Paul Wan Sia Heng

ORCID: 0000-0002-8354-5764
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About
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Research Areas
  • Drug Solubulity and Delivery Systems
  • Advanced Drug Delivery Systems
  • Microencapsulation and Drying Processes
  • Granular flow and fluidized beds
  • Protein purification and stability
  • Photodynamic Therapy Research Studies
  • Advancements in Transdermal Drug Delivery
  • Analytical Methods in Pharmaceuticals
  • Powder Metallurgy Techniques and Materials
  • Inhalation and Respiratory Drug Delivery
  • Nanoplatforms for cancer theranostics
  • Injection Molding Process and Properties
  • Crystallization and Solubility Studies
  • Polysaccharides Composition and Applications
  • Aerosol Filtration and Electrostatic Precipitation
  • Hydrogels: synthesis, properties, applications
  • Advanced Cellulose Research Studies
  • Mineral Processing and Grinding
  • Porphyrin and Phthalocyanine Chemistry
  • Additive Manufacturing and 3D Printing Technologies
  • Rheology and Fluid Dynamics Studies
  • Pancreatic function and diabetes
  • Pharmaceutical studies and practices
  • Material Properties and Processing
  • Spectroscopy and Chemometric Analyses

National University of Singapore
2015-2024

Airlangga University
2024

University of Bath
1988

Milling involves the application of mechanical energy to physically break down coarse particles finer ones and is regarded as a “top–down” approach in production fine particles. Fine drug particulates are especially desired formulations designed for parenteral, respiratory transdermal use. Most drugs after crystallization may have be comminuted this physical transformation required various extents, often enhance processability or solubility with limited aqueous solubility. The mechanisms by...

10.1016/j.ajps.2014.12.006 article EN cc-by-nc-nd Asian Journal of Pharmaceutical Sciences 2015-02-17

AbstractOil-loaded microspheres were produced by spray drying emulsions consisting of fish oil and modified starch suspensions with different loadings. The emulsion stability was assessed droplet size analysis. Microspheres characterized in terms size, morphology, yield microencapsulation efficiency. It found that an increase loading resulted containing larger droplets. This corresponded mean microsphere diameters rounder microspheres. However, high loadings lower yields affected...

10.1080/02652040500100329 article EN Journal of Microencapsulation 2005-05-01

A method based on an emulsification process was developed for the production of calcium alginate microspheres. Isopropyl alcohol and acetone, which are strong dehydrating agents, were used to aid in hardening drying However, amount drug encapsulated very low. This due being soluble solvents. In absence solvents a high percentage encapsulated, this further increased by forming microspheres phase inversion. It also found that suspension particles required effective microencapsulation. The...

10.3109/02652049209021245 article EN Journal of Microencapsulation 1992-01-01

10.1016/j.cherd.2023.12.026 article EN Process Safety and Environmental Protection 2023-12-21

Hydroxypropylmethylcellulose (HPMC) is widely used for controlled-release preparations. The process of drug release controlled by matrix swelling and polymer dissolution. This study examines the mechanism behaviour HPMC in a polymer-drug directly-compressed matrix. results obtained show that which can be described first-order kinetics affected concentration viscosity grade polymer. action turn rate water uptake into matrices. An inverse relationship exists between rate. implies one factors...

10.3109/03639049309063012 article EN Drug Development and Industrial Pharmacy 1993-01-01
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