A5008227472- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Metabolomics and Mass Spectrometry Studies
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Ginseng Biological Effects and Applications
- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Radiomics and Machine Learning in Medical Imaging
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Renal cell carcinoma treatment
Peking University
2020-2023
Tsinghua University
2018-2023
Center for Life Sciences
2018-2023
King Center
2022
Background Distant metastasis is the major cause of mortality in patients with locally advanced rectal cancer (LARC) following neoadjuvant chemoradiotherapy. Local radiotherapy can trigger an abscopal response to metastatic tumor cells. However, effect a rare event. CD4+ regulatory T (Treg) cell highly immune-suppressive subset which impedes immune surveillance against cancer, prevents development effective antitumor immunity and promotes progression. We assume that exploitation...
Chemo-/radiotherapy resistance is the main cause accounting for most treatment failure in colorectal cancer (CRC). Tumor-initiating cells (TICs) are culprit leading to CRC chemo-/radiotherapy resistance. The underlying regulation mechanism of TICs remains unclear. Here we discovered that miR-15b expression positively correlated with therapeutic outcome CRC. Expression pretreatment biopsy tissue samples predicted tumor regression grade (TRG) rectal patients after receiving neoadjuvant...
As a kind of prevalent malignancy globally, hepatocellular carcinoma (HCC) is characterized by significant morbidity and mortality due to the difficulties in early diagnosis limited treatment options. Circular RNAs (circRNAs) are type circular single-stranded RNA molecule formed back-splicing 5' end 3' linear RNA, possessing multiple biological functions. In recent years, numerous reports have demonstrated that circRNAs potential biomarkers therapeutic targets for HCC. this study, we found...
Abstract Checkpoint blockade therapy triggers tumor-specific immune responses in a variety of cancer types. We presumed that rectal patients could have become sensitive to immunotherapy after receiving neoadjuvant chemoradiotherapy (nCRT). In this study, we report alternation post-nCRT compared with pretreatment conditions from gene-expression omnibus (GEO) data. Whole-exome sequencing 14 locally advanced (LARC) patient samples showed nCRT induced new mutations the paired biopsies, evidenced...
Preoperative neoadjuvant chemoradiation (nCRT) has been the standard treatment for locally advanced rectal cancer. Serum biomarkers to stratify patients with respect prognosis and response nCRT are needed due diverse therapy.Thirteen paired pre- post-nCRT sera from cancer were analyzed by isobaric tags relative absolute quantitation (iTRAQ) method. Twenty-five proteins selected validation parallel reaction monitoring (PRM) in ninety-one patients.Totally, 310 identified quantified samples....
Type 2 diabetes mellitus (T2DM) is an independent risk factor for colorectal cancer (CRC), and the patients with CRC T2DM have worse survival. The human gut microbiota (GM) linked to development of T2DM, respectively. However, GM characteristics in remain unclear.We performed fecal metagenomic targeted metabolomics studies on 36 samples from (DCRC group, n = 12), without (CRC healthy controls (Health 12). We analyzed microbiomes, characterized composition function based metagenomics DCRC...
Objective: To understand the treatment status and effects on colorectal cancer (CRC) patients in China during COVID-19 pandemic, provide evidence for decision-making health-care workers. Methods: The method of cross-sectional study was applied. A questionnaire survey CRC carried out. Their basic information were collected associated treatment, nursing, state psychology needs social support analyzed. Results: Of 1147 participants study, 635 (55.4%) male 512 (44.6%) female with mean age...
Objective: To analyze the clinicopathological features of type 2 diabetes mellitus complicated with colorectal cancer (DCRC). Methods: A case-control study was conducted. Inclusion criteria: (1) hospitalized patients receiving fibrocolonoscopy; (2) adenocarcinoma and mucinous diagnosed by pathology; (3) preoperative cTNM clinical staging; (4) undergoing surgical treatment; (5) postoperative pTNM (6) no smoking or drinking habits. Exclusion familial adenomatous polyposis (FAP); Lynch...