A5100375886- Pharmacological Effects of Natural Compounds
- Pharmacogenetics and Drug Metabolism
- Ginseng Biological Effects and Applications
- Fungal Biology and Applications
- Advanced Drug Delivery Systems
- Traditional Chinese Medicine Analysis
- Asymmetric Synthesis and Catalysis
- Plant-based Medicinal Research
- Bioactive Compounds and Antitumor Agents
- Asymmetric Hydrogenation and Catalysis
- Natural product bioactivities and synthesis
- Advancements in Transdermal Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Crystal structures of chemical compounds
- Analytical Chemistry and Chromatography
- Natural Antidiabetic Agents Studies
- Crystallography and molecular interactions
- Computational Drug Discovery Methods
- Vitamin K Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Immune Response and Inflammation
- Vitamin C and Antioxidants Research
- Alkaloids: synthesis and pharmacology
- Ubiquitin and proteasome pathways
- Spinal Cord Injury Research
Technological University Dublin
2019-2025
Trinity College Dublin
2012-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2022-2024
Shanghai Institute of Technology
2023-2024
Southwest Medical University
2024
Xinxiang Medical University
2023
Peking University
2023
Instytut Farmaceutyczny
2023
Zhejiang Center for Disease Control and Prevention
2023
Beijing University of Chinese Medicine
2022
LRRK2 (PARK8) is the most common genetic determinant of Parkinson's disease (PD), with dominant mutations in causing inherited PD and sequence variation at locus associated increased risk for sporadic PD. Although has been implicated diverse cellular processes encompassing almost all compartments, precise functions remain unclear. Here, we show that Drosophila homolog (Lrrk) localizes to membranes late endosomes lysosomes, physically interacts crucial mediator endosomal transport Rab7...
BACKGROUND PGC-1α can be activated by deacetylation reactions catalyzed SIRT1. Resveratrol is currently known as a potent activator of However, it unknown whether the renal-protective effect resveratrol further related to activation podocyte SIRT1/PGC-1α pathway. MATERIAL AND METHODS High glucose was used stimulate mouse podocytes. and siRNA transfection were perform co-intervention treatments. The protein mRNA expression levels SIRT1, PGC-1α, NRF1, TFAM detect immunofluorescence, Western...
Vitamins are essential organic compounds that vary widely in chemical structure and vital small quantities for numerous biochemical biological functions. They critical metabolism, growth, development maintaining overall health. categorised into two groups: hydrophilic lipophilic. Vitamin K (VK), a lipophilic vitamin, occurs naturally primary forms: phylloquinone (VK1), found green leafy vegetables algae, Menaquinones (VK2), present certain fermented animal foods formulated VK supplements....
The single enantiomer (1
Acute spinal cord injury (SCI) leads to permanent disabilities. This study evaluated the neuroprotective effect of puerarin, a natural extract, in rat model SCI.Acute SCI models were established rats using modified Allen's method. Locomotor function was BBB test. The histological changes observed by H&E staining. Neuron survival and glial cells activation immunostaining. ELISA realtime PCR used measure secretion gene expression cytokines. TUNEL staining examine cell apoptosis western...
Although inhibitors targeting CDK4/6 kinases (CDK4/6i) have shown promising clinical prospect in treating ER+/HER2- breast cancers, acquired drug resistance is frequently observed and mechanistic knowledge needed to harness their full potential. Here, we report that inhibition of promotes βTrCP1-mediated ubiquitination proteasomal degradation RB1, facilitates SP1-mediated CDK6 transcriptional activation. Intriguingly, suppression CK1ε not only efficiently prevents RB1 from degradation, but...
Though the underlying mechanism remains elusive, a close relationship between psychological stress and intestinal inflammation has been widely accepted. Such link is very important to set basis for our understanding of critical role gut-brain axis (GBA) in homeostatic processes health disease. Probiotics that could confer benefits mental through GBA are referred as “psychobiotics”. This study aimed further determine whether potential psychobiotic strain, Lactobacillus johnsonii BS15 prevent...
The indane scaffold, prevalent in bioactive natural products, underpins numerous therapeutics. Our group developed a series of 1,2-indane dimers, including PH46A (9), for inflammatory and autoimmune diseases. This study details the design, synthesis characterisation 21 compounds, 2,2-disubstituted indanones (16a-16h), indanols (17a-17h), indanes (18a-18h). These compounds were tested vitro vivo using murine dextran sulphate sodium (DSS) model bowel disease (IBD). Cytotoxicity screening THP-1...
The deoxygenative carbon-carbon bond formation from alcohols remains a formidable challenge toward cleaner coupling reactions. In this work, we first unlocked novel homocoupling upgrading mode of benzyl alcohol by...
Microglia, the resident immune cells of central nervous system (CNS), are activated by various stimuli. Resting microglia basis normal neurogenesis, while may inhibit neurogenesis through production pro-inflammatory mediators and cytokines. Recent research suggests that irradiation. This play a role in radiation-induced brain injury (RIBI). DNA double-strand breaks (DSBs), most deleterious form damage after ionizing radiation, rapidly trigger activation NF-kappaB pathway via p53-induced...
The human cytochrome P450 1A2 is an important drug metabolizing and procarcinogen activating enzyme. An experimental study found that a peripheral mutation, F186L, at ∼26 Å away from the enzyme's active site, caused significant reduction in enzymatic activity of deethylation reactions. In this paper, we explored effects mutation by carrying out molecular dynamics simulations structural analyses. We long-range F186L were through change protein flexibility collective motion main substrate...