A5100458199- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Catalytic Alkyne Reactions
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Vanadium and Halogenation Chemistry
- Pharmacogenetics and Drug Metabolism
- Multicomponent Synthesis of Heterocycles
- Plant-based Medicinal Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Ferrocene Chemistry and Applications
- Scheduling and Optimization Algorithms
- Synthetic Organic Chemistry Methods
- Biopolymer Synthesis and Applications
- Cancer Research and Treatments
- Surface Chemistry and Catalysis
- Chemical Reactions and Isotopes
- Bacteriophages and microbial interactions
Center for Disease Control
2025
California Institute of Technology
2025
Zhejiang Cancer Hospital
2024
Chinese Academy of Sciences
2024
Nanjing Tech University
2012-2024
Southern University of Science and Technology
2020-2023
RIKEN
2019-2022
Jiangxi University of Traditional Chinese Medicine
2022
State Ethnic Affairs Commission
2021-2022
Tongji University
2022
Abstract Sterically congested C–O and C–N bonds are ubiquitous in natural products, pharmaceuticals, bioactive compounds. However, the development of a general method for efficient construction those sterically demanding covalent still remains formidable challenge. Herein, photoredox-driven ring-opening C( sp 3 )–heteroatom bond formation arylcyclopropanes is presented, which enables structurally diversified while dialkyl ether, alkyl ester, alcohol, amine, chloride/fluoride, azide also...
Abstract By resorting to the principle of remote activation, we herein demonstrate first photoredox catalyzed (3+3) dipolar cycloaddition nitrones with aryl cyclopropanes. Key fidelity reaction resides in a facile manner substrate activation by single‐electron transfer (SET) oxidation catalysis, and takes place through stepwise cascade encompassing three‐electron‐type nucleophilic substitution triggered cyclopropane ring‐opening diastereoselective 6‐endo‐ trig radical cyclization manifold....
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTCatalytic Activities of Cu(II) Complexes with Nitrogen-Chelating Bidentate Ligands in the Coupling Imidazoles Arylboronic AcidsJames P. Collman, Min Zhong, Chi Zhang, and Simona CostanzoView Author Information Department Chemistry, Stanford University, Stanford, California 94305-5080 %[email protected]Cite this: J. Org. Chem. 2001, 66, 23, 7892–7897Publication Date (Web):October 19, 2001Publication History Received15 June 2001Published online19...
Aryl cyclopropane represents an interesting class of cyclopropanes with relatively underexplored synthetic potential. Herein, we present a photoredox-catalyzed remote difunctionalization aryl cyclopropanes, which enables facile construction structurally diverse 1,3/1,5-dioxygenation products. Either alcohol or simply water is used as nucleophile. This protocol demonstrates radical cation-induced activation occurring via intramolecular electronic interaction spanning cyclopropane-embedded...
Aiming to develop efficient and general strategies for construction of complex diverse polycyclic skeletons, we have successfully developed [4+3]IMPC (intramolecular parallel cycloaddition) cyclopropane 1,1-diesters with [3]dendralenes. With a combination the subsequent [4+n] cycloadditions, trans-[5.3.0]decane skeleton its corresponding structurally variants could be constructed efficiently. This novel [4+3] cycloaddition reaction mode donor-acceptor cyclopropanes proceeds as result...
Atrial fibrillation (AF) is a common arrhythmia in clinical. Its most important pathophysiological factor atrial fibrosis. Transferrin receptor (TFRC) promotes ferroptosis by facilitating iron uptake. role AF unknown. TFRC expression Angiotensin II (Ang II)-induced mice was significantly upregulated. knockdown reduced occurrence. silence ameliorated myocardial fibrosis inhibiting TGF-β1/Smad2 pathway vivo. interference lipid oxidation product generation Ang II-induced HL-1 cardiomyocyte...
Exposure to organophosphate-based nerve agents and pesticides poses health security threats civilians, soldiers, first responders. Thus, there is a need develop effective decontamination that are nonhazardous human health. To address this, we demonstrate instantaneous hydrolysis of methyl paraoxon (Me-POX), agent simulant, can be achieved in the presence aminoguanidine imines at pH 10: ● pyridine-4-aldehyde aminoguanidine-imine (1) 2,3-butanedione (2). The Me-POX under these conditions...
A direct α-amination of β-dicarbonyl compounds has been achieved by using iodosobenzene (PhIO) as an oxidant and p-toluenesulfonamide (TsNH2) aminating reagent in the presence a catalytic amount perchlorate zinc hexahydrate. The present amination reaction proceeds quickly at rt (<30 min needed for most tested substrates) to provide corresponding α-N-tosylamido high excellent yields.
This work reports the total syntheses of Isodon diterpenes trichorabdal A and maoecrystal Z via a common bicyclo[3.2.1]octane intermediate, which chemically bridges two distinct structures through retro-aldol/aldol reaction cascade. Other synthetic features include an efficient cross-ring radical cyclization for rapid construction all carbon quaternary center commonly seen in diterpenoids, challenging Ueno-Stork on to sensitive 1,6-enone system, as well serial chemoselective functional group...
A highly efficient and mild procedure is described for the oxidation of different types alcohols using 2,2,6,6-tetramethylpiperidin-1-yloxy (TEMPO) as catalyst, iodobenzene dichloride (PhICl2) a stoichiometric oxidant, pyridine base. This also smoothly oxidizes 1,2-diols to α-hydroxy ketones or α-diketones depending upon amount used. competitive study shows that 2,2,6,6-tetramethylpiperidin-1-yloxy/iodobenzene dichloride/pyridine system aliphatic secondary are preferentially oxidized over...
One-pot synthesis of tetracyclic naphthoxazole derivatives from electron-deficient naphthoquinones and alkynes was achieved via Rh(III)-catalyzed C-H activation C(sp(3))-H bond cleavage for the first time. This approach proceeds through a tandem cascade process involving substrate tautomerization, activation, oxidative addition, cyclization, aromatization. In broad scope, simple starting materials, steric tolerance make this strategy great practicality.
A Rh-catalyzed oxidative dehydrogenative cross-coupling of 1,4-naphthquinones with alkenes was achieved by using a substituent-enabled C(sp2)–H functionalization (SEF) strategy. The method shows high functional group tolerance, broad substrate scope, and great potential for further transformations.
Abstract In contast to the general [4+2] cycloaddition reactions of alkynylcyclopropane ketones reported in literature, we report herein a Sc(OTf) 3 ‐catalyzed formal intermolecular [3+2] reaction with electron‐rich aromatic aldehydes. 2,3,3,5‐Tetrasubstituted tetrahydrofurans were obtained by this method, and tetrahydrofuran skeleton was diastereoselectively constructed 2,5‐ trans configuration. This is also quite different cis configuration usually from typical most donor–acceptor...