptosis western...
Inflammation-related diseases affect large populations of people in the world and cause substantial healthcare burdens, which results significant costs time, material, labor. Preventing or relieving uncontrolled inflammation is critical for treatment these diseases. Herein, we report a new strategy alleviating by macrophage reprogramming via targeted reactive oxygen species (ROS) scavenging cyclooxygenase-2 (COX-2) downregulation. As proof concept, synthesize multifunctional compound named...
The fall armyworm (FAW) Spodoptera frugiperda is a destructive and polyphagous pest of many essential food crops including maize rice. FAW hard to manage, control, or eradicate, due its nature voracity feeding. Here, we report the characterization functional analysis detoxification gene CYP302A1 how S. frugieprda larvae use mechanism adapt host plants. Results demonstrated that expression levels were much higher in midgut tissue older larvae. Our current studies revealed enhanced P450...
Abstract Background Plant U-box (PUB) E3 ubiquitin ligases have vital effects on various biological processes. Therefore, a comprehensive and systematic identification of the members gene family in potato will help to understand evolution function plants. Results This work identified altogether 74 PUBs (StPUBs) examined their structures, chromosomal distributions, conserved motifs. There were seventy-four StPUB genes ten chromosomes with diverse densities. As revealed by phylogenetic...
Abstract Background NARS2 as a member of aminoacyl-tRNA synthetases was necessary to covalently join specific tRNA its cognate amino acid. Biallelic variants in were reported with disorders such Leigh syndrome, deafness, epilepsy, and severe myopathy. Case presentation Detailed clinical phenotypes collected the discovered by whole exome sequencing verified Sanger sequencing. Additionally, 3D protein structure visualization performed UCSF Chimera. The proband our study had early-onset status...
Background: Black tea processing conditions significantly affect the final taste and flavor profiles, so researchers are now focusing on developing equipment improving appropriate of major black varieties. Methods: Here, we tested effect four different initial drying temperatures, i.e., R65 (65 °C), R85 (85 R105 (105 R125 (125 sensory biochemical profiles volatilome variety “Lishui wild” (LWV). Results: Our results indicate that both 85 105 °C better than 65 125 for 20 min. had highest...
While electroacupuncture (EA) has shown effectiveness in treating learning and memory deficits associated with ischemic stroke (IS), the specific mechanisms involved remain unclear. The goal of this study was to investigate whether EA improves MCAO rats by regulating microglia/macrophage polarization through nuclear factor red lineage 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. Sprague-Dawley were subjected modeling treated 24 hours post-MCAO for a period two weeks. To...
Hepatic fibrosis may progress to liver cirrhosis and eventually cause death. Epithelial-mesenchymal transition (EMT) of hepatocytes plays critical roles in hepatic fibrosis. Exploring the mechanisms underlying EMT is crucial for a better understanding pathogenesis. Hepatocyte wad induced with TGF-β1 evaluated by Western blotting immunofluorescence staining. Methylated RNA immunoprecipitation (MeRIP) was applied assess N6-methyladenosine (m6A) modification. RIP pull-down assays were performed...
ABSTRACT Acute hepatitis C (AHC) represents a considerable challenge to global public health, although direct‐acting antiviral (DAA) therapy has substantially improved therapeutic outcomes for virus infection. Data were exclusively obtained from the 2021 Global Burden of Disease (GBD) study, which examined trends in burden AHC terms incidence, mortality and disability‐adjusted life years (DALYs) across 204 countries territories globally 2009 2021. In 2021, there 7,009,910.02 incident cases,...
Abstract The connection between inflammation and tumourigenesis has been well established. However, the detailed molecular mechanism underlying inflammation-associated remains unknown because this process involves a complex interplay immune microenvironments epithelial cells. To obtain more systematic understanding of as to identify novel therapeutic approaches, we constructed knowledge-based network describing development colitis-associated colon cancer (CAC) by integrating extracellular...
The M2 subtype Acute Myeloid Leukemia (AML-M2) with t(8;21) represents an unmet challenge because of poor clinical outcomes in a sizable portion patients. In this study,we report that FTY720 (Fingolimod), sphingosine analogue and FDA approved drug for treating multiple sclerosis, shows antitumorigenic activity against the Kasumi-1 cell line, xenograft mouse models leukemic blasts isolated from AML-M2 patients translocation. Primary investigation indicated caused apoptosis through caspases...
Background: 2′, 5′-oligoadenylate synthetase 2 (OAS2) has been known as an antiviral interferon-stimulated gene (ISG). However, the role of OAS2 on Zika virus (ZIKV) replication is still unknown. In this study, we sought to explore effect ZIKV and its underlying mechanism. Methods: We performed RNA-Seq in A549 cells with or without infection. RIG-I was overexpressed by plasmid transfection knocked down siRNA cells. Expression levels mRNA protein selected genes were detected RT-qPCR Western...
The prevalence and outcomes of patients who had re-activation coronavirus disease 2019 (COVID-19) after discharge remain poorly understood. We included 126 consecutively confirmed cases COVID-19 with 2-month follow-up data in this retrospective study. upper respiratory specimen using a reverse-transcription polymerase chain reaction test three (71 years [60–76]) were positive within 11–20 days their discharge, an event rate 19.8 (95%CI 2.60–42.1) per 1,000,000 patient-days. Moreover, all...
Abstract Background Observational studies have indicated a potential association between autoimmune diseases and the occurrence of sepsis, with an increased risk mortality among affected patients. However, whether causal relationship exists two remains unknown. Methods In Mendelian randomization (MR) study, we accessed exposure Genome-wide study (GWAS) data from both MRC Integrative Epidemiology Unit (MRC-IEU) FinnGen consortium. GWAS for sepsis its 28-day were obtained MRC-IEU. We employed...