Zhen Liang

ORCID: 0000-0002-6272-3453
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About
Contact & Profiles
Research Areas
  • Pancreatic function and diabetes
  • Gastric Cancer Management and Outcomes
  • Glycosylation and Glycoproteins Research
  • Pluripotent Stem Cells Research
  • Esophageal Cancer Research and Treatment
  • Glaucoma and retinal disorders
  • Retinal Diseases and Treatments
  • Metastasis and carcinoma case studies
  • Immune Cell Function and Interaction
  • Diabetes and associated disorders
  • Liver physiology and pathology
  • Diabetes Management and Research
  • Inhalation and Respiratory Drug Delivery
  • Air Quality and Health Impacts
  • Immunotherapy and Immune Responses
  • Pharmacological Effects and Toxicity Studies
  • Coordination Chemistry and Organometallics
  • Biosensors and Analytical Detection
  • Retinal Imaging and Analysis
  • Circadian rhythm and melatonin
  • Intestinal Malrotation and Obstruction Disorders
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Metabolism, Diabetes, and Cancer
  • Cancer-related gene regulation
  • Air Quality Monitoring and Forecasting

Hebei Medical University
2025

Second Hospital of Hebei Medical University
2025

Peking University
2005-2024

Center for Life Sciences
2022-2024

Dalian Institute of Chemical Physics
2003-2022

Chinese Academy of Sciences
2022

Peking University Cancer Hospital
2011-2020

King University
2020

Jinggangshan University
2019

National University Health System
2011

Keep hepatocytes fresh Freshly isolated primary human (PHHs) quickly lose their identity and function in vitro, limiting application modeling infectious liver diseases screening drugs. Xiang et al. describe a simple effective five-chemical culture condition that can maintain the mature of cultured PHHs for an extended period time. this way support entire viral life cycle recapitulate long-term infection hepatitis B virus. This system created useful drug-screening platform developing new...

10.1126/science.aau7307 article EN Science 2019-04-25

Signet-ring cell carcinoma is a poorly differentiated adenocarcinoma with high degree of malignancy, which rarely occurs in hilar bile duct. As far as I know, this the third signet-ring cholangiocarcinoma found so far. We used endoscopic ultrasound(EUS) and per-oral cholangioscopy(POCPS) to make definite diagnosis.

10.17235/reed.2025.11010/2024 article EN publisher-specific-oa Revista Española de Enfermedades Digestivas 2025-01-01

Chimeric antigen receptor (CAR) T cell therapy is a promising new class of hematological malignancy treatment. However, CAR cells are rarely effective in solid tumor mainly because the poor trafficking injected to site and their limited infiltration survival immunosuppressive hypoxic microenvironment (TME). Here, we built an injectable immune-microchip (i-G/MC) system intratumorally deliver enhance therapeutic efficacy tumors. In i-G/MC, oxygen carriers (Hemo) released disrupt TME, then,...

10.1021/acsami.0c15239 article EN ACS Applied Materials & Interfaces 2020-12-11

To evaluate the effects of glycemic control on refraction in diabetic patients.Twenty newly diagnosed patients were included this study. The random blood glucose, HbA1c levels, fasting C-peptide and postprandial 2h measured before treatment. with glucose higher than 12.0mmol/L level 10.0% selected. Refraction, intraocular pressure, radius anterior corneal curvature, depth chamber, lens thickness, vitreous length, axial length admission at end week 1, 2, 3 4 during control.A transient...

10.3980/j.issn.2222-3959.2010.02.15 article EN PubMed 2010-01-01

Colonic atresia (CA) is an unusual cause of neonatal intestinal obstruction where a section the colon has failed to form, leading blockage or absence. A premature baby was delivered at 32 weeks gestation via caesarian following fetal distress. She grossly oedematous and diagnosed with severe fetalis hydrops secondary anaemia. resuscitated stabilized. On sixth day life, neonate's abdomen became severely distended bilious vomiting failure pass meconium. We suspected performed omnipaque enema...

10.1258/smj.2011.011102 article EN Scottish Medical Journal 2011-05-01

Single-chain-Fv (scFv) display M13 phage library has been regarded as a powerful tool for screening specific antibodies via binding with target proteins. Generally, the quality is evaluated through detecting gene fragments by molecular biology methods, which not only time- and labor-consuming, but also impossible to obtain quantitative information about capacity of library. In our recent study, new method calculate average scFv number displayed on surface was proposed capillary...

10.1351/pac-con-09-02-03 article EN Pure and Applied Chemistry 2010-01-03

Malignant plural effusion (MPE) is one of the most common specimen for liquid biopsy gene detection. This study aims to explore a method isolating tumor cells from large volume MPE and evaluate its efficacy application prospect in

10.3779/j.issn.1009-3419.2020.103.18 article EN PubMed 2020-12-20

Abstract Exposure to airborne fine particulate matter (PM 2.5 ) induced various adverse health effects, such as metabolic syndrome, systemic inflammation and respiratory infection. Many works have studied the influence of PM exposure intracellular proteome underlying mechanism. But extracellular changes under exposure, correlation between secretome -induced cytotoxicity remains confusing. Herein, on normal human bronchial epithelia cells (BEAS-2B) was evaluated profile BEAS-2B before after...

10.21203/rs.3.rs-1055836/v1 preprint EN cc-by Research Square (Research Square) 2021-12-02
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