A5003577703- Computational Drug Discovery Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Analytical Chemistry and Chromatography
- Machine Learning in Bioinformatics
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Chemical Synthesis and Analysis
- Quantum Dots Synthesis And Properties
- HIV/AIDS drug development and treatment
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Tryptophan and brain disorders
- Higher Education and Teaching Methods
- Stress Responses and Cortisol
- Nanoplatforms for cancer theranostics
- Drug Transport and Resistance Mechanisms
- Synthesis and biological activity
- Peroxisome Proliferator-Activated Receptors
- Monoclonal and Polyclonal Antibodies Research
- Essential Oils and Antimicrobial Activity
- RNA modifications and cancer
- Advanced Glycation End Products research
Beijing Shijitan Hospital
2019-2025
Capital Medical University
2008-2025
Huazhong University of Science and Technology
2017-2025
Tongji Hospital
2017-2025
Kunming Medical University
2005-2025
Gansu University of Traditional Chinese Medicine
2024-2025
Qilu University of Technology
2025
Shandong Academy of Sciences
2025
Chongqing University
2014-2024
Guangzhou Xinhua University
2024
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost uncertainty of development. Clinical data suggest that many such involve immune mechanisms, genetic association studies have identified strong linkage between hypersensitivity several drugs specific HLA alleles. One strongest associations found has been for antiviral abacavir, which causes severe exclusively in patients expressing...
Exploring a rational delivery system of integrating chemotherapy with immunotherapy to broaden benefits cancer immunochemotherapy is still under challenge. Herein, we developed doxorubicin (DOX)-loaded biomimetic hybrid nanovesicles (DOX@LINV) via fusing artificial liposomes (LIPs) tumor-derived (TNVs) for combinational immunochemotherapy. DOX@LINV homologous targeting ability could deliver DOX tumor tissue and elicit an effective immunogenic cell death response improve the immunogenicity...
CdTe/CdS/ZnS corre-shell-shell (CSS) quantum dots (QDs) are synthesized in the aqueous phase assisted by microwave irradiation. As-prepared CSS QDs suitable novel fluorescent probes biological applications because of their outstanding dispersibility, good spectral properties, excellent photostability, and favorable biocompatibility.
Sensitive and selective detection for cancer biomarkers are critical in clinical diagnostics. Here we developed a microfluidic protein chip an ultrasensitive multiplexed assay of biomarkers. Aqueous-phase-synthesized CdTe/CdS quantum dots (aqQDs) were employed as fluorescent signal amplifiers to improve the sensitivity. Secondary antibodies (goat anti-mouse IgG) conjugated luminescent QDs realize versatile probe that could be used both sandwich reverse phase immunoassays. We found our not...
Abstract Increasing evidence suggests that depression may be associated with a lack of hippocampal neurogenesis. It is well established neuronal nitric oxide synthase (nNOS)‐derived NO exerts negative control on the Using genetic and pharmacological methods, we investigated roles nNOS in induced by chronic mild stress (CMS) mice. Hippocampal over‐expression was first observed 4 days remained elevated 21 56 after exposure to CMS. The mice exposed CMS exhibited behavioral changes typical...
Abstract In this work, a new set of amino acid descriptors, i.e., VHSE (principal components score V ectors H ydrophobic, S teric, and E lectronic properties), is derived from principal analysis (PCA) on independent families 18 hydrophobic properties, 17 steric 15 electronic respectively, which are included in total 50 physicochemical variables 20 coded acids. Using the stepwise multiple regression (SMR) method combined with partial least squares (PLS), scales then applied to QSAR studies...
Water-dispersed nanocrystals with high photoluminescence quantum yield (PLQY) and narrow size distribution are desirable for a variety of bioapplications. In this report, we present facile method assisted by microwave irradiation rapidly synthesizing high-quality CdTe in aqueous phase. The PLQY prepared very short time (15 min) reaches as 82%, the fwhm value is merely 27 nm meanwhile. Moreover, increased to remarkable 98% after further amelioration through illumination method. key synthesis...
Blocking immune checkpoints with monoclonal antibody has been verified to achieve potential clinical successes for cancer immunotherapy. However, its application impeded by the "cold" tumor microenvironment. Here, weak acidity-responsive nanoparticles co-loaded CRISPR/Cas9 and paclitaxel (PTX) ability convert into "hot" are reported. The exhibited high cargo packaging capacity, superior transfection efficiency, well biocompatibility, effective accumulation. encapsulated in could specifically...
The cytotoxicity of the natural ent-kaurene diterpenoid, oridonin, has been extensively studied. However, application oridonin for cancer therapy was hampered primarily by its moderate potency. In this study, a series A-ring modified analogues, and their derivatives bearing various substituents on 14-OH position, were designed, synthesized, evaluated anticancer efficacy. Some significantly more potent than against both drug-sensitive drug-resistant cells. most compound, 13p, 200-fold...
Understanding the mechanisms underlying phenotypic innovation is a key goal of comparative genomic studies. Here, we investigated evolutionary landscape lineage-specific accelerated regions (LinARs) across 49 primate species. Genomic comparison with dense taxa sampling species significantly improved LinAR detection accuracy and revealed many novel human LinARs associated brain development or disease. Our study also yielded detailed maps in other lineages that may have influenced adaptation....
ABSTRACT Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs part through alterations penicillin-binding proteins (PBPs) and a decrease outer membrane permeability. However, the genetic molecular mechanisms of transformation penicillin-susceptible strain N. to high-level have not been clearly elucidated. Previous studies suggested that PBP 1 were involved resistance. In this study, we identified single amino acid mutation located 40 acids N terminal active-site...
ABSTRACT Neisseria gonorrhoeae becomes resistant to tetracycline by two major mechanisms: expression of a plasmid-encoded TetM protein and mutations in endogenous genes (chromosomally mediated resistance). Early studies Sparling colleagues (P. F. A. J. Sarubbi, E. Blackman, Bacteriol. 124:740-749, 1975) demonstrated that three were involved high-level chromosomally resistance (MIC ≥ 2 μg/ml): ery-2 (now referred as mtrR ), penB , tet-2 . While the identities first are known, gene has not...
SUMMARY Aims: Pioglitazone, known as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist, is used to treat type 2 diabetes mellitus (T2DM). T2DM has been associated with reduced performance on numerous domains of cognitive function. Here, we investigated the effects pioglitazone memory impairment in mouse model defects insulin sensitivity and secretion, namely high‐fat diet (HFD) streptozotocin (STZ)‐induced diabetic mice. Methods: ICR mice were fed HFD for 4 weeks then injected...