A5001692684- Biofuel production and bioconversion
- Antifungal resistance and susceptibility
- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- Genomics and Phylogenetic Studies
- Infectious Diseases and Mycology
- Sugarcane Cultivation and Processing
- Enzyme Production and Characterization
- Genetics, Bioinformatics, and Biomedical Research
- Plant Taxonomy and Phylogenetics
- Cell Image Analysis Techniques
- RNA and protein synthesis mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Molecular Biology Techniques and Applications
- Fermentation and Sensory Analysis
- Wood and Agarwood Research
- Bioenergy crop production and management
- Bacterial Genetics and Biotechnology
- Machine Learning in Bioinformatics
- Bacteriophages and microbial interactions
- Plant and animal studies
- Forest ecology and management
- Fungal and yeast genetics research
- Fungal Infections and Studies
- Plant-Microbe Interactions and Immunity
Universidade de São Paulo
2015-2025
Universidade Estadual de Campinas (UNICAMP)
2021-2024
Universidade de Ribeirão Preto
2020-2023
Vanderbilt University
2020-2021
Nashville Oncology Associates
2021
Instituto de Ciências Farmacêuticas
2020-2021
Brazilian Center for Research in Energy and Materials
2013-2020
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2013-2020
Universidade Estadual Paulista (Unesp)
2015
Universidade Federal de São Carlos
2015
The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens humans, animals and crops, a source potent carcinogenic contaminants food, an genetic model. genome sequences eight aspergilli have already been explored investigate aspects biology, raising questions about evolution specialization within this genus.We generated for ten novel, highly diverse species compared these in detail sister more distant genera....
Second generation (2G) ethanol is produced by breaking down lignocellulosic biomass into fermentable sugars. In Brazil, sugarcane bagasse has been proposed as the residue for this biofuel production. The enzymatic cocktails degradation of biomass-derived polysaccharides are mostly fungi, such Aspergillus niger and Trichoderma reesei. However, it not yet fully understood how these microorganisms degrade plant biomass. order to identify transcriptomic changes during steam-exploded (SEB)...
Fungal pathogens are a global threat to human health. For example, fungi from the genus Aspergillus cause spectrum of diseases collectively known as aspergillosis. Most >200,000 life-threatening aspergillosis infections per year worldwide caused by fumigatus. Recently, molecular typing techniques have revealed that can also be organisms phenotypically similar A. fumigatus but genetically distinct, such lentulus and fumigatiaffinis. Importantly, some these so-called cryptic species thought...
The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of disease 2019 (COVID-19), has already killed millions people. COVID-19 patient outcome can be further complicated secondary infections, such as COVID-19-associated pulmonary aspergillosis (CAPA).
Pulcherrimin is an iron-binding reddish pigment produced by various bacterial and yeast species. In the soil bacterium Bacillus subtilis, this synthesized intracellularly as colorless pulcherriminic acid using two molecules of tRNA-charged leucine substrate; are then secreted bind to ferric iron extracellularly form red-colored pulcherrimin. The biological importance pulcherrimin not well understood. A previous study showed that secretion caused depletion in surroundings growth arrest on...
Aspergillus fumigatus is an opportunistic fungal pathogen that secretes array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fitness and growth within the mammalian host. Gliotoxin (GT) a SM interferes with function recruitment innate immune cells, are essential for eliminating A. during invasive infections. We identified C6 Zn cluster-type transcription factor (TF), subsequently named RglT, important oxidative stress resistance, GT...
Summary Due to an increasing demand for sustainable agricultural practices, the adoption of microbial volatile organic compounds (VOCs) as antagonists against phytopathogens has emerged eco‐friendly alternative use agrochemicals. Here, we identified three Pseudomonas strains that were able inhibit, in vitro, up 80% mycelial growth phytopathogenic fungus Thielaviopsis ethacetica , causal agent pineapple sett rot disease sugarcane. Using GC/MS, found these bacteria produced 62 different VOCs,...
The biomass-degrading fungus Trichoderma reesei has been considered a model for cellulose degradation, and it is the primary source of industrial enzymatic cocktails used in second-generation (2G) ethanol production. However, although various studies advances have conducted to understand cellulolytic system transcriptional regulation T. reesei, whole set genes related lignocellulose degradation not completely elucidated. In this study, we inferred weighted gene co-expression network analysis...
Here, we present the draft genome sequence of Komagatabaeicter rhaeticus strain AF1, which was isolated from Kombucha tea and is capable producing high levels cellulose.
Abstract One of the drawbacks during second-generation biofuel production from plant lignocellulosic biomass is accumulation glucose, preferred carbon source microorganisms, which causes repression hydrolytic enzyme secretion by industrially relevant filamentous fungi. Glucose sensing, subsequent transport and cellular signalling pathways have been barely elucidated in these organisms. This study therefore characterized transcriptional response fungus Aspergillus nidulans to presence high...
A novel ustilaginomycetous yeast isolated from the intestinal tract of an insect pest sugarcane roots in Ribeirão Preto, São Paulo State, Brazil, represents a species genus Pseudozyma based on molecular analyses D1/D2 rDNA large subunit and internal transcribed spacer (ITS1+ITS2) regions. The name brasiliensis sp. nov. is proposed for this species, with GHG001(T) ( = CBS 13268(T) UFMG-CM-Y307(T)) as type strain. P. sister vetiver, originally leaves vetiver grass Thailand. able to grow well...
Here, we present the nuclear and mitochondrial genome sequences of Pseudozyma brasiliensis sp. nov. strain GHG001. P. is closest relative vetiver. capable growing on xylose or xylan as a sole carbon source has great biotechnological potential.
Wickerhamomyces anomalus LBCM1105 is a yeast isolated from cachaça distillery fermentation vats, notable for exceptional glycerol consumption ability. We report its draft genome with 20.5x in-depth coverage and around 90% extension completeness. It harbors the sequences of proteins involved in transport metabolism.
Computational biology has gained traction as an independent scientific discipline over the last years in South America. However, there is still a growing need for bioscientists, from different backgrounds, with levels, to acquire programming skills, which could reduce time data insights and bridge communication between life scientists computer scientists. Python language extensively used bioinformatics science, particularly suitable beginners. Here, we describe conception, organization,...
Abstract PIWI-interacting RNAs (piRNAS) form an important class of non-coding that play a key role in gene expression regulation and genome integrity by silencing transposable elements. However, despite the importance piRNAs large application deep learning computational biology, there are few studies for prediction. Still, current methods focus on using advanced architectures like CNN variations. This paper presents investigation feedforward network models classification human...
Certain Aspergillus fungi cause aspergillosis, a set of diseases that typically affect immunocompromised individuals. Most cases aspergillosis are caused by fumigatus, which infects millions people annually. Some closely related so-called cryptic species, such as lentulus, can also albeit at lower frequencies, and they clinically relevant. Few antifungal drugs currently available for treating there is increasing worldwide concern about the presence drug resistance in species. Furthermore,...
Aspergillus fungi in section Fumigati include important human pathogens. Here, we sequenced the genomes of two strains hiratsukae and felis The average genome sizes are 29.5 Mb for A. 31.8 felis.
Abstract The ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for disease 2019 (COVID-19) first described from Wuhan, China. A subset of COVID-19 patients has been reported to have acquired secondary infections microbial pathogens, such as fungal opportunistic pathogens genus Aspergillus . To gain insight into associated pulmonary aspergillosis (CAPA), we analyzed genomes and characterized phenotypic profiles four CAPA isolates...
Abstract PIWI-interacting RNAs (piRNAs) are a class of noncoding whose actions range from regulating gene expression to silencing Transposable Elements, characterized for being 21 35 nucleotides long, displaying uracil bias at the 5’ end, and 2’-O-methylation 3’ end. Elements (TEs) genetic elements that move within host genomes. TE replication can promote harmful recombination events by generating breaks in DNA double strands, addition interfering with expression. Silencing these piRNAs...
Lichen-feeding termites occupy a distinctive ecological niche. This feeding behavior underscores complex interplay between the termites’ digestive abilities and biochemical properties of lichens, known for their resilience production secondary metabolites. Understanding dietary preferences mechanisms these offers insights into roles evolutionary adaptations that enable them to exploit such specialized food source. We conducted experiments with Constrictotermes cyphergaster, it different...
Abstract The rapid evolution of high-throughput technologies in biosciences has generated diverse and voluminous datasets, requiring bioscientists to develop data manipulation analysis skills. Python, known for its versatility powerful libraries, become a crucial tool managing these datasets. However, there is significant lack programming training many countries. To address this knowledge gap among scientists Brazil, the Brazilian Python Workshop Biological Data was introduced several years...
Abstract Pulcherrimin is an iron-binding reddish pigment produced by various bacterial and yeast species. In the soil bacterium Bacillus subtilis , this first synthesized intracellularly as colorless pulcherriminic acid using two molecules of tRNA-charged leucine substrate; are then secreted bind to ferric iron extracellularly form red-colored pulcherrimin. The biological importance pulcherrimin not well understood. A previous study showed that secretion caused depletion in surroundings...
Brazil would benefit from a long-term strategy for science and innovation that improves the standing of both scientists in country.