A5085588164- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Granular flow and fluidized beds
- Additive Manufacturing and 3D Printing Technologies
- Pancreatic function and diabetes
- Microencapsulation and Drying Processes
- Pharmaceutical studies and practices
- Diabetes Management and Research
- Pharmacy and Medical Practices
- Electrohydrodynamics and Fluid Dynamics
- Powder Metallurgy Techniques and Materials
- Recycling and Waste Management Techniques
- Photochemistry and Electron Transfer Studies
- Biochemical and Molecular Research
- Pharmacological Effects of Natural Compounds
- Metallurgical Processes and Thermodynamics
- Nanoparticle-Based Drug Delivery
- Aluminum Alloy Microstructure Properties
- Polymer crystallization and properties
- Hydrogels: synthesis, properties, applications
- biodegradable polymer synthesis and properties
- Surfactants and Colloidal Systems
- Crystallization and Solubility Studies
- Marine and fisheries research
- Reproductive biology and impacts on aquatic species
Gansu University of Traditional Chinese Medicine
2023
National University of Singapore
1983-1999
A method based on an emulsification process was developed for the production of calcium alginate microspheres. Isopropyl alcohol and acetone, which are strong dehydrating agents, were used to aid in hardening drying However, amount drug encapsulated very low. This due being soluble solvents. In absence solvents a high percentage encapsulated, this further increased by forming microspheres phase inversion. It also found that suspension particles required effective microencapsulation. The...
Trypsin microencapsulated in a calcium alginate matrix was lost quickly through diffusion when the microspheres were placed an aqueous medium. This problem overcome by first reacting trypsin with glutaraldehyde to form cross-linkages and then incorporating enzyme microspheres. The performance of cross-linked remained optimal at pH 8 while it found be more heat-stable highly active even 80 degrees C. Esters amides L-arginine preferentially hydrolysed indicating that cross-linking did not...
Generally discrete and spherical calcium alginate micro spheres with a high drug encapsulation efficiency were readily prepared by an emulsification process. They found to release rapidly., In the present study copolymer in form of cellulose derivatives was added sodium attempt modify profiles spheres., The effects on morphology also evaluated., increased degree agglomeration Small produced from low viscosity while larger which tended be elongated viscosity., influenced chemical nature...
AbstractAbstractChitosan microspheres were prepared using an emulsification-coacervation tcchnique. The w/o emulsion comprised a mixture of light and heavy liquid paraffins containing sodium dioctyl sulphosuccinate as the oil phase chitosan solution aqueous phase. Pentasodium tripolyphosphate was included counterion. obtained showed high degree aggregation. This markedly reduced, by incorporation magnesium stearate in disperse resultant then discrete, spherical with smooth surfaces....
Spheroids are usually produced by a multi-step extrusion-spheronization process. The single-step production of spheroids may be carried out in rotoprocessor. use feed materials powder form requires an adaptation the spheronizer machinery. This study investigates formation and growth changes spheroid moisture content agglomeration-spheronization method. There was rapid increase size formfactor values when started to grow from mix. Although there continual considerable loss with time, this did...
AbstractAn aqueous spray-drying process was used to coat theophylline particles with a cellulose polymer, sodium carboxymethylcellulose (NaCMC) or hydroxypropylmethylcellulose (HPMC). Effect of plasticizer, citric acid, studied. Strength cast films have direct relationship the dissolution T50% values respective spray-dried products. With varying plasticizer concentrations, changes in interaction between and size crystallized drug crystals, were observed HPMC films. The content also affected...
AbstractAbstractMicrospheres were formed when a solution of cellulose phthalate was extruded into 30% glacial acetic acid solution. Sulphonamides entrapped in such microspheres leached the hardening because they dissolved freely This resulted poor loading efficiency sulphonamides microspheres. When mixtures sulphaguanidine and sulphathiazole various drug ratios microencapsulated by this method, observed found to be markedly changed. attributed difference solubility two that their extent...
This study examined the effects of polyethylene glycol (PEG) binders different physical forms and from commercial sources on size distribution pellets produced. The meltable used were PEG 6000 in form flakes, coarse fine powders, melt pelletization using lactose 450 M was carried out an 8-liter high-shear mixer. Binder particle size, molecular weight, tack, viscosity determined. results showed that obtained could not be explained by binder size. related to tack molten binders. PEGs labeled...
Abstract Aqueous solutions of octyl phenoxy polyethoxy ethanol (Triton X‐114) show phase separation on standing and also in the presence corn oil. The surface tension varying concentrations upper these systems decreases markedly at lower concentrations, tending to become constant higher concentrations. activity this as observed from tension/ concentration curves may be greater, less than or about same that corresponding control which is a surfactant solution without Results study indicate...
This study examines the influence of off-bottom clearance on size and distribution pellets produced during melt pelletization at different postmelt impeller speeds binder concentrations using lactose polyethylene glycol. Melt powder 450 M in an 8-liter highshear mixer, floor which was made polytetrafluoroethylene (PTFE), carried out with glycol 3000 as meltable binder. Erosion PTFE mixer occurred time use this caused a change clearance. The findings showed that wider clearance, were much...
The pelletization process is a size enlargement whereby small particles are agglomerated by agitation, in presence of binder, to form spheroids with narrow distribution. In the melt ...
Biodegradable sustained-release microparticles containing thyroxine (T4) were developed to study the influence of hormone manipulation on broodstock reproductive performance and quality their eggs. Female tilapia (Oreochrotnis mossumbicus) injected with either T4 (2.5 μg g-1 body weight) or an equivalent amount blank microparticles. The administration generated a large increase in serum levels soon after injection [day 2); this was followed by gradual decline T4, but level remained...
Abstract An ultrafiltration‐solid membrane complexation extraction and reverse method was developed for the separation purification of liquiritigenin in licorice ultrafiltration, using ultrafiltration as precursor technology. The effects pH, time three‐phase flow rate on single‐stage rates solid were investigated, then applicability process to cascade investigated. optimum obtained with pH=6, 36 h ultrafiltration: extractant: extractant=188 : 188 94 mL min −1 , under which total transfer...
This study examines the influence of off-bottom clearance on size and distribution pellets produced during melt pelletization at different postmelt impeller speeds binder concentrations using lactose polyethylene glycol. Melt powder 450 M in an 8-liter high-shear mixer, floor which was made polytetrafluoroethylene (PTFE), carried out with glycol 3000 as meltable binder. Erosion PTFE mixer occurred time use this caused a change clearance. The findings showed that wider clearance, were much...