A5081134776- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Urinary and Genital Oncology Studies
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Lipid Membrane Structure and Behavior
- Urologic and reproductive health conditions
- Fibroblast Growth Factor Research
- Urological Disorders and Treatments
- Cancer therapeutics and mechanisms
- Colorectal Cancer Screening and Detection
- Bone health and treatments
- Chromatin Remodeling and Cancer
- Melanoma and MAPK Pathways
- Urinary Bladder and Prostate Research
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Bone Metabolism and Diseases
- Inflammatory mediators and NSAID effects
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
University of Glasgow
2016-2025
Queen Elizabeth University Hospital
2017-2025
Khyber Teaching Hospital
2022-2024
Hôpital Maisonneuve-Rosemont
2024
Cancer Research UK Scotland Institute
2012-2023
King George's Medical University
2022-2023
Cleveland Clinic
2012-2023
Shaukat Khanum Memorial Cancer Hospital and Research Center
2023
Henry Ford Hospital
2023
Muhammad Nawaz Shareef University of Agriculture
2023
Robot-assisted radical cystectomy is being performed with increasing frequency, but it unclear whether total intracorporeal surgery improves recovery compared open for bladder cancer.
Androgen-deprivation therapy (ADT) is standard treatment for locally advanced or metastatic prostate cancer (PCa). Many patients develop castration resistance (castration-resistant PCa [CRPC]) after approximately 2-3 yr, with a poor prognosis. The molecular mechanisms underlying CRPC progression are unclear.
Significance Using an unbiased forward mutagenesis screen, we were able to successfully identify candidate genes that drive advanced and metastatic prostate cancer (CaP). Alterations of peroxisome proliferator-activated receptor gamma ( PPARG ), encoding a regulator crucial lipid metabolism, appear play role in the development CaP both humans mice.
Abstract Background Prostate cancer (PC) is the commonest male visceral cancer, and second leading cause of mortality in men Western world. Methods Using a forward-mutagenesis Sleeping Beauty (SB) transposon-based screen Probasin Cre-Recombinase ( Pb-Cre ) Pten -deficient mouse model PC, we identified Arid1a loss as driver development metastatic disease. Results The insertion transposon gene resulted 60% reduction expression, reduced tumour free survival SB:Pten fl/fl INT median 226 days vs...
The objective of this study was to determine variables that correlate with the survival patients extrapulmonary small cell carcinoma (EPSCC).Medical records 101 eligible EPSCC who were diagnosed in Saskatchewan from 1971 2002 reviewed. Survival calculated by using Kaplan-Meier method. A logistic regression analysis a backward elimination carried out prognostic predicted mortality.The median patient age 72 years (range, 24-100 years), and male-to-female ratio 1.4:1. primary disease sites as...
Concurrent activation of RAS/ERK and PI3K/AKT pathways is implicated in prostate cancer progression. The negative regulators these pathways, including sprouty2 (SPRY2), protein phosphatase 2A (PP2A), tensin homolog (PTEN), are commonly inactivated cancer. molecular basis cooperation between genetic alterations unknown. Here, we show that SPRY2 deficiency alone triggers AKT ERK, but this insufficient to drive tumorigenesis. In addition ERK activation, loss also activates a PP2A-dependent...
Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)–extracellular protein (ERK5)-mediated signalling has been implicated in a number of tumour types including prostate cancer (PCa). The molecular basis ERK5-driven carcinogenesis and its clinical relevance remain to be fully characterised. Modulation ERK5 expression or function human PCa PC3 PC3–ERK5 (stably transfected with ERK5) cells was performed using siRNA-mediated knockdown the MEK inhibitor PD18435 respectively. In vitro...
Abstract Peroxisome Proliferator-Activated Receptor Gamma (PPARG) is one of the three members PPAR family transcription factors. Besides its roles in adipocyte differentiation and lipid metabolism, we recently demonstrated an association between PPARG metastasis prostate cancer. In this study a functional effect on AKT serine/threonine kinase 3 (AKT3), which ultimately results more aggressive disease phenotype was identified. AKT3 has previously been shown to regulate co-activator 1 alpha...
Abstract Background Phoenix dactylifera L. has a diverse set of pharmacological properties due to its distinct phytochemical profile. The purpose this study was investigate the anticancer potential seed extract (PDSE) in human breast cancer MDA-MB-231 and MCF-7 cells, as well liver HepG2 efficacy triple-negative followed by silico validation molecular interaction between active components PDSE caspase-3, an apoptosis executioner protein . Methods In study, cell lines were cultured...
Noncompliance with evidence-based interventions and guidelines contributes to significant variable recurrence progression in patients non-muscle-invasive bladder cancer (NMIBC). The implementation of a quality performance indicator (QPI) programme Scotland's National Health Service (NHS) aimed improve outcomes reduce nationwide variance.
Raf-1, a protein serine-threonine kinase, plays critical role in mitogen-activated kinase (MKK/MEK)- (extracellular signal-regulated kinase) (MAPK/ERK) pathways. We show here that systemically delivered novel cationic cardiolipin liposomes (NeoPhectin-AT) containing small interfering RNA (siRNA) against Raf-1 silence the expression of tumor tissues and inhibit growth xenograft model human prostate cancer. The knockdown by siRNA is also associated with down-regulation cyclin D1 vivo.
SCC-S2/GG2-1/NDED (approved gene symbol TNFAIP8) is a transcription factor NF-κB-inducible, antiapoptotic, and oncogenic molecule. In this study, we examined the role of SCC-S2 in invasion experimental metastasis. We demonstrate that expression cDNA MDA-MB 435 human breast cancer cells associated with enhanced vitro increased frequency pulmonary colonization tumor athymic mice. Systemic treatment mice cationic liposomal formulation antisense oligo led to decreased incidence metastasis...
Arterial spin labelling (ASL) has proved to be a promising magnetic resonance imaging (MRI) technique measure brain perfusion. In this study, volumetric three-dimensional (3D) gradient and echo (GRASE) ASL was used produce cerebral blood flow (CBF) arterial arrival time (AAT) maps during rest an infusion of remifentanil. Gradient perfusion-weighted images were collected at multiple inflow times (500 2,500 ms in increments 250 ms) accurately fit perfusion model. Fit estimates assessed using...
Endoxifen is an active metabolite of tamoxifen, a drug used in the treatment breast cancer. In order to be clinically effective, tamoxifen must converted endoxifen by cytochrome P450 2D6 (CYP2D6). A study involving single escalating oral doses was conducted humans evaluate safety, tolerability, and pharmacokinetics (PK) endoxifen. This first demonstrating that are safe well tolerated have sufficient bioavailability reach systemically effective levels human subjects. Furthermore, it found...
Mutations in the Ras family of proteins (predominantly H-Ras) occur approximately 40% urothelial cell carcinoma (UCC). However, relatively little is known about subsequent mutations/pathway alterations that allow tumour progression. Indeed, expressing mutant H-Ras within mouse bladder does not lead to formation, unless this expressed at high levels. The Wnt signalling pathway deregulated 25% UCC, so we examined if correlated with activation MAPK human UCC and found a significant correlation....
Prostate cancer (CaP) is the most common among adult men in Western world. Better insight into its tumor-activating pathways may facilitate development of targeted therapies. In this study, we show that patients who develop prostate tumors with low levels PTEN and high HER2/3 have a poor prognosis. This functionally relevant, as targeting Her2 activation to murine cooperates Pten loss drives CaP progression. Mechanistically, associated MAPK pathway abrogation loss-induced cellular senescence...