A5100418947- Medicinal Plant Pharmacodynamics Research
- Advanced Drug Delivery Systems
- Natural product bioactivities and synthesis
- Plant-based Medicinal Research
- Fluorine in Organic Chemistry
- Sulfur-Based Synthesis Techniques
- Drug Solubulity and Delivery Systems
- Forensic Toxicology and Drug Analysis
- Traditional Chinese Medicine Analysis
- Carbohydrate Chemistry and Synthesis
- Pharmacy and Medical Practices
- Metabolomics and Mass Spectrometry Studies
- Advancements in Transdermal Drug Delivery
- Catalytic C–H Functionalization Methods
- Cytokine Signaling Pathways and Interactions
- Ginseng Biological Effects and Applications
- Microbial Metabolites in Food Biotechnology
- Traditional Chinese Medicine Studies
- Synthesis of Indole Derivatives
- Lipid metabolism and disorders
- Phytochemical compounds biological activities
- Hydrogels: synthesis, properties, applications
- Polysaccharides and Plant Cell Walls
- Bioactive Natural Diterpenoids Research
- Ginger and Zingiberaceae research
First Hospital of Qinhuangdao
2016-2025
First Affiliated Hospital of Xinjiang Medical University
2023
Xinjiang Medical University
2023
Guizhou Magic Pharmaceutical (China)
2021-2023
Jining Medical University
2021
Shanghai University of Traditional Chinese Medicine
2010-2020
Shuguang Hospital
2010-2020
Boston University
2020
Ocean University of China
2019
Okayama University
2019
Rosmarinic acid is a major phenylpropanoid isolated from Prunella vulgaris L., which composition of herbal tea for centuries in China. However, the anti-invasion activity on Ls174-T human colon carcinoma cells has not been studied. In this study, we investigated anti-metastasis functions according to wound healing assay, adhesion and Transwell assay found that rosmarinic could inhibit migration, adhesion, invasion dose-dependently. also decrease level reactive oxygen species by enhancing...
Nanoemulgels are composed of O/W nanoemulsion and hydrogels considered as ideal carriers for the transdermal drug delivery because these have high affinity to load hydrophobic drugs. The stable formulation eprinomectin (EPR) is very challenging it nature. In this work, we prepared EPR loaded nanoemulgel treatment endo- ectoparasites. surface morphology optimized formulations was characterized by scanning electron microscopy. Additionally, skin permeability irritation tests were conducted in...
A mild and convenient method for the synthesis of reverse glycosyl fluorides (RGFs) has been developed that is based on silver-promoted radical dehydroxymethylative fluorination carbohydrates. salient feature reaction furanoid pyranoid carbohydrates furnish structurally diverse RGFs bearing a wide variety functional groups in good to excellent yields. Intramolecular hydrogen atom transfer experiments revealed involves an underexploited proceeds via β-fragmentation sugar-derived primary...
This was a research study, analysed the characteristics of community-acquired pneumonia (CAP) in children and high-risk factors causing severe disease. Three hundred ninety CAP accepted therapy to First Hospital Qinhuangdao from February 2019 January 2020 were divided into spring onset group, summer autumn group winter group. The detection rates streptococcus pneumonia, haemophilus influenzae mycoplasma pneumoniae higher than other groups, while rate moraxella mucositis as groups. Univariate...
Abstract Although opioids are necessary for the treatment of acute pain, cancer and palliative care, opioid abuse is a serious threat to society. Heroin (Diacetylmorphine) most commonly abused opioid, it can have variety effects on body's tissues organs, including well-known gastrointestinal depression respiratory depression; however, there little known about diacetylmorphine cardiac damage. Here, we demonstrate that induces abnormal electrocardiographic changes in rats causes damage...
Microglia, the resident immune cells of central nervous system (CNS), are activated by various stimuli. Resting microglia basis normal neurogenesis, while may inhibit neurogenesis through production pro-inflammatory mediators and cytokines. Recent research suggests that irradiation. This play a role in radiation-induced brain injury (RIBI). DNA double-strand breaks (DSBs), most deleterious form damage after ionizing radiation, rapidly trigger activation NF-kappaB pathway via p53-induced...
Context: Accumulating evidence indicates that Herba Epimedii [Epimedii folium (Berberidaceae)] has anti-osteoporotic effect by stimulating osteoblastic bone formation and reducing osteoclastic resorption. However, the of in regulating cross-talk between osteogenic adipogenic differentiation mesenchymal stem cells (MSCs) remains unclear.Objective: The present study investigates total flavonoids (HETF) on osteogenesis adipogenesis primary MSCs.Materials methods: HETF were prepared identified...
Nickel-catalyzed decarbonylative stannylation of acyl fluorides under ligand-free conditions was disclosed. A variety aromatic are capable reacting with silylstannanes in the presence cesium fluoride. one-pot stannylation/Migita-Kosugi-Stille reaction benzoyl fluoride, giving rise to direct formation corresponding cross-coupled products, further demonstrated synthetic utility present method. This newly developed methodology a good functional-group compatibility via C-F bond cleavage and C-Sn...
The objective of this study is to evaluate the feasibility obtaining extended release tacrolimus by a novel combination lipid-based solid dispersion and matrix-type tablet techniques. Tacrolimus was prepared using glycerylbehenate (Compritol® ATO888) Pluronic F127 as carrier materials with hot-melt method, which then blended hydrogel matrix materials, such HPMC lactose, powders were directly compressed into tablets. In vitro drug tests carried out performance dispersions dissolution rate...
The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity propensity induce pathogen resistance. A promising strategy overcome these drawbacks is combine echinocandins with a molecule that improves also disrupts drug adaptation pathways. In this study, we show puupehenone (PUUP), marine-sponge-derived sesquiterpene quinone, potentiates the caspofungin (CAS) CAS-resistant...
AbstractThis study investigated the applicability of stearic acid as a co-adjuvant in cushioning agent formulated to prevent coat damage when compressing coated pellets. The co-processed and physical blended fillers were prepared by spray drying physically blending, respectively, with filler ingredients consisting acid, microcrystalline cellulose, fully gelatinized starch, corn starch. Pellets containing drug produced coating onto non-pariels layer metformin followed sustained-release layer....
Many studies had been focused on designing tacrolimus sustained release preparations based solid dispersion technique, but no one tried to employ mesoporous silica as the carrier material realize this goal. The purpose of study was develop a novel, simple and environmental friendly drug loading method with obtain sustained-release preparation. Tacrolimus firstly dissolved in molten mixed lipid composed Compritol 888 ATO Gelucire 50/13 prepare loaded lipid-based delivery systems (LBDDS), then...
It is usually a tedious task to profile the chemical composition of given herbal medicine (HM) using high performance liquid chromatography–tandem mass spectrometry (LC–MS/MS) due time-consuming sample preparation and laborious post-acquisition data processing procedures. Even worse, some labile compounds may face degradation risks when exposed organic solvents for relatively long period. As one most popular HMs, promising therapeutic benefits Epimedii Herba (Chinese name: Yinyanghuo) are...
Abstract A mild and convenient method for the synthesis of reverse glycosyl fluorides (RGFs) has been developed that is based on silver‐promoted radical dehydroxymethylative fluorination carbohydrates. salient feature reaction furanoid pyranoid carbohydrates furnish structurally diverse RGFs bearing a wide variety functional groups in good to excellent yields. Intramolecular hydrogen atom transfer experiments revealed involves an underexploited proceeds via β‐fragmentation sugar‐derived...
A series of novel alkyl amine-substituted icariside II (ICA II) derivatives were synthesized by Mannich reactions at the 6-C position (compounds 4a⁻d) and changing carbon chain length 7-OH 7a⁻h), their in vitro antitumor activity towards human breast cancer lines (MCF-7 MDA-MB-231) hepatoma cell (HepG2 HCCLM3-LUC) evaluated MTT assay. Compared with ICA II, most twelve showed good micromole level a preliminary structure-activity relationship (SAR) for anticancer was obtained. Compound 7g...
A method for the synthesis of aryl trifluoroethyl ethers from fluoroalcohols and diaryliodonium salts in presence NaH warm 1,2-dichloroethane has been developed. This transition metal free reaction is mild facile. Various functional group including electron-withdrawing electron-donating substrates were tolerated this transformation to afford products moderate high yields.
Eleven condensed tannins were isolated from the roots of Indigofera stachyodes by various column chromatography techniques including silica gel, octadecyl silica(ODS), Sephadex LH-20, and semi-preparative high performance liquid chromatography(HPLC). These compounds identified on basis physicochemical properties, nuclear magnetic resonance(NMR) mass spectrometry(MS) data as stachyotannin A(1), epicatechin-(2β→O→7,4β→8)-epiafzelechin-(4β→8)-catechin(2), cinnamtannin D1(3), B1(4),...