Osteoarthritis (OA), an age-related degenerative disease, is characterized by progressive degradation of the articular cartilage. There increasing evidence that nobiletin (NOB) exerts special biological functions in a variety diseases. However, whether it protects against OA remains unknown. In this study, we investigated anti-inflammatory and chondroprotective effects NOB on IL-1β-induced human chondrocytes surgical DMM mice models. vitro, treatment completely suppressed overproduction...

Open reduction and internal fixation of pelvic fractures could restore the stability ring, but there were several problems. Minimally invasive closed cannulated screw treatment has lots advantages. However, how to insert safely effectively achieve a reliable still hard for orthopedist. Our aim was explore significance 3D printing technology as new method minimally unstable fracture. One hundred thirty-seven patients with from 2014 2016 retrospectively analyzed. Based on usage preoperative...

Aim: Acromioclavicular joint dislocation is one of the most common shoulder problems and may lead to instability or degenerative changes. The aim this study was compare clinical outcomes Tight Rope system clavicular hook plate for Rockwood type III acromioclavicular in adults. Materials Methods: This a prospective, randomized hospital setting. From January 2012 December 2014, 69 patients with injury were reviewed. Patients randomly divided into two groups: Group A treated using TightRope B...

Osteoarthritis (OA) is a degenerative joint disease characterized by the degradation and inflammation of cartilage. Phloretin, type dihydrochalcone mainly found in apples apple-derived products, has been reported to possess various potent biological effects such as antioxidant, anticancer, anti-inflammatory, immunomodulatory. However, anti-inflammatory phloretin on OA have not reported. This study was aimed at assessing human chondrocytes. Human chondrocytes were pretreated with (10, 30, 100...

Hip fracture is a severe and common injury that occurs predominantly in the elderly. Blood loss perioperative period associated with greater risk of dying anaemic patients. The aim study was to explore best way treat stable intertrochanteric fractures, taking hidden blood into account. This prospective, randomised blinded included patients aged over 65 years fractures (Evans grades I II). were allocated one two groups treated via extramedullary or intramedullary fixation. Patient data...

Femoral head fractures are uncommon injuries. Open reduction and internal fixation (ORIF) of femoral fracture is the preferred treatment for most patients. There several surgical approaches treatments this difficult fracture. However, optimal approach remains controversial. Meanwhile, operation complications numerous. We prospectively reviewed patients with managed surgically through 3D printing-based Ganz to define a better least morbidity.Between 2012 2017, total 17 were included in study....

Object: A novel technique, percutaneous elastic stable intramedullary nail fixation (ESIN), proposed by our team for the treatment of anterior pelvic ring injury. Finite element analysis and retrospective case-control study were used to compare biomechanical properties clinical outcomes between ESIN other techniques. Methods: Four groups finite models injury simulated, including (model A), retrograde transpubic screw (RTSF, model B), subcutaneous internal fixator C), external D), a vertical...

Abstract Background Implant choice for the fixation of femoral neck fracture is one most important management controversies. This study aims to evaluate and compare short-term outcomes associated with use Femoral Neck System (FNS), Multiple Cancellous Screws (MCS), Dynamic Hip (DHS) in treating fractures a young patient population. Methods From June 2018 2021, total 120 surgeries primary were retrospectively analyzed. review encompassed demographic details patients mechanisms behind...

The management of displaced intra-articular calcaneal fractures (DIACFs) remains challenging and controversial. A prospective randomized controlled trial was conducted to compare percutaneous reduction, cannulated screw fixation calcium sulfate cement (PR+CSC) grafting with minimally invasive sinus tarsi approach plate (MISTA) for treatment DIACFs. Ultimately, 80 patients a DIACFs were randomly allocated receive either PR+CSC (N = 42) or MISTA 38). Functional outcomes evaluated using the...

Use of a random skin flap is common for repairing wounds and reconstruction. Lidocaine traditional local anesthetic that blocks sodium channels has positive effects on ischemia-reperfusion injury.To investigate the lidocaine survival in rats.McFarlane flaps were established 20 rats divided into 2 groups. was injected group, same concentration saline control group. The area measured Day 7. Levels inflammation evaluated by hematoxylin eosin (H&E)-stained slices, superoxide dismutase...

Abstract Background Acute ankle injuries are commonly seen in emergency rooms, with significant social impact and potentially devastating consequences. While several clinical practice guidelines (CPGs) related to have been developed by various organizations, there is a lack of critical appraisal them. The purpose this systematic review identify critically appraise evidence-based (EB-CPGs) acute adults. Method We conducted searches the Cochrane Library, MEDLINE, EMBASE databases, WHO,...

<b>Background</b> Huangqi (<i>Radix astragali</i>) is a traditional Chinese drug, designed to "buqi," which means invigorating vital energy, widely used in clinical settings. We investigated the effect of injection on survival random skin flaps. <b>Methods</b> McFarlane flaps were established 60 rats divided into two groups. Postoperative celiac injections given both groups for 7 days. was injected test group, and saline controls. On day 7, tissues stained with hematoxylin eosin,...

Background . A Shuxuetong injection is traditionally used in Chinese medicine to treat “blood stasis and stagnation” (yu xue yu zhi). We investigated the effect of such on survival random skin flaps. Methods McFarlane flaps were established 60 rats divided into two groups. Postoperative celiac injections given both groups for 7 days. was injected test group, saline controls. On day 7, tissues stained with H&amp;E (hematoxylin-eosin) stain, immunohistochemically evaluated, expression levels...

BACKGROUND:In this study we prepared liposome microbubbles loading resveratrol (LMLR) and evaluated its therapeutic effect on injury of gastrocnemius muscle in rats. MATERIAL AND METHODS:LMLR was characterized by particle size, potential, microscopy, a rat model acute blunt established. After treatments with or LMLR, the effects were hematoxylin-eosin (HE) staining. The expression MHCIIB vimentin mRNA level measured real-time PCR. desmin collagen I protein assessed immunohistochemistry....