A5031494622- Radiation Detection and Scintillator Technologies
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Medical Imaging Techniques and Applications
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Transcranial Magnetic Stimulation Studies
- Heavy metals in environment
- Plant Pathogens and Fungal Diseases
- Functional Brain Connectivity Studies
- Higher Education and Teaching Methods
- Mycorrhizal Fungi and Plant Interactions
- Nuclear Physics and Applications
- Translation Studies and Practices
- Ion Channels and Receptors
- Nitric Oxide and Endothelin Effects
- Neurological disorders and treatments
- biodegradable polymer synthesis and properties
- Acute Myeloid Leukemia Research
- Advanced X-ray and CT Imaging
- Maternal Mental Health During Pregnancy and Postpartum
- Pulmonary Hypertension Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Photoreceptor and optogenetics research
- Advanced MRI Techniques and Applications
University of York
2024-2025
Cold Spring Harbor Laboratory
2020-2024
Center for Excellence in Brain Science and Intelligence Technology
2016-2024
Chinese Academy of Sciences
2006-2024
General Hospital of Shenyang Military Region
2017-2024
Fujian University of Traditional Chinese Medicine
2024
China Medical University
2024
Lanzhou University
2024
Beihang University
2023
Tsinghua University
2022
Defense is a basic survival mechanism when animals face danger. Previous studies have suggested that the midbrain periaqueductal gray (PAG) essential for generation of defensive reactions. Here we showed optogenetic activation neurons in PAG mice was sufficient to induce series responses (including running, freezing, and avoidance). However, endogenous neural dynamics underlying behaviors still remain elusive. Using chronic extracellular recording, recorded spiking activities freely behaving...
Piperlongumine (PL), a natural product isolated from the plant species Piper longum L., can selectively induce apoptotic cell death in cancer cells by targeting stress response to reactive oxygen (ROS). Here we show that PL induces presence of benzyloxycarbonylvalyl-alanyl-aspartic acid (O-methyl)-fluoro-methylketone (zVAD-fmk), pan-apoptotic inhibitor, and necrostatin-1, necrotic inhibitor. Instead PL-induced be suppressed 3-methyladenine, an autophagy substantially attenuated lacking...
Abstract The anterior cingulate cortex (ACC) has long been thought to regulate conflict between an object of attention and distractors during goal-directed sustained attention. However, it is unclear whether ACC serves itself. Here, we developed a task in which the time course could be controlled rats. Then, using pharmacological lesion experiments, employed assess function We then recorded neuronal activity multichannel extracellular recording techniques identified specific neurons...
The limited number of human hematopoietic stem cells (HSCs) has restrained their widespread clinical application. Despite great efforts in recent years, the vitro expansion HSCs remains a challenge due to incomplete understanding signaling networks underlying HSC self-renewal. Here, we show that culturing cord blood (CB) CD34+ with JNK-IN-8, an inhibitor JNK pathway, can enhance self-renewal 3.88-fold increase cell number. These cultured repopulated recipient mice for 21 weeks and form...
Conducting risk and early warning assessments of heavy metals (HMs) pollution in agricultural soils holds significant importance for prevention sustainable development. Early studies on metal contamination oases arid zones are rare previous studies, therefore, this study carried out spatial temporal simulation the environmental capacity Hexi Corridor based field monitoring data remote sensing technology other methods. The results revealed that have been affected by human activities, leaving...
Diallyl trisulfide (DATS), the major active ingredient in garlic, has been reported to confer cardioprotective effects. However, its effect on myocardial ischemia-reperfusion (MI/R) injury diabetic state and underlying mechanism are still unknown. We hypothesize that DATS reduces MI/R via AMPK-mediated AKT/GSK-3β/HIF-1α activation. Streptozotocin-induced rats received surgery with or without (20mg/kg) treatment presence absence of Compound C (Com.C, an AMPK inhibitor, 0.25mg/kg) LY294002 (a...
Abstract Diabetic nephropathy (DN) is one of the major complications diabetes mellitus (DM). This study aimed to explore effects corosolic acid (CA) on renal damage DM and mechanisms behind these effects. The renoprotective effect CA was investigated in type 1 diabetic rats db/db mice. kidneys glomerular mesangial cells (GMCs) were used proliferation GMCs by immunostaining MTT assay. Further immunoblotting, siRNA, qPCR analysis detecting NADPH oxidase activity reactive oxygen species (ROS)...
Abstract Intracellular Ca 2+ dysregulation is a key marker in septic cardiac dysfunction; however, regulation of the classic regulatory modules cannot successfully abolish this symptom. Here we show that knockout transient receptor potential canonical (TRPC) channel isoforms TRPC1 and TRPC6 can ameliorate LPS-challenged heart failure prolong survival mice. The LPS-triggered release from endoplasmic reticulum both cardiomyocytes macrophages significantly inhibited by Trpc1 or Trpc6 knockout....
Biodegradable polylactic acid (PLA) mulch has been developed to replace conventional polyethylene (PE) in agriculture as a response growing concerns about recalcitrant plastic pollution and the accumulation of microplastics (MPs) soil.Cadmium is significant soil pollutant China.MPs have shown adsorb metals.In this study earthworm Lumbricus terrestris was exposed either Cd (1.0-100 mg / kg) or MPs (PE PLA, 0.1-3 % w w), combination two, for 28 days.Cd bioavailability significantly decreased...
SMLC protects against atrial remodeling of AF by inhibiting oxidative stress through the mediation MsrA/p38 MAPK signaling pathway