A5100747907- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- IgG4-Related and Inflammatory Diseases
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Tumors Diagnosis and Treatment
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Poxvirus research and outbreaks
- Glycosylation and Glycoproteins Research
- Immune cells in cancer
- Neuroendocrine Tumor Research Advances
- Bioinformatics and Genomic Networks
- Vibrio bacteria research studies
- Gastrointestinal Tumor Research and Treatment
Capital Medical University
2009-2025
Chinese PLA General Hospital
2022-2025
South China University of Technology
2025
North China University of Science and Technology Affiliated Hospital
2025
Beijing Tian Tan Hospital
2020-2025
National Clinical Research Center for Digestive Diseases
2020-2024
Peking University
2013-2024
Nanjing Medical University
2019-2024
State Key Laboratory of Reproductive Medicine
2024
Weihai Municipal Hospital
2024
Hepatocellular carcinoma (HCC) cells often invade the portal venous system and subsequently develop into vein tumour thrombosis (PVTT). Long noncoding RNAs (lncRNAs) have been associated with HCC, but a comprehensive analysis of their specific association HCC metastasis has not conducted. Here, by analysing 60 clinical samples' RNA-seq data from 20 patients, we identified characterized 8,603 candidate lncRNAs. The expression patterns 917 recurrently deregulated lncRNAs are correlated in TCGA...
Article29 August 2018Open Access Source DataTransparent process Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response Yusheng Wu Tsinghua-Peking Joint Center for Life Sciences, Beijing, China MOE Key Laboratory Bioinformatics, Tsinghua University, Synthetic & Systems Biology, School Search more papers this author Wenwei Zhao Yang Liu Graduate Program Peking-Tsinghua-National Institute Biological Science, Xiangtian Tan Xin Li Qin Zou Zhengtao Xiao Hui...
DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding biology. Most sequencing approaches address either genetics or epigenetics thus capture incomplete information. Methods widely used detect bases fail common C-to-T mutations distinguish 5-methylcytosine from 5-hydroxymethylcytosine. We present a single base-resolution methodology that sequences complete the two most cytosine modifications workflow. is copied enzymatically...
DNA-templated affinity labeling: Accurate characterization of small-molecule (SM)–protein interactions is one the most important but also very challenging tasks in chemical biology and drug discovery. A novel method named DNA-programmed photoaffinity labeling reported. The introduction DNA encoding template effect enable multiplexed protein by multiple probes.
Ischemic stroke is a leading cause of global mortality and long-term disability. However, there paucity whole-genome sequencing studies on ischemic stroke, resulting in limited knowledge the interplay between genomic phenotypic variations among affected patients. Here, we outline STROMICS design present first analysis by deeply analyzing 10,241 patients from China. We identified 135.59 million variants, > 42% which were novel. Notable disparities allele frequency observed Chinese other...
Colorectal cancer (CRC) arises from complex interactions between host and environment, which include the gut tissue microbiome. It is hypothesized that epigenetic regulation by microbiota a fundamental interface commensal microbes dynamically influence intestinal biology. The aim of this study to explore interplay DNA methylation in CRC.
Aberrant methylation in gene promoter regions leads to transcriptional inactivation of cancer-related genes and plays an integral role tumorigenesis. This alteration has been investigated lung tumors primarily from smokers, whereas only a few studies involved never-smokers. Here, we applied methylation-specific polymerase chain reaction compare the frequencies methylated p16 O6-methylguanine-DNA methyltransferase (MGMT) 122 patients with non-small cell cancer, including 81 smokers 41...
Abstract Navigation requires not only the execution of locomotor programs but also high arousal and real-time retrieval spatial memory that is often associated with hippocampal theta oscillations. However, neural circuits for coordinately controlling these important processes remain to be fully dissected. Here we show activity neuromedin B (NMB) neurons in nucleus incertus (NI) tightly correlated mouse speed, level, power. These are reversibly suppressed by optogenetic inhibition rapidly...
Glioma is a type of aggressive and incurable brain tumor. Patients with glioma are highly resistant to all types therapies, including immunotherapies. Epigenetic reprogramming key molecular hallmark in tumors across cancer types, glioma. Mounting evidence highlights pivotal role epigenetic regulation shaping tumor biology therapeutic responses through mechanisms involving both cells immune cells, as well their symbiotic interactions the microenvironment (TME). In this review, we discuss that...
// Qinyuan Liao 1, 2, * , Wei Liu Yang Fulin Wang 4 Chong 2 Jingxuan Zhang 3 Ming Chu Dongyang Jiang Lin Xiao Wenwei Shao Zhengzuo Sheng 1 Xia Tao 5 Lei Huo 6 C. Cameron Yin 7 Youhui 8 Gregory Lee 9 Jing Huang Zihai Li 10 Xiaoyan Qiu Department of Immunology, School Basic Medical Sciences, Peking University, Beijing, 100191, China University Center for Human Disease Genomics, Key Laboratory Ministry Health, Pathology, Chinese PLA General Hospital, 100853, Gynecology, First 100034, Division...
The limited number of human hematopoietic stem cells (HSCs) has restrained their widespread clinical application. Despite great efforts in recent years, the vitro expansion HSCs remains a challenge due to incomplete understanding signaling networks underlying HSC self-renewal. Here, we show that culturing cord blood (CB) CD34+ with JNK-IN-8, an inhibitor JNK pathway, can enhance self-renewal 3.88-fold increase cell number. These cultured repopulated recipient mice for 21 weeks and form...
Upregulation of histone methyltransferase SET domain bifurcated 1 (SETDB1) is associated with poor prognosis in cancer patients. However, the mechanism oncogenicity SETDB1 hitherto unknown. Here, we show that upregulated human colorectal (CRC) where its level correlates clinical outcome. Ectopic promotes CRC cell proliferation, whereas attenuation inhibits this process. Flow cytometry reveals proliferation by driving cycle from G0/G1 phase to S phase. Mechanistically, binds directly STAT1...
One of the main challenges in small molecule drug discovery is finding novel chemical compounds with desirable activity. Traditional development typically begins target selection, but correlation between targets and disease remains to be further investigated, drugs designed based on may not always have desired efficacy. The emergence machine learning provides a powerful tool overcome challenge. Herein, learning-based strategy developed for de novo generation efficacy termed DTLS (Deep...