A5100670336- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radical Photochemical Reactions
- Fluorine in Organic Chemistry
- Sulfur-Based Synthesis Techniques
- Asymmetric Synthesis and Catalysis
- Virus-based gene therapy research
- Asymmetric Hydrogenation and Catalysis
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Inorganic Fluorides and Related Compounds
- Oxidative Organic Chemistry Reactions
- Axial and Atropisomeric Chirality Synthesis
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Research and Treatments
- Chemical Synthesis and Analysis
- CAR-T cell therapy research
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Metal-Organic Frameworks: Synthesis and Applications
- RNA Interference and Gene Delivery
Chang'an University
2025
Guangdong University of Technology
2024-2025
Anhui Agricultural University
2019-2025
Southern University of Science and Technology
2015-2024
Harbin Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
China University of Mining and Technology
2024
Advanced Research Institute
2024
North China Electric Power University
2024
Xi'an Jiaotong University
2020-2023
ConspectusAsymmetric functionalization of alkyl radicals represents a robust yet underdeveloped method for efficient construction and decoration carbon skeletons in chiral organic molecules. In this field, we have been inspired by the excellent redox, radical trapping, Lewis acidic properties copper to develop several catalytic modes asymmetric reactions involving radicals. At beginning, discovered tandem hydrotrifluoromethylation unactivated alkenes enantioselective alkoxylation remote...
The first phosphoric acid-catalyzed asymmetric direct arylative reactions of 2-naphthols with quinone derivatives have been developed, providing efficient access to a class axially chiral biaryldiols in good yields excellent enantioselectivities under mild reaction conditions. This approach is highly convergent and functional group tolerant route the rapid construction compounds from simple, readily available starting materials. stereocontrol process stems transfer stereochemical information...
A novel asymmetric radical aminotrifluoromethylation of alkenes has been developed for the first time, providing straightforward access to densely functionalized CF3-containing azaheterocycles bearing an α-tertiary stereocenter with excellent enantioselectivity. The key success is not only introduction a Cu(I)/chiral phosphoric acid dual-catalytic system but also use urea two acidic N-H as both nucleophile and directing group. utility this method illustrated by facile transformations...
An asymmetric intermolecular, three-component radical-initiated dicarbofunctionalization of 1,1-diarylalkenes with diverse carbon-centered radical precursors and electron-rich heteroaromatics by a copper(I) chiral phosphoric acid cooperative catalysis strategy has been developed, providing straightforward access to triarylmethanes bearing quaternary all-carbon stereocenters high efficiency as well excellent chemo- enantioselectivity. The key success is not only the introduction sterically...
Abstract A novel radical 1,2‐formylfunctionalization of alkenes involving 1,2(4,5)‐formyl migration triggered by addition various carbon‐ and heteroatom‐centered radicals to has been developed for the first time, thus providing straightforward access diverse β‐functionalized aldehydes with good efficiency, remarkable selectivity, excellent functional group tolerance. Analogous transformations mediated a keto‐carbonyl have also effected under similar conditions. This method was used ring...
Open AccessCCS ChemistryMINI REVIEW5 Aug 2022A Fruitful Decade of Organofluorine Chemistry: New Reagents and Reactions Feng-Ling Qing, Xin-Yuan Liu, Jun-An Ma, Qilong Shen, Qiuling Song Pingping Tang Qing *Corresponding authors: E-mail Address: [email protected] Key Laboratory Chemistry, Shanghai Institute Organic Chinese Academy Sciences, 200032 , Liu Shenzhen Grubbs Institute, Department Guangdong Provincial Catalysis, Southern University Science Technology, 518055 Ma Tianjin University,...
Abstract Shotgun metagenomics has become a pivotal technology in microbiome research, enabling in‐depth analysis of microbial communities at both the high‐resolution taxonomic and functional levels. This approach provides valuable insights diversity, interactions, their roles health disease. However, complexity data processing need for reproducibility pose significant challenges to researchers. To address these challenges, we developed EasyMetagenome, user‐friendly pipeline that supports...
Phosphine gold(I) complexes catalyzed isomerization of terminal alkenes and hydroamination unactivated under thermal microwave-assisted conditions. This is the first example use microwave radiation as a heat source for gold(I)-catalyzed organic reactions.
A method to efficiently prepare substituted 1,2-dihydroquinolines and quinolines by Au(I)-catalyzed tandem hydroamination−hydroarylation under microwave irradiation was developed. This requires short reaction time (10−70 min) has a broad substrate scope.
Purpose We previously showed that 90% (47 of 52; 95% CI, 0.79 to 0.96) lung adenocarcinomas from East Asian never-smokers harbored well-known oncogenic mutations in just four genes: EGFR, HER2, ALK, and KRAS. Here, we sought extend these findings more samples identify driver alterations tumors negative for mutations. Experimental Design have collected analyzed 202 resected never smokers seen at Fudan University Shanghai Cancer Center. Since were mutually exclusive the first 52 examined,...
A method for the synthesis of enantiomerically enriched secondary amines with excellent ee values through tandem intermolecular hydroamination/transfer hydrogenation alkynes using a "gold(I) complex−chiral Brønsted acid" protocol is developed. The catalysis works wide variety aryl, alkenyl, and aliphatic as well anilines different electronic properties.
Abstract An asymmetric unactivated alkene/CH bond difunctionalization reaction for the concomitant construction of CCF 3 and CO bonds was realized by using a Cu/Brønsted acid cooperative catalytic system, thus providing facile access to valuable chiral CF ‐containing N,O‐aminals with excellent regio‐, chemo‐, enantioselectivity. Mechanistic studies revealed that this may proceed an unprecedented 1,5‐hydride shift involving activation alkenes radical trifluoromethylation initiate...
The first example of a metal-free direct carbotrifluoromethylation alkenes using inexpensive TMSCF3 as the CF3 source is described. methodology not only exhibits high chemoselectivity for this transformation but also expands substrate scope that difficult to access by known transition-metal-catalyzed methods.
Abstract Medium-sized and medium-bridged rings are attractive structural motifs in natural products therapeutic agents. Due to the unfavourable entropic and/or enthalpic factors with these ring systems, their efficient construction remains a formidable challenge. To address this problem, we herein disclose radical-based approach for diversity-oriented synthesis of various benzannulated carbon- heteroatom-containing 8–11(14)-membered ketone libraries. This strategy involves 1,4- or 1,5-aryl...
An organocatalytic asymmetric trifluoromethylthiolation reaction via in situ generation of active electrophilic trifluoromethylthio species involving trichloroisocyanuric acid and AgSCF3 as a practical easily handled SCF3 source for CSP3–SCF3 bond formation was developed. Reactions with this one-pot version strategy occurred good yields excellent stereoselectivities to access enantiopure oxindoles bearing SCF3-substituted quaternary chiral center. The straightforward process described here...
Although great success has been achieved in asymmetric fluoroalkylation reactions via nucleophilic or electrophilic processes, the development of radical versions this type remains a formidable challenge because involvement highly reactive species. Here we report catalytic aminoperfluoroalkylation and aminodifluoromethylation alkenes with commercially available fluoroalkylsulfonyl chlorides as sources, providing versatile platform to access four types enantioenriched α-tertiary pyrrolidines...
Bicycles built in water: The AuI-catalyzed tandem cyclization of 1-amino-4-alkynes with alkynes water offers a simple and efficient method for the synthesis diversely substituted pyrrolo[1,2-a]quinolines good to excellent product yields regio- chemoselectivities (see scheme). Supporting information this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z800160_s.pdf or from author. Please note: publisher not responsible content functionality any supporting...