A5066061437- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Lung Cancer Diagnosis and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Anorectal Disease Treatments and Outcomes
- Cancer Immunotherapy and Biomarkers
- Medical Image Segmentation Techniques
- Adipose Tissue and Metabolism
- Gastric Cancer Management and Outcomes
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- COVID-19 diagnosis using AI
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Bariatric Surgery and Outcomes
- Genetic factors in colorectal cancer
- Spine and Intervertebral Disc Pathology
- Body Contouring and Surgery
- Circadian rhythm and melatonin
- MicroRNA in disease regulation
- Cardiovascular Health and Disease Prevention
- Cervical and Thoracic Myelopathy
- Obesity and Health Practices
Peking University Shougang Hospital
2021-2025
Wuhu Fourth People Hospital
2025
East China Normal University
2025
Capital Medical University
2013-2024
Beijing Chao-Yang Hospital
2013-2024
Jinan City People's Hospital
2024
Shandong First Medical University
2024
Leiden University Medical Center
2017-2023
Second Hospital of Anhui Medical University
2023
Anhui Medical University
2023
During normal development or during disease, animal cells experience hypoxic (low oxygen) conditions, and the hypoxia-inducible factor (HIF) transcription factors implement most of critical changes in gene expression that enable animals to adapt this stress. Here, we examine roles HIF-1 post-mitotic aging. We examined effects over-expression hif-1 loss-of-function mutations on longevity C. elegans, a powerful genetic system which adult somatic are post-mitotic. constructed transgenic lines...
Recent innovations in light sheet microscopy, paired with developments tissue clearing techniques, enable the 3D imaging of large mammalian tissues cellular resolution. Combined progress large-scale data analysis, driven by deep learning, these empower researchers to rapidly investigate morphological and functional properties diverse biological samples. Segmentation, a crucial preliminary step analysis process, can be automated using domain-specific learning models expert-level performance....
Despite the great impact on long-term survival of some cancer patients, immune checkpoint blockade (ICB) therapy is limited by its low response rates for most cancers. There a pressing need novel combination immunotherapies that overcome resistance to current ICB therapies. Cytokines play pivotal role in tumor immunotherapy helping initiating and driving antitumor responses. Here, we demonstrated that, besides conventional CD4+ CD8+ T cells, IL36 surprisingly increased number...
Atrial fibrillation (AF) is a common arrhythmia in clinical. Its most important pathophysiological factor atrial fibrosis. Transferrin receptor (TFRC) promotes ferroptosis by facilitating iron uptake. role AF unknown. TFRC expression Angiotensin II (Ang II)-induced mice was significantly upregulated. knockdown reduced occurrence. silence ameliorated myocardial fibrosis inhibiting TGF-β1/Smad2 pathway vivo. interference lipid oxidation product generation Ang II-induced HL-1 cardiomyocyte...
Abstract Checkpoint blockade therapy triggers tumor-specific immune responses in a variety of cancer types. We presumed that rectal patients could have become sensitive to immunotherapy after receiving neoadjuvant chemoradiotherapy (nCRT). In this study, we report alternation post-nCRT compared with pretreatment conditions from gene-expression omnibus (GEO) data. Whole-exome sequencing 14 locally advanced (LARC) patient samples showed nCRT induced new mutations the paired biopsies, evidenced...
Background: Colorectal cancer (CRC) imposes significant health burden and is increasing in incidence.NGPTL4 has been implicated the development of CRC.The present study aimed to investigate molecular mechanisms by which ANGPTL4 expression might regulate epithelial-mesenchymal transition (EMT) tumor microenvironment CRC.Methods: CRC para-carcinoma tissues were collected from 67 patients.ANGPTL4 levels DNA methylation promoter region determined.Next, migration invasion capacities cells...
The exonization of an Alu‐like element into a coding sequence is unique to primates and this phenomenon distinguishes our genome from other mammals. Here, we report the presence special splicing variant proapoptotic protein Bcl‐rambo in human lymph node, designated as beta. This contains 98 bp which acts exon. There exists in‐frame stop codon within inserted cassette, resulting generation premature 104 amino acid residues. Unlike Bcl‐rambo, beta lacking BH1, BH2 BH3 motifs becomes BH4‐only...
Accurate lung vessel segmentation is an important operation for CT analysis. Filters that are based on analyzing the eigenvalues of Hessian matrix popular pulmonary enhancement. However, due to their low response at bifurcations and boundaries, extracting vessels by thresholding vesselness not sufficiently accurate. Some methods turn graph-cuts more accurate segmentation, as it incorporates neighbourhood information. In this work, we propose a new cost function combining appearance shape,...
Vascular remodeling is a significant pathological feature of various pulmonary diseases, which may be assessed by quantitative computed tomography (CT) imaging. The purpose this study was therefore to develop and validate an automatic method for quantifying vascular morphology in CT images.The proposed consists vessel extraction quantification. For extracting vessels, graph-cuts-based considers appearance (CT intensity) shape (vesselness from Hessian-based filter) features, incorporates...
To analyze locally advanced rectal cancer (LARC) patients and tumor characteristics during the period of total neoadjuvant therapy (TNT) explore risk factors that may predict poor regression in response to TNT.The data 120 LARC who received TNT from December 2016 September 2019 our hospital were retrospectively analyzed. The clinicopathological with different responses compared. Then we divided into two groups according carcinoembryonic antigen (CEA) clearance pattern after chemoradiation...
The shape and distribution of vascular lesions in pulmonary embolism (PE) chronic thromboembolic hypertension (CTEPH) are different. We investigated whether automated quantification morphology densitometry arteries veins imaged by computed tomographic angiography (CTPA) could distinguish PE from CTEPH. analyzed CTPA images a cohort 16 patients, 6 CTEPH 15 controls. Pulmonary vessels were extracted with graph-cut method, separated into using deep-learning classification. Vascular was...
In this study, a technique for computer-aided diagnosis (CAD) systems to detect lung nodules in X-ray pulmonary computed tomography (CT) images is proposed. The adaptive border marching algorithm was implemented volume segmentation. Region growing and rule based method were used the candidates. Then, we extracted total of 11 features, including intensity features geometry these fuzzy min-max neural network classifier with compensatory neurons (FMCN) advanced by K-means clustering,...
Balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic hypertension (CTEPH) can have variable outcomes. To gain more insight into this variation, we designed a method for visualizing and quantifying changes perfusion by automatically comparing computed tomography (CT) angiography before after BPA treatment. We validated these quantifications of against hemodynamic measured right-sided heart catheterization.We studied 14 consecutive CTEPH (12 women; age, 70.5 ±...
Introduction. Tension-free hernia repair has been regarded as a gold standard treatment for selected inguinal hernias, but the use of prosthetic mesh in acute incarcerated hernias is controversial. Our study focused on evaluating safety and efficacy emergency cases. Methods. Patients with who underwent during 2009 to 2014 at our department were included. Patient characteristics, operative approaches results, complications retrospectively analyzed. Results. A total 167 patients included...
Foam cells are characteristic pathologic of atherosclerosis (AS), they lipid-loaded macrophages present on atherosclerotic lesions. A large number studies has shown that the pathogenesis AS is result interactions between lipid metabolism disorders and chronic inflammatory responses in body. Albiflorin can inhibit response it a therapeutic effect certain diseases.In this study, human acute monocytic leukemia cell line (THP-1)-derived foam model was established via oxidized low-density...
To investigate the value of transanal multipoint full-layer puncture biopsy (TMFP) in predicting pathological complete response (pCR) after neoadjuvant radiotherapy and chemotherapy (nCRT) patients with locally advanced rectal cancer (LARC) to establish a predictive model for providing clinical guidance regarding treatment LARC.