A5009218072- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Breast Cancer Treatment Studies
- Gastrointestinal disorders and treatments
- Long-Term Effects of COVID-19
- Pediatric Hepatobiliary Diseases and Treatments
- Wound Healing and Treatments
- Respiratory viral infections research
- Intestinal and Peritoneal Adhesions
- Gastrointestinal Bleeding Diagnosis and Treatment
- Mosquito-borne diseases and control
- Pregnancy and Medication Impact
- Porphyrin Metabolism and Disorders
- Viral Infections and Outbreaks Research
- Folate and B Vitamins Research
- Bacterial Infections and Vaccines
- Mesenchymal stem cell research
- Pelvic and Acetabular Injuries
- Hemostasis and retained surgical items
- Heat shock proteins research
- Hospital Admissions and Outcomes
- Pancreatic and Hepatic Oncology Research
National University Hospital
2018-2023
National University Health System
2020-2022
Subang Jaya Medical Centre
2020
Gleneagles Hospital
2018
National University of Singapore
2018
Monash Medical Centre
2016
Monash Health
2016
Monash University
2016
Singapore General Hospital
2011-2015
University of Glasgow
2010-2011
Acute ischemic stroke (AIS) is a known neurological complication in patients with respiratory symptoms of COVID-19 infection. However, AIS has not been described as late sequelae without COVID-19.To assess experienced by adults 50 years or younger the convalescent phase asymptomatic infection.This case series prospectively identified consecutive male who received care for from public health hospitals Singapore between May 21, 2020, and October 14, 2020. All these had laboratory-confirmed...
The coronavirus disease 2019 (COVID-19) is a zoonotic viral infection originating from Wuhan, China in December 2019. World Health Organization has classified this pandemic as global health emergency due to its virulent nature of transmission, which may lead acute respiratory distress syndrome. Singapore’s ministry responded with enhanced surveillance COVID-19 for all suspected pneumonia cases, further increasing the volume testing via real-time reverse transcription PCR, well samples...
Introduction: Pregnant women are reported to be at increased risk of severe coronavirus disease 2019 (COVID-19) due underlying immunosuppression during pregnancy. However, the clinical course COVID-19 in pregnancy and vertical horizontal transmission remain relatively unknown. We aim describe evaluate outcomes pregnant with Singapore. Methods: Prospective observational study 16 patients admitted for 4 tertiary hospitals Outcomes included disease, loss, transmission. Results: Of patients,...
Abstract GRP78/BiP is a key member of the molecular chaperone heat shock protein (Hsp) 70 family. It has critical role in prostate cancer (PC) including Pten loss‐driven carcinogenesis, but basis this remains unclear. We investigated effect GRP78 and its putative client proteins, androgen receptor (AR) clinical PC. Expression Hsp70–hsp90 proteins (HER2, HER3, AR AKT) were studied an incidence tissue microarray (TMA) cancer. The relationship was further tested vitro cell models (LNCaP derived...
Context.— The use of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serologic tests detects antibodies in the host, contributing to identification individuals who have been exposed disease 2019 (COVID-19). Objective.— To critically evaluate commercially available SARS-CoV-2 serology tests. Design.— A total 333 unique, nonduplicated serum samples obtained from COVID-19 patients (n = 170) and negative controls 163) before December were used study. Samples tested on Roche E411...
Three doses of SARS-CoV-2 mRNA vaccines have been recommended for cancer patients to reduce the risk severe disease. Anti-neoplastic treatment, such as chemotherapy, may affect long-term vaccine immunogenicity.Patients with solid or haematological were recruited from 2 hospitals between July 2021 and March 2022. Humoral response was evaluated using GenScript cPASS surrogate virus neutralisation assays. Clinical outcomes obtained medical records national mandatory-reporting databases.A total...
Article Parallel testing of 241 clinical nasopharyngeal swabs for the detection SARS-CoV-2 virus on Cepheid Xpert Xpress and Roche cobas assays was published February 1, 2021 in journal Clinical Chemistry Laboratory Medicine (CCLM) (volume 59, issue 2).
Coronavirus Disease 2019 (COVID-19) serology has an evolving role in the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, its use hospitalized patients with symptoms remains unclear. Hospitalized illness admitted to isolation ward were recruited. All had negative nasopharyngeal swab polymerase chain reaction (PCR) for SARS-CoV-2. Serological studies using four separate assays (cPass: surrogate neutralizing enzyme-linked immunosorbent assay...
Difficult and large common bile duct stones can be crushed removed using a mechanical lithotripter. Very often the lack of working space within causing failure lithotripsy would inevitably mean repeat or further invasive procedures.
Colonic atresia (CA) is an unusual cause of neonatal intestinal obstruction where a section the colon has failed to form, leading blockage or absence. A premature baby was delivered at 32 weeks gestation via caesarian following fetal distress. She grossly oedematous and diagnosed with severe fetalis hydrops secondary anaemia. resuscitated stabilized. On sixth day life, neonate's abdomen became severely distended bilious vomiting failure pass meconium. We suspected performed omnipaque enema...
Abstract Introduction The Z11 trial demonstrates that an axillary lymph node dissection (ALND) can be avoided in patients with low burden who undergo breast conserving surgery (BCS), combined whole-breast radiotherapy and systemic therapy. Our group propose a standardisation of sentinel biopsy (SLNB), incorporating 2 novel nodal stations (SNS) which represent sequential echelons SLN draining the – intercostalbrachial nerve (ICB) medial pectoral neurovascular bundle (MP). By increasing...
Abstract Background: Sentinel lymph node biopsy (SLNB) has been widely used in early breast cancer patients for the detection of axillary nodal metastasis. We were first to describe 2 novel sentinel stations (SNS) relation intercostobrachial nerve (ICB) and medial pectoral neurovascular bundle (MP) at which nodes (SLN) consistently identified, even only with use blue dye. In a pilot study involving 176 cases, we have shown that ICB MP SNS represent sequential echelons SLN draining breast. It...
PURPOSE: Topical Growth Factors are important future pillars in wound healing but have limited evidence based literature. Meta-analysis and systematic review on all growth factors was performed. METHODS: All human randomised control trials (RCTs) involving factor Pubmed, Ovid, Cochrane register non-randomised comparative retrospective analyses with large patient numbers were included for their statistical weight (n=51). Forest plots done. RESULTS: Five main groups identified: Platelet...
The pathogenesis of massive lower gastrointestinal bleed (LGIB) due to angio-dysplasia and ulceration is rare not well understood. We discuss an unusual presentation a child with painless LGIB arising from chronic intestinal adhesions causing subacute small bowel obstruction angio-dysplastic but without any clinical or radiological evidence obstruction.