A5011141578- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
- Genetics and Neurodevelopmental Disorders
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Neural dynamics and brain function
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Hearing, Cochlea, Tinnitus, Genetics
- RNA Research and Splicing
- Cell Image Analysis Techniques
- Pluripotent Stem Cells Research
- Receptor Mechanisms and Signaling
- Cognitive Abilities and Testing
- RNA regulation and disease
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Advanced Memory and Neural Computing
- Adipose Tissue and Metabolism
- Animal Ecology and Behavior Studies
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
Baylor College of Medicine
2019-2025
Neurological Research Institute
2019-2025
Texas Children's Hospital
2019-2025
Peking University
2014-2017
Hebei University
2011
The locus coeruleus (LC) houses the vast majority of noradrenergic neurons in brain and regulates many fundamental functions, including fight flight response, attention control, sleep/wake cycles. While efferent projections LC have been extensively investigated, little is known about its local circuit organization. Here, we performed large-scale multipatch recordings adult mouse to profile their morpho-electric properties while simultaneously examining interactions. are diverse could be...
Abstract Prior studies have described the complex interplay that exists between glioma cells and neurons, however, electrophysiological properties endogenous to tumor remain obscure. To address this, we employed Patch-sequencing on human specimens found one third of patched in IDH mutant (IDH mut ) tumors demonstrate both neurons glia by firing single, short action potentials. define these hybrid (HCs) discern if they are origin, developed a computational tool, Single Cell Rule Association...
Abstract The locus coeruleus (LC) houses the vast majority of noradrenergic neurons in brain and regulates many fundamental functions including fight flight response, attention control, sleep/wake cycles. While efferent projections LC have been extensively investigated, little is known about its local circuit organization. Here, we performed large-scale multi-patch recordings adult mouse to profile their morpho-electric properties while simultaneously examining interactions. are diverse...
Neurexophilins are secreted neuropeptide-like glycoproteins, and neurexophilin1 neurexophilin3 ligands for the presynaptic cell adhesion molecule α-neurexin. more selectively expressed in brain than α-neurexins, however, which led us to ask whether neurexophilins modulate function of α-neurexin a context-specific manner. We characterized expression neurexophilin4 mice found it be subsets neurons responsible feeding, emotion, balance, movement. Deletion Neurexophilin4 caused corresponding...
The cochlear nuclear complex (CN), the starting point for all central auditory processing, comprises a suite of neuronal cell types that are highly specialized neural coding acoustic signals, yet molecular logic governing cellular specializations remains unknown. By combining single-nucleus RNA sequencing and Patch-seq analysis, we reveal set transcriptionally distinct populations encompassing previously observed discover multiple new subtypes with anatomical physiological identity....
Ground squirrel, a hibernating mammalian species, is more resistant to ischemic brain stress than rat. Gaining insight into the adaptive mechanisms of ground squirrels may help us design treatment strategies reduce damage in patients suffering stroke. To understand anti-stress squirrel neurons, we studied glutamate toxicity primary cultured neurons Daurian (Spermophilus dauricus). At neuronal level, for first time, found that was excitotoxicity Mechanistically, displayed similar calcium...
Abstract Despite advances in molecular profiling, therapeutic development has been hindered by the inability to identify and target tumour-specific mechanisms without consequence healthy tissue. Correspondingly, a computational framework capable of accurately distinguishing tumour from non-tumour cells yet be developed cell annotation algorithms are unable assign integrated genomic transcriptional profiles single on cell-by-cell basis. To address these barriers, we Single Cell Rule...
Abstract Anti-seizure drug (ASD) targets are widely expressed in both excitatory and inhibitory neurons. It remains unknown if the action of an ASD upon neurons could counteract its beneficial effects on (or vice versa), thereby reducing efficacy ASD. Here, we examine whether retigabine (RTG) is altered after removal Kv7 potassium channel subunit KCNQ2, one targets, from parvalbumin-expressing interneurons (PV-INs). Parvalbumin-Cre (PV-Cre) mice were crossed with Kcnq2 -floxed ( fl/fl ) to...