A5083506671- Natural product bioactivities and synthesis
- Phytochemical Studies and Bioactivities
- Phytochemical compounds biological activities
- Chromatography in Natural Products
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Reproductive System and Pregnancy
- Traditional and Medicinal Uses of Annonaceae
- Galectins and Cancer Biology
- Phytochemistry and Bioactive Compounds
- Neuroscience and Neural Engineering
- Endometriosis Research and Treatment
- Aortic Disease and Treatment Approaches
- Cocoa and Sweet Potato Agronomy
- Antiplatelet Therapy and Cardiovascular Diseases
- Computational Drug Discovery Methods
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Atherosclerosis and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac Fibrosis and Remodeling
- Cerebrovascular and Carotid Artery Diseases
Capital Medical University
2012-2024
Beijing Anzhen Hospital
2009-2023
Air Force Medical University
2017-2018
Tongji Hospital
2014-2018
Huazhong University of Science and Technology
2010-2018
China Three Gorges University
2006-2016
Jiangxi University of Science and Technology
2015
Pudong New Area People's Hospital
2014
Union Hospital
2010-2011
University of Hong Kong
2009
Abstract In this work, a new set of amino acid descriptors, i.e., VHSE (principal components score V ectors H ydrophobic, S teric, and E lectronic properties), is derived from principal analysis (PCA) on independent families 18 hydrophobic properties, 17 steric 15 electronic respectively, which are included in total 50 physicochemical variables 20 coded acids. Using the stepwise multiple regression (SMR) method combined with partial least squares (PLS), scales then applied to QSAR studies...
Although fibroblast-to-myocyte electrical coupling is experimentally suggested, electrophysiology of cardiac fibroblasts not as well established contractile myocytes. The present study was therefore designed to characterize ion channels in cultured human fibroblasts.A whole-cell patch voltage clamp technique and RT-PCR were employed determine expression their molecular identities. We found that multiple heterogeneously expressed fibroblasts. These include a big conductance Ca(2+)-activated...
Calsequestrins (Casqs), comprising the Casq1 and Casq2 isoforms, buffer Ca2+ regulate its release in sarcoplasmic reticulum of skeletal cardiac muscle, respectively. Human inherited diseases associated with mutations CASQ1 or CASQ2 include malignant hyperthermia/environmental heat stroke (MH/EHS) catecholaminergic polymorphic ventricular tachycardia. However, patients an MH/EHS event often experience arrhythmia for which underlying mechanism remains unknown.Working hearts from conventional...
Abstract Three new arylnaphthalide lignans named 6′‐hydroxy justicidin A (1), B (2) and C (3) have been isolated from the whole plant of Justicia procumbens , together with four known ones, neojusticin (4), chinensinaphthol methyl ester (5), isodiphyllin (6) taiwanin (7). The complete assignments 1 H 13 NMR chemical shifts for were obtained first time by means 2D techniques, including HSQC HMBC. Copyright © 2006 John Wiley & Sons, Ltd.
Previous studies have reported conflicting findings regarding the relation of body mass index (BMI) to outcomes following percutaneous coronary interventions (PCI). No study date has directly examined effect obesity on cardiovascular thrombotic events after stent implantation.To evaluate in patients undergoing PCI with drug-eluting stents.We studied 4972 between January 2004 and December 2006. Patients were divided into three groups according index: normal (BMI <24.9 kg/m(2), n = 1284),...
OBJECTIVE Isolated spinal aneurysms (ISAs) are rare causes of subarachnoid hemorrhage (SAH), which encompass a highly heterogeneous group clinical entities with multifarious pathogeneses, characteristics, and treatment strategies. Therefore, knowledge about the ISAs remains inadequate. In this study, authors present comprehensive analysis data associated at their institutions to enhance understanding disease. METHODS Patients confirmed by angiography or surgery authors’ between 2015 2022...
Three new polyhydroxylated phragmalins, named xyloccensins Y, Z1, and Z2 (1−3), were isolated from the fruit of a Chinese mangrove, Xylocarpus granatum, together with eight known compounds. The structures these compounds established on basis spectroscopic data chemical methods.
Recurrent miscarriage is defined as the loss of 3 or more consecutive pregnancies; however, underlying immunologic mechanisms that trigger pregnancy remain largely unelucidated. Galectin-9 (Gal-9) may modulate a variety biologic functions and play an important role in Th1/Th2 immune deviation. To analyze mechanism Gal-9 abortion, we used classical abortion-prone mouse model (DBA/2-mated CBA/J mice) to detect expression at maternal-fetal interface. We also mimicked environment by culturing...
A novel 18-norspirostanol saponin (1), along with Trillenoside (2), was obtained from the underground parts of Trillium tschonoskii MAXIM., collected in Shennongjia Forest District, China. Based on chemical and spectroscopic evidences, their structures were determined as shown Fig. 1. 1 2 displayed marked inhibitory action towards COX-2 production macrophagocytes mouse abdominal cavity stimulated by LPS at 10 μg/ml.
Four new mexicanolides with a Δ14,15 double bond, named xylogranatins A and D (1—4), were isolated from the fruit of Chinese mangrove Xylocarpus granatum, together two known 8,9,30-phragmalin ortho esters, xyloccensins P Q. Their structures elucidated on basis spectroscopic data, especially 2D NMR techniques including HSQC, HMBC NOESY.
Two new mexicanolides, named xyloccensins X 1 and 2 (1 - 2), were isolated from the fruit of Chinese mangrove Xylocarpus granatum. Their structures elucidated on basis spectroscopical data, especially 2D NMR techniques including HSQC, HMBC, NOESY.
Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on basis chemical spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen...
Two new spirostanols and a furostanol, reinocarnoside A (1), B (2) C (3), were isolated from the roots of Reineckia carnea, together with two known compounds, (25S)-1β,3β,4β-trihydroxyspirostan-5β-yl-O-β-D-glucopyranoside (4), kitigenin-5β-O-β-D-glucopyranoside (5). The structures three compounds elucidated by spectroscopic methods including 1-D NMR, 2-D NMR MS spectrums, their anticancer activities evaluated MTT method.
The Cu-S separation tests have been conducted at pH=7∼8 with five combined depressants, namely, Starch + pyrogallic acid, sodium hypochlorite acid Tannic, Tannic and calcium DT-2#. show that DT-2# is the best depressor for pyrite, which leads to a low alkalinity of without lime. From chemical analysis mineral surface, inhibition mechanism pyrite pH 7∼8 as following: oxidizes surface produce hydrophilous film Fe(OH)3 CaCO3, enhances hydrophilicity then inhibited in pulp, can be achieved...
Cardiac c-kit(+) cells are generally believed to be the major population of stem/progenitor in heart and can used as a cell source for cardiomyoplasty; however, cellular electrophysiological properties not understood this type cells. The present study was designed investigate functional ion channels undifferentiated mouse cardiac using approaches whole patch voltage clamp, RT-PCR, proliferation assay. It found that three types ionic currents were cells, including delayed rectifier K(+)...
Abstract Four new furostanol saponins (1–4), two pairs of diastereoisomers, were isolated from methanolic extracts T upistra chinensis rhizomes and their structures assigned 1 H 13 C NMR spectra, DEPT, by 2D COSY, NOESY, HMQC, HMBC experiments. Copyright © 2008 John Wiley & Sons, Ltd.