A5033639682- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- Shoulder Injury and Treatment
- Lung Cancer Research Studies
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Trauma Management and Diagnosis
- Shoulder and Clavicle Injuries
- Cerebrovascular and Carotid Artery Diseases
- Hip and Femur Fractures
- Spinal Fractures and Fixation Techniques
- Acute Myocardial Infarction Research
- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiac pacing and defibrillation studies
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Cervical and Thoracic Myelopathy
University College London
2024
Hangzhou First People's Hospital
2021-2024
Johns Hopkins University
2024
Albert Einstein College of Medicine
2024
Massachusetts General Hospital
2024
Harvard University
2024
Zunyi Medical University
2019-2024
Rutgers, The State University of New Jersey
2024
Southern Medical University Shenzhen Hospital
2021-2024
Second Military Medical University
2008-2024
Background Cancer-associated fibroblasts (CAFs) contribute to the progression and treatment of breast cancer (BRCA); however, risk signatures molecular targets based on CAFs are limited. This study aims identify novel CAF-related biomarkers develop a signature for predicting prognosis therapeutic response patients with BRCA. Methods genes (CAFRGs) these were comprehensively analyzed using publicly available bulk single-cell transcriptomic datasets. Modular identified from sequencing data...
It is currently debated whether AP1 or Sp1 the factor that mediates transforming growth beta1 (TGF-beta) stimulation of human alpha2(I) collagen (COL1A2) gene by binding to an upstream promoter element (TbRE). The present study was designed resolve this controversy correlating expression COL1A2, AP1, and in same cell line under different experimental conditions. results strongly indicate required for immediate early response COL1A2 TGF-beta not. inhibitor mithramycin blocked mRNA...
Summary. In acute myeloid leukaemia (AML), cell kinetic quiescence has been postulated to contribute drug resistance. As the anti‐apoptotic genes Bcl‐2 and Bcl‐X L have implicated in cycle regulation, we investigated expression of these non‐proliferating (Q) proliferating (P) AML normal CD34 + progenitor cells. Using reverse transcription polymerase chain reaction, were overexpressed Q versus P cells, whereas no difference S Bax was found. Furthermore, /X but not Bcl‐2/Bax ratio higher...
Aims In patients submitted to coronary angiography, fractional flow reserve (FFR) assessment by a pressure wire can be used guide the decision for revascularization. Routine application of FFR and 1-year outcome are poorly documented. The aim this study was report 4-year single-centre experience where use making in equivocal lesions is encouraged. Methods results A prospective registry designed collect clinical angiographic characteristics, as well follow-up all assessment. decisional...
Aims Circumferential pulmonary vein isolation (CPVI) has been reported to account for 30% of atrial fibrillation (AF) recurrence after initial ablation, and (PV) re-connection accounts about 80% AF recurrence. There is no information in the literature whether early identification treatment acute PV conduction recovery during ablation an impact on subsequent clinical results. The objective investigate prevalence observation time paroxysmal AF, evaluate re-isolation
Increasing evidence has shown that UBE2T plays an important role in genomic integrity and carcinogenesis; however, its nasopharyngeal carcinoma (NPC) not been investigated. Here, we evaluated the clinicopathological significance of NPC underlying mechanisms. Using immunohistochemical analysis expression samples, demonstrated is highly expressed tissues, which correlated with T/M classification, skull invasion, poor prognosis. The vitro assay showed overexpression promoted proliferation,...
// Bo Tang 1,2,* , Fang 3,* Li Shengguang Yuan 1,2 Qing Xu Stephen Tomlinson 4 Junfei Jin 2 Wei Hu 5 and Songqing He 1 Department of Hepatobiliary Surgery, Affiliated Hospital Guilin Medical University, Guilin, Guangxi, People's Republic China Guangxi Key Laboratory Molecular Medicine in Liver Injury Repair, 3 Pathology, Microbiology Immunology, Darby Children's Research Institute, University South Carolina, Charleston, USA Medicine, The First Jilin Changchun, Jilin, * These authors have...
Background Mucosal-associated invariant T (MAIT) cells are considered to participate of the host immune response against acute severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, single-cell transcriptomic profiling MAIT in patients with COVID-19 remains unexplored. Methods We performed RNA sequencing analyses on peripheral from 13 and 5 healthy donors. The transcriptional profiles cells, together assembled T-cell receptor sequences, were analyzed. Flow cytometry...
Abstract This study intended to evaluate the diagnostic accuracy of prostate imaging reporting and data system (PI-RADS) prostate-specific antigen density (PSAD) for clinically significant cancer (csPCa) with PSA levels 4–10 ng/ml. Between July 2018 June 2022, a total 453 patients ng/ml were retrospectively included, which randomly assigned training group (323 patients) validation (130 patients). Sensitivity, specificity, positive predictive value (PPV), negative (NPV) their 95% CI...
Aim: Acromioclavicular joint dislocation is one of the most common shoulder problems and may lead to instability or degenerative changes. The aim this study was compare clinical outcomes Tight Rope system clavicular hook plate for Rockwood type III acromioclavicular in adults. Materials Methods: This a prospective, randomized hospital setting. From January 2012 December 2014, 69 patients with injury were reviewed. Patients randomly divided into two groups: Group A treated using TightRope B...
Background and purposeRadiotherapy (RT) has a promising anti-tumor effect depending on its effects both cancer cells tumor immune microenvironment (TIME). As one of the most common alterations in hepatocellular carcinoma (HCC), wnt/β-catenin pathway activation, been reported to induce radioresistance suppressive TIME. In this study, we aim explore inhibitor ICG-001 radiosensitivity RT-related TIME HCC underlying mechanism.Materials methodsC57BL/6 nude mouse models were used evaluate efficacy...
Abstract Background Implant choice for the fixation of femoral neck fracture is one most important management controversies. This study aims to evaluate and compare short-term outcomes associated with use Femoral Neck System (FNS), Multiple Cancellous Screws (MCS), Dynamic Hip (DHS) in treating fractures a young patient population. Methods From June 2018 2021, total 120 surgeries primary were retrospectively analyzed. review encompassed demographic details patients mechanisms behind...
Abstract Purpose: To investigate the antitumor effects of targeting Src and tubulin in mucinous ovarian carcinoma. Experimental Design: The vitro vivo molecular mechanisms KX-01, which inhibits pathway polymerization, were examined cancer models. Results: In studies using RMUG-S RMUG-L cell lines showed that KX-01 inhibited proliferation, induced apoptosis, arrested cycle at G2–M phase, enhanced cytotoxicity oxaliplatin KX-01–sensitive line, RMUG-S. significantly decreased tumor burden mouse...
Laminar closure is associated with expansive open-door laminoplasty. Suture anchor fixation and titanium miniplate are used to prevent laminar reclosure. However, few studies have compared the clinical effects of 2 methods. The authors performed a prospective study 55 patients cervical spondylotic myelopathy who underwent single laminoplasty suture (n=30) or (n=25) from June 2005 May 2011. Clinical radiologic outcomes were evaluated at 1 week year postoperatively. There no significant...
The present study aimed to determine the expression of autophagy and investigate whether hypoxia‑inducible factor 1α (HIF‑1α)/BCL2 interacting protein (BNIP3)/Beclin‑1 signaling pathway serves an important role in activating varicocele (VC) rat testes cells. Furthermore, current explain possible association between apoptosis. A total 48 adult male Sprague Dawley rats were divided into group (control), B (VC 15‑day), C 30‑day) D 45‑day), with 12 each group. did not receive any interventions,...
The aim of this study was to evaluate the in vitro and vivo biocompatibility artificial bone based on vancomycin loaded mesoporous silica nanoparticles calcium sulfate composites. In cytotoxicity tests by cholecystokinin octapeptide (CCK-8) assay showed that 5 %Van-MSN-CaSO4 Van-CaSO4 cements were cytocompatible for mouse osteoblastic cell line MC3T3-E1. microscopic observation confirmed MC3T3-E1cells incubated with group exhibited clear spindle-shaped changes, volume increase maturation,...
Background Rheumatoid arthritis (RA) is a long-term autoimmune disorder characterized by chronic inflammation that results in swollen and painful joints even cartilage bone damage. The gut microbiota, novel anti-inflammatory target, considered an important environmental factor the development of RA. S-propargyl-cysteine (SPRC), amino acid analogue, exerts anti-inflammatory, cardioprotective effects, neuroprotective effects on various diseases. In recent studies, SPRC treatment exerted...