A5029399002- Biofuel production and bioconversion
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Gut microbiota and health
- Parasites and Host Interactions
- Microbial Metabolic Engineering and Bioproduction
- Fungal and yeast genetics research
- Parasite Biology and Host Interactions
- Microbial Community Ecology and Physiology
- Marine and coastal plant biology
- Streptococcal Infections and Treatments
- Polar Research and Ecology
- RNA Research and Splicing
- Circular RNAs in diseases
- Neonatal and Maternal Infections
- Protein Degradation and Inhibitors
- Insect Pest Control Strategies
- Neurobiology and Insect Physiology Research
- Cancer Cells and Metastasis
- Protein Kinase Regulation and GTPase Signaling
- Food composition and properties
- Insect and Pesticide Research
- Microbial infections and disease research
- CAR-T cell therapy research
- Infections and bacterial resistance
VIB-KU Leuven Center for Cancer Biology
2024
KU Leuven
2024
Instituto Butantan
2019-2023
Brazilian Center for Research in Energy and Materials
2020-2022
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2020-2021
Universidade de São Paulo
2019-2020
Universidade Federal do Pampa
2018
Universidade Federal de Pelotas
2017
Universidade de Brasília
2014
To better understand intrinsic resistance to immune checkpoint blockade (ICB), we established a comprehensive view of the cellular architecture treatment-naive melanoma ecosystem and studied its evolution under ICB. Using single-cell, spatial multi-omics, showed that tumor microenvironment promotes emergence complex transcriptomic landscape. Melanoma cells harboring mesenchymal-like (MES) state, population known confer targeted therapy, were significantly enriched in early on-treatment...
The largest living rodent, capybara, can efficiently depolymerize and utilize lignocellulosic biomass through microbial symbiotic mechanisms yet elusive. Herein, we elucidate the community composition, enzymatic systems metabolic pathways involved in conversion of dietary fibers into short-chain fatty acids, a main energy source for host. In this microbiota, unconventional machinery from Fibrobacteres seems to drive cellulose degradation, whereas diverse set carbohydrate-active enzymes...
Summary Due to an increasing demand for sustainable agricultural practices, the adoption of microbial volatile organic compounds (VOCs) as antagonists against phytopathogens has emerged eco‐friendly alternative use agrochemicals. Here, we identified three Pseudomonas strains that were able inhibit, in vitro, up 80% mycelial growth phytopathogenic fungus Thielaviopsis ethacetica , causal agent pineapple sett rot disease sugarcane. Using GC/MS, found these bacteria produced 62 different VOCs,...
The trematode parasite Schistosoma mansoni causes schistosomiasis, which affects over 200 million people worldwide. Schistosomes are dioecious, with egg laying depending on the females’ obligatory pairing males. Long non-coding RNAs (lncRNAs) transcripts longer than nucleotides low or no protein-coding potential that have been involved in other species reproduction, stem cell maintenance, and drug resistance. In S . , we recently showed knockdown of one lncRNA status these parasites. Here,...
Long non-coding RNAs (lncRNAs) (>200 nt) are expressed at levels lower than those of the protein-coding mRNAs, and in all eukaryotic model species where they have been characterized, transcribed from thousands different genomic loci. In humans, some four dozen lncRNAs studied detail, shown to play important roles transcriptional regulation, acting conjunction with transcription factors epigenetic marks modulate tissue-type specific programs gene activation repression. Schistosoma mansoni,...
Abstract Schistosoma mansoni is a flatworm that causes schistosomiasis, neglected tropical disease affects more than 200 million people worldwide. There only one drug indicated for treatment, praziquantel, which may lead to parasite resistance emergence. The ribonucleoside analogue 5-azacytidine (5-AzaC) an epigenetic inhibits S. oviposition and ovarian development through interference with transcription, translation stem cell activities. Therefore, studying the downstream pathways affected...
Abstract Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is the most used, fast, and reproducible method to confirm large-scale gene expression data. The use of stable reference genes for normalization RT-qPCR assays recognized worldwide. No systematic study selecting appropriate usage in experiments comparing levels at different Schistosoma mansoni life-cycle stages has been performed. Most studies rely on commonly used other organisms, such as actin ,...
The development of high-performance xylose-fermenting yeast is essential to achieve feasible conversion biomass-derived sugars in lignocellulose-based biorefineries. However, engineered C5-strains Saccharomyces cerevisiae still present low xylose consumption rates under anaerobic conditions. Here, we explore alternative metabolisms involved metal homeostasis, which positively affect C5 fermentation and analyse the non-obvious regulatory network connection both using time-course transcriptome...
Schistosoma japonicum is a flatworm that causes schistosomiasis, neglected tropical disease. S. RNA-Seq analyses has been previously reported in the literature on females and males obtained during sexual maturation from 14 to 28 days post-infection mouse, resulting identification of protein-coding genes pathways, whose expression levels were related development. However, this work did not include an analysis long non-coding RNAs (lncRNAs). Here, we applied pipeline identify annotate lncRNAs...
DATA REPORT article Front. Mol. Biosci., 08 January 2018Sec. RNA Volume 4 - 2017 | https://doi.org/10.3389/fmolb.2017.00089
Cancer cells display distinct, recurrent phenotypic cell states. Metastatic spreading correlates with tumor state evolution. However, the molecular mechanisms underlying metastasis remain elusive. Here, we demonstrate that quantitative dosage of oncogenic KRAS drives lung adenocarcinoma progression and via integration external signaling pioneer transcription factor dynamics into qualitative Combining mouse models, in vivo CRISPR activation screens, fate mapping, show even mild...
The strangles is an infectious disease that affects horses from all ages and causes important economic losses in the equine-related business. aim of this work was to evaluate immunogenicity recombinant M protein Streptococcus equi (rSeM) co-administered with heat-labile enterotoxin B subunit Escherichia coli (rLTB) mice horses. A total 72 female Balb-c were divided into eight groups 18 six groups. animals inoculated by intramuscular (IM) or intranasal (IN) routes different treatments rSeM,...
Abstract Background: Plant biomass is a promising feedstock to replace fossil-based products including fuels, chemicals and materials. However, the high resistance of plant either physicochemical or biological deconstruction has been hampering its broad industrial utilization and, consequently, transition sustainable bioeconomy. The gut system from herbivores are formidable bioreactors in nature for lignocellulose breakdown diverse ecological niches where found have led rise myriad molecular...
Abstract Background Plant biomass is a promising feedstock to replace fossil-based products including fuels, chemicals and materials. However, the high resistance of plant either physicochemical or biological deconstruction has been hampering its broad industrial utilization and, consequently, transition sustainable bioeconomy. The gut system from herbivores are formidable bioreactors in nature for lignocellulose breakdown diverse ecological niches where found have led rise myriad molecular...