A5100341902- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Surgery and Rehabilitation
- Wound Healing and Treatments
- Reconstructive Facial Surgery Techniques
- Bone fractures and treatments
- Surgical Sutures and Adhesives
- Elbow and Forearm Trauma Treatment
- Hip and Femur Fractures
- Periodontal Regeneration and Treatments
- Venous Thromboembolism Diagnosis and Management
- Congenital limb and hand anomalies
- Diabetic Foot Ulcer Assessment and Management
- Corneal Surgery and Treatments
- Shoulder and Clavicle Injuries
- Trauma Management and Diagnosis
- Dupuytren's Contracture and Treatments
- Organ and Tissue Transplantation Research
- Protein Kinase Regulation and GTPase Signaling
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Nail Diseases and Treatments
- Burn Injury Management and Outcomes
- Autophagy in Disease and Therapy
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal synovial abnormalities and treatments
Weifang People's Hospital
2025
Xian Yang Central Hospital
2025
Southern University of Science and Technology
2024-2025
Jinan University
2025
Harry Perkins Institute of Medical Research
2015-2025
The University of Western Australia
2015-2025
State Key Laboratory of Electrical Insulation and Power Equipment
2024
Xi'an Jiaotong University
2024
China University of Geosciences (Beijing)
2024
Wenzhou Medical University
2014-2023
Esophageal cancer (EC) ranks eighth among cancers in cancer-related deaths globally, and ~44% of new cases occur China. We sought to describe the clinical characteristics treatment landscape EC China before approval immunotherapy 2020. CHANNEL was a large, retrospective study using patient-level data from 14 hospitals/cancer centers across China, including adults initiating therapy for newly diagnosed (January December 2018). Demographics, clinicopathologic characteristics, patterns over 6...
Highlights•LIGHT targeting into tumors normalizes the vasculature and improves therapy•Vascular integrity is restored by inducing pericyte contractility•LIGHT triggers a peri-vascular signaling cascade involving macrophages TGF-β•LIGHT-RGR effects are Rho kinase-dependent restricted to vascular bedSummaryNormalization of tumor an emerging concept shown improve anti-cancer therapy. However, there currently no clinical interventions that effect long-lasting normalization. Here, we have...
Ischaemia-reperfusion (I/R) injury is a major contributor to skin flap necrosis, which presents challenge in achieving satisfactory therapeutic outcomes. Previous studies showed that cathelicidin-BF (BF-30) protects tissues from I/R injury. In this investigation, BF-30 was synthesized and its role mechanism promoting survival of I/R-injured flaps explored.
Abstract The intratumoral immune milieu is crucial for the success of anti-cancer immunotherapy. We show here that stromal modulation by tubulin-binding drugs combretastatin A4 (CA-4) and eribulin improved tumor perfusion anti-tumor immunity. This was achieved reverting highly proliferative, angiogenic pericytes into a quiescent, contractile state which durably normalized vascular bed reduced hypoxia in mouse models pancreatic neuroendocrine cancer, breast cancer melanoma. event pericyte...
As a kind of prevalent malignancy globally, hepatocellular carcinoma (HCC) is characterized by significant morbidity and mortality due to the difficulties in early diagnosis limited treatment options. Circular RNAs (circRNAs) are type circular single-stranded RNA molecule formed back-splicing 5' end 3' linear RNA, possessing multiple biological functions. In recent years, numerous reports have demonstrated that circRNAs potential biomarkers therapeutic targets for HCC. this study, we found...
Degloving injuries are severe and frequently underestimated lesions. Lower extremities the most commonly affected limbs. This injury is associated with a high morbidity mortality if mismanaged. The treatment of such patients still varies, clinical indicators for its prognosis scarce, some technical protocols also controversial.Between August 2002 July 2011, 102 skin avulsion 129 lower were treated immediate full-thickness graft following protocol radical debridement. grafts processed sharp...
Skin flap transplantation is a common wound repair method in orthopedic surgery, but skin necrosis remains problematic. Memantine, an excitatory amino acid receptor antagonist, currently used the treatment of moderate to severe Alzheimer's disease, due its ability promote angiogenesis and reduce oxidative stress. This study investigated effect memantine on survival random flaps Sprague-Dawley (SD) rats. Thirty six male SD rats were divided into control, high-dose (20 mg/kg per day), low-dose...
Random skin flaps are often used in reconstruction operations. However, flap necrosis is still a common postoperative complication. Here, we investigated whether berberine (C20 H19 NO5 , BBR), drug with antioxidant activity, improves the survival rate of random flaps. Fifty-four rats were divided into three groups: control, BBR and + L -NAME groups (L -NAME, -NG -Nitro-arginine methyl ester). The condition percentage area evaluated on seventh day after surgery. After animals sacrificed,...
Reconstruction of chronic lower extremity wounds remains challenging. These are mainly associated with diabetes mellitus, infections, and osteomyelitis. Although several reconstructive techniques available, the peroneal artery perforator flap has unique advantages. In this study, we discuss our experiences flaps in 55 patients who had suffered from limb wounds. The size defect, comorbidities, etiology, size, complications were recorded analyzed based on a retrospective chart review. All...
Abstract Random‐pattern skin flaps are widely applied to rebuild and restore soft‐tissue damage in reconstructive surgery; however, ischemia subsequent ischemia‐reperfusion injury lead flap necrosis major complications. Exenatide, a glucagon‐like peptide‐1 analog, exerts therapeutic benefits for diabetic wounds, cardiac injury, nonalcoholic fatty liver disease. Furthermore, Exenatide is known activator of autophagy, which complex process subcellular degradation that may enhance the viability...
Degloving injuries of the foot with involvement heel and sole occur relatively rarely but pose an extreme challenge to reconstructive surgeon due unique anatomy foot. Very limited studies are available regarding outcomes reattachment degloved skin as a full-thickness graft.Twenty-one patients, including eight children thirteen adults, were treated for degloving injury immediate defatted graft from September 2002 January 2010. After its original anatomical site, was further secured multiple...
Abstract In this retrospective study, the survival rates of fingertip replantation with and without vein grafting were evaluated along their postoperative functional cosmetic results. One hundred twenty‐one‐fingertip amputations performed in 103 patients between September 2002 July 2007. Thirty‐four amputated fingertips replanted grafting, while 87 for arterial and/or venous repairs. The overall replantations 90% (78/87) 85% (29/34), respectively. 88% (36/41) repair, 93% (25/27) 89% (17/19)...
Background The purpose of this study was to compare the reconstructive outcomes soft-tissue defects around foot and ankle with local or free flaps attempt provide an optimal strategy for these patients in comparison conventional guidelines. Methods A retrospective review all continuous reconstruction using different from 2010 2018 performed. Based on flap types, were divided into 2 groups: group group. Outcomes assessed according survival rate, recipient complications, aesthetic outcomes,...
Random skin flaps are commonly used for wound repair and reconstruction. Electroacupuncture at The Zusanli point could enhance microcirculation blood perfusion in random flaps.To determine whether electroacupuncture can improve the survival of a rat model.Thirty-six male Sprague Dawley rats were randomly divided into 3 groups: control group (no electroacupuncture), Group A (electroacupuncture nonacupoint near point), B point). McFarlane established. On postoperative Day 2, malondialdehyde...
The perforator flaps are characterized by their thinness and the adjustable length of vascular pedicle. purpose this investigation is to refine anatomy perforators in middorsoradial forearm present our clinical experience using free flap reconstruction finger defects. Anatomic study was conducted on 46 cadaver forearms. It noted that a consistently observed midforearm exhibiting 4 patterns, which dorsoradial with 37 cases (80.4%) originating from interosseous artery system (patterns 1-3) 9...