A5077498823- Sphingolipid Metabolism and Signaling
- Ion channel regulation and function
- Osteoarthritis Treatment and Mechanisms
- Ion Transport and Channel Regulation
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Natural product bioactivities and synthesis
- Cancer, Stress, Anesthesia, and Immune Response
- Liver physiology and pathology
- Diabetes Treatment and Management
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Particle physics theoretical and experimental studies
- Ion Channels and Receptors
- Cell Adhesion Molecules Research
- Quantum Chromodynamics and Particle Interactions
- HER2/EGFR in Cancer Research
- Neuropeptides and Animal Physiology
- Autoimmune and Inflammatory Disorders Research
- Pain Mechanisms and Treatments
Second Hospital of Anhui Medical University
2016-2025
Anhui Medical University
2016-2025
Shenzhen Children's Hospital
2024-2025
Fourth Affiliated Hospital of Guangxi Medical University
2024-2025
Nanjing University of Science and Technology
2024-2025
Shenzhen University
2025
Wuhan University
2014-2025
Renmin Hospital of Wuhan University
2014-2025
Shanxi Medical University
2019-2025
Jiangxi Agricultural University
2025
The in vivo alterations organ-specific substrate processing and endogenous mediator production induced by endotoxin were investigated healthy volunteers. An bolus (20 U/kg) produced increased energy expenditure, hyperglycemia, hypoaminoacidemia, an increase circulating free fatty acids. These changes included peripheral lactate acid output, along with uptake of glucose. Coordinately, there splanchnic oxygen, lactate, amino acids, glucose output. There no glucagon, or insulin transient...
Chronic stress is associated with hormonal changes that are known to affect multiple systems, including the immune and endocrine but effects of on cancer growth progression not fully understood. Here, we demonstrate human ovarian cells exposed either norepinephrine or epinephrine exhibit lower levels anoikis, process by which enter apoptosis when separated from ECM neighboring cells. In an orthotopic mouse model cancer, restraint increases in protected tumor anoikis promoted their activating...
In plants, calcium-dependent protein kinases (CDPKs) are involved in tolerance to abiotic stresses and plant seed development. However, the functions of only a few rice CDPKs have been clarified. At present, it is unclear whether also play role regulating spikelet fertility.We cloned characterized CDPK gene, OsCPK9. OsCPK9 transcription was induced by abscisic acid (ABA), PEG6000, NaCl treatments. The results overexpression (OsCPK9-OX) RNA interference (OsCPK9-RNAi) analyses revealed that...
beta 2-IFN/hepatocyte stimulating factor/IL-6 is a cytokine secreted by monocytes, fibroblasts, and endothelial cells in cell culture that possesses diverse biologic activity including the stimulation of acute phase plasma protein synthesis immunomodulation. The circulating levels this man response to bacterial LPS (endotoxin) were studied. A single i.v. bolus endotoxin (20 U/kg) produced monophasic rise immunoreactive IFN-beta 2/IL-6 bioactivity (hepatocyte B differentiation assays) peaking...
Perfluorooctanesulfonic acid (PFOS) is an organic contaminant ubiquitous in the environment, wildlife, and humans. Few studies have assessed its chronic toxicity on aquatic organisms. The present study defined effects of long-term exposure to PFOS zebrafish development reproduction. Specifically, at 8 h postfertilization (hpf) were exposed 0, 5, 50, 250 µg/L for five months. Growth suppression was observed PFOS-treated group. sex ratio altered, with a significant female dominance high-dose...
Cultivating new crop cultivars with multiple abiotic stress tolerances is important for production. The abscisic acid-stress-ripening (ASR) protein has been shown to confer tolerance in plants. However, the mechanisms of ASR function under condition remain largely unclear. In this study, we characterized all family members common wheat and constitutively overexpressed TaASR1-D a commercial hexaploid cultivar Zhengmai 9023. transgenic plants exhibited increased stresses grain yields salt...
Energetic materials containing a pyrazolotriazine oxide skeleton have the potential for high performance. However, research on is very limited due to inherent ring system instability and synthetic approaches. In this paper, APTO OPTO with combination of high-nitrogen tetrazole promising azido-pyrazolotriazine been synthesized. Of these, its energetic salts exhibit excellent detonation properties (Dv > 8220 m s–1; P 26.50 GPa). Surprisingly, exhibits performance = 8913 32.43 GPa) comparable that RDX.
Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, promotes cell proliferation and survival whereas its precursor, sphingosine, has the opposite effects. However, much remains unknown about their regulation. Here we identify novel human ceramidase (haCER2) that regulates levels of both sphingosine S1P by controlling hydrolysis ceramides. haCER2 is localized to Golgi complex highly expressed in placenta. High ectopic expression caused fragmentation growth arrest HeLa cells due...
SUMMARY Aims: Pioglitazone, known as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist, is used to treat type 2 diabetes mellitus (T2DM). T2DM has been associated with reduced performance on numerous domains of cognitive function. Here, we investigated the effects pioglitazone memory impairment in mouse model defects insulin sensitivity and secretion, namely high‐fat diet (HFD) streptozotocin (STZ)‐induced diabetic mice. Methods: ICR mice were fed HFD for 4 weeks then injected...
Much data implicate saturated fatty acids in deleterious processes associated with obesity, diabetes, and the metabolic syndrome. Many of these changes may be due to aberrant generation bioactive lipids when acid availability tissues is increased. On other hand, studies are emerging that monounsaturated oleate protection from fat mediated toxicity; however, mechanisms not well understood. Our demonstrate a novel role for palmitate increasing mRNA encoding DES1, which enzyme responsible...
Background: Acid-sensing ion channel 1a (ASIC1a), the primary acid sensors in nervous system, has been studied earlier various physiopathologic conditions. However, little is known about role of ASIC1a endplate chondrocytes intervertebral discs (IVDs). Methods: The expression ASICs was examined rat chondrocytes. Effects treatment with small interfering RNA (siRNA) or selective blocker (PcTX1) on acid-induced intracellular Ca2+ concentration ([Ca2+]i) and cell apoptosis were investigated....
The concomitant administration of ritonavir and oxycodone may significantly increase the plasma concentrations oxycodone. This study was aimed to simulate DDI between oxycodone, a widely used opioid, formulate dosing protocols for by using physiologically based pharmacokinetic (PBPK) modeling. We developed PBPK model incorporating induction competitive time-dependent inhibition CYP3A4 CYP2D6. evaluated with observed clinical data validated its potency. then drug interactions under various...
Ceramide has been shown to cause anoikis, a subtype of apoptosis due inadequate cell adhesion. However, the underlying mechanism is unclear. Herein, we report that D-e-C 6 -ceramide (D-e-Cer), via generating sphingosine, disrupts Golgi complex (GC), which associated with various cellular effects, including anoikis. Treatment HeLa cells D-e-Cer caused elongation, spreading inhibition, rounding, and detachment before (anoikis). In D-e-Cer–treated cells, glycosylation β1 integrin in GC was...
Ceramides with different fatty acyl chains may vary in their physiological or pathological roles; however, it remains unclear how cellular levels of individual ceramide species are regulated. Here, we demonstrate that our previously cloned human alkaline ceramidase 3 (ACER3) specifically controls the hydrolysis ceramides carrying unsaturated long chains, long-chain (ULC) ceramides. In vitro, ACER3 only hydrolyzed C(18:1)-, C(20:1)-, C(20:4)-ceramides, dihydroceramides, and phytoceramides....
Studies in skeletal muscle demonstrate that elevation of plasma FFAs increases the sphingolipid ceramide. We aimed to determine impact FFA oversupply on total profiles a model. C2C12 myotubes were treated with palmitate (PAL). Lipidomics analysis revealed pleiotropic effects PAL cell sphingolipids not limited ceramides. (13)C labeling demonstrated activated several branches synthesis by distinct mechanisms. Intriguingly, increased sphingosine-1-phosphate independently de novo synthesis....