A5052971827- Pluripotent Stem Cells Research
- Renal Diseases and Glomerulopathies
- CRISPR and Genetic Engineering
- Pancreatic function and diabetes
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Neurological Disease Mechanisms and Treatments
- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Corneal Surgery and Treatments
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Diabetes Management and Research
- Immunotherapy and Immune Responses
- Complement system in diseases
- Mitochondrial Function and Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Reconstructive Facial Surgery Techniques
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Hedgehog Signaling Pathway Studies
Hangzhou Hospital of Traditional Chinese Medicine
2013-2025
Changzhi Medical College
2019-2024
Soochow University
2021-2024
Peking University
2007-2024
Center for Life Sciences
2014-2024
Hebei Medical University
2011-2024
Second Hospital of Hebei Medical University
2011-2024
Tongji Hospital
2024
First Affiliated Hospital of Soochow University
2021-2024
Chinese Academy of Sciences
2024
Keep hepatocytes fresh Freshly isolated primary human (PHHs) quickly lose their identity and function in vitro, limiting application modeling infectious liver diseases screening drugs. Xiang et al. describe a simple effective five-chemical culture condition that can maintain the mature of cultured PHHs for an extended period time. this way support entire viral life cycle recapitulate long-term infection hepatitis B virus. This system created useful drug-screening platform developing new...
Depletion of CD8+ T cells is a major obstacle in immunotherapy; however, the relevant mechanisms remain largely unknown. Here, we showed that prostate cancer (PCa) cell-derived exosomes hamper cell function by transporting interleukin-8 (IL-8). Compared to low IL-8 levels detected immune cells, PCa secreted abundance and further accumulated exosomes. The delivery into exhausted through enhanced starvation. Mechanistically, exosomal overactivated PPARα recipient thereby decreasing glucose...
Terminally differentiated cells can be generated by lineage reprogramming, which is, however, hindered incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy mimicking the natural regeneration route, permits generating expandable hepatic progenitor functionally competent human hepatocytes. Fibroblasts were first induced into progenitor-like (hHPLCs), could robustly expand in vitro efficiently engraft vivo....
Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens tens thousands people with high morbidity and mortality world widely. The purpose our study was to investigate related genes HCC discover their potential abilities predict prognosis patients.We obtained RNA sequencing data from Cancer Genome Atlas (TCGA) database performed analysis on protein coding genes. Differentially expressed (DEGs) were selected. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes...
The interaction between programmed death receptor (PD-1) and its ligand (PD-L1) is essential for suppressing activated T-lymphocytes. However, the precise mechanisms underlying PD-L1 overexpression in tumours have yet to be fully elucidated. Here, we describe that RelB participates immune evasion of prostate cancer (PCa) via cis/trans transcriptional upregulation PD-L1.Based on transcriptome results, was manipulated multiple human murine PCa cell lines. Activated CD4+ CD8+ T cells were...
Abstract Extended pluripotent stem (EPS) cells have shown great applicative potentials in generating synthetic embryos, directed differentiation and disease modeling. However, the lack of a xeno-free culture condition has significantly limited their applications. Here, we report chemically defined system for culturing deriving human EPS vitro. Xeno-free can be long-term genetically stably maintained vitro, as well preserve embryonic extraembryonic developmental potentials. Furthermore, also...