A5063084382- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Organoboron and organosilicon chemistry
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
Southern University of Science and Technology
2019-2024
Advanced Research Institute
2024
Harbin Institute of Technology
2024
Abstract We describe a photoinduced copper‐catalyzed asymmetric radical decarboxylative alkynylation of bench‐stable N‐hydroxyphthalimide(NHP)‐type esters racemic alkyl carboxylic acids with terminal alkynes, which provides flexible platform for the construction chiral C(sp 3 )−C(sp) bonds. Critical to success this process are not only use copper catalyst as dual photo‐ and cross‐coupling but also tuning NHP‐type inhibit facile homodimerization alkyne, respectively. Owing stable easily...
Abstract Transition metal-catalyzed enantioselective Sonogashira-type oxidative C( sp 3 )—C( ) coupling of unactivated )−H bonds with terminal alkynes has remained a prominent challenge. The difficulties mainly stem from the regiocontrol in )—H bond functionalization and inhibition readily occurring Glaser homocoupling alkynes. Here, we report copper/chiral cinchona alkaloid-based N,N,P -ligand catalyst for asymmetric cross-coupling highly regio-, chemo-, manner. use N -fluoroamide as mild...
The enantioconvergent C(sp3)-N cross-coupling of racemic alkyl halides with (hetero)aromatic amines represents an ideal means to afford enantioenriched N-alkyl yet has remained unexplored due the catalyst poisoning specifically for strong-coordinating heteroaromatic amines. Here, we demonstrate a copper-catalyzed radical activated under ambient conditions. key success is judicious selection appropriate multidentate anionic ligands through readily fine-tuning both electronic and steric...
The 3d transition metal-catalyzed enantioconvergent radical cross-coupling provides a powerful tool for chiral molecule synthesis. In the classic mechanism, bond formation relies on interaction between nucleophile-sequestered metal complexes and radicals, limiting nucleophile scope to sterically uncongested ones. coupling of congested nucleophiles poses significant challenge due difficulties in transmetalation, restricting reaction generality. Here, we describe probable outer-sphere...
Abstract We describe a photoinduced copper‐catalyzed asymmetric radical decarboxylative alkynylation of bench‐stable N‐hydroxyphthalimide(NHP)‐type esters racemic alkyl carboxylic acids with terminal alkynes, which provides flexible platform for the construction chiral C(sp 3 )−C(sp) bonds. Critical to success this process are not only use copper catalyst as dual photo‐ and cross‐coupling but also tuning NHP‐type inhibit facile homodimerization alkyne, respectively. Owing stable easily...