A5100667656- Phytochemicals and Medicinal Plants
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Diverse Scientific Research Studies
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Natural Antidiabetic Agents Studies
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Curcumin's Biomedical Applications
- Medicinal Plants and Neuroprotection
- Date Palm Research Studies
- Insect Pest Control Strategies
- Essential Oils and Antimicrobial Activity
- Inflammasome and immune disorders
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- Insect Resistance and Genetics
- Heme Oxygenase-1 and Carbon Monoxide
- Ethnobotanical and Medicinal Plants Studies
- Nigella sativa pharmacological applications
- Synthesis and biological activity
- Long-Term Effects of COVID-19
- Pharmacological Receptor Mechanisms and Effects
- Eicosanoids and Hypertension Pharmacology
Era's Lucknow Medical College and Hospital
2014-2024
North Dakota State University
2024
Virginia Tech
2024
New Era University
2022
University of Engineering and Technology Taxila
2016-2021
Bristol Royal Hospital for Children
2018
Health Education England
2018
King's College London
2015
University of Chicago
2006-2009
University of South Florida
2007
Ischemia–reperfusion (I/R) injury is a disease process that affects several vital organs. There widespread agreement the NLRP3 inflammasome pathway plays crucial role in development of I/R injury. We have developed transferrin-conjugated, pH-responsive nanomicelles for entrapment MCC950 drug. These specifically bind to transferrin receptor 1 (TFR1) expressed on cells blood–brain barrier (BBB) and thus help cargo cross BBB. Furthermore, therapeutic potential was assessed using vitro, ovo,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel etiological agent of disease 2019 (COVID-19). Nigella sativa, commonly known as black seed or cumin, has been historical and traditional plant since thousands years. Based on their therapeutic efficacy, the chief components terpenoids flavonoids were selected from N. sativa seeds oil. This study was designed to check antiviral efficacy main phytoconstituents against five potential targets SARS-CoV-2 using in silico...
Abstract Background Phoenix dactylifera L. has a diverse set of pharmacological properties due to its distinct phytochemical profile. The purpose this study was investigate the anticancer potential seed extract (PDSE) in human breast cancer MDA-MB-231 and MCF-7 cells, as well liver HepG2 efficacy triple-negative followed by silico validation molecular interaction between active components PDSE caspase-3, an apoptosis executioner protein . Methods In study, cell lines were cultured...
Ischemic stroke involves pro-inflammatory species, which implicates inflammation in the disease mechanism. Recent studies indicate that prevalence of therapeutic choice such as stem cell transplantation has seen an upsurge ischemic stroke. However, after fate transplanted cells is largely unknown. Human mesenchymal (MSCs), due to their robust survival rate upon brain tissue, are being widely employed treat In present study, we have evaluated naringenin-loaded gelatin-coated polycaprolactone...
Abstract Ajwa dates ( Phoenix dactylifera L.) are used by traditional therapeutic practitioners for several health benefits but most remain to be scientifically validated. In this study, we evaluated the apoptosis-inducing effect of ethanolic extract date pulp (ADP) on human hepatocellular carcinoma (HCC) HepG2 cells. High performance liquid chromatography analysis revealed presence polysaccharide β-D-glucan in ADP extract. Treated HCC cells morphological characteristics apoptosis under...
Abstract Recently, a new and fatal strain of coronavirus named as SARS-CoV-2 (Disease: COVID-19) appeared in Wuhan, China December 2019. Due to its fast growing human transmission confirmed cases nearly every country, it has been declared pandemic by World Health Organisation (WHO) on 11 March 2020. Till now, there is no therapy such vaccines specific therapeutic agents available globally. Inspite this, some protease inhibitors antiviral namely lopinavir, ritonavir, remdisivir chloroquine...
Abstract Ajwa dates ( Phoenix dactylifera L.) have been described in traditional and alternative medicine to provide several health benefits, but their mechanism of apoptosis induction against human triple-negative breast cancer MDA-MB-231 cells remains be investigated. In this study, we analyzed the phytoconstituents ethanolic Dates Pulp Extract (ADPE) by liquid chromatography-mass spectrometry (LC–MS) investigated anticancer effects cells. LC–MS analysis revealed that ADPE contained...
Stem cell therapies have emerged as a promising treatment strategy for various diseases characterized by ischemic injury such stroke. Cell survival after transplantation remains critical issue. We investigated the impact of oxidative stress, being typically present in ischemically challenged tissue, on human dental pulp stem cells (hDPSC) and mesenchymal (hMSC). used oxygen-glucose deprivation (OGD) to induce stress hDPSC hMSC. OGD-induced generation O2•- or H2O2 enhanced autophagy inducing...
Intense cancer research is underway to discover possible therapies but no major breakthrough appears be in sight terms of its cure when diagnosed late. The cytostatic and growth inhibitory effect high pressure on cells well documented. In the present study, two cell lines viz . MDA-MB-231 (breast carcinoma) A549 (lung one normal line (Vero) were subjected increased 18 psi a specially constructed chamber. It was found that induced significant change parameters both versus cells. Exposure...
The genus Withania (Family: Solanaceae) holds an important position in Ayurveda, the Indian traditional system of medicine. somnifera Dunal and coagulans have been documented folklore as panaceas for various ailments since time immemorial. W. (WC), commonly called cheese maker is used fermenting milk production parts India.In study, vitro cytotoxicity methanolic extract dried fruits (berries) WC was evaluated a dose dependent manner using trypan blue dye exclusion method against human breast...
A sudden outbreak of a novel coronavirus SARS-CoV-2 in 2019 has now emerged as pandemic threatening to efface the existence mankind. In absence any valid and appropriate vaccines combat this newly evolved agent, there is need resource molecules for treatment prophylaxis. To effect, flavonol morin which found fruits, vegetables various medicinal herbs been evaluated its antiviral potential present study. PASS analysis versus reference drugs baricitinib, remdesivir hydroxychloroquine revealed...
Regulatory bodies are nowadays concerned with pharmaceutical drug products' safety, efficacy, and quality. Quality is the priority of all regulatory bodies, it a high for triple P factor (patient, pharmacist, physician). It links industries authorities designing, manufacturing, consistently delivering safe efficient products. mainly focuses on fabricating designing formulations manufacturing processes to ensure predefined product based ICH Guidelines Q8 development, Q9 quality risk...
Ischemia–reperfusion (I/R)-related disorders, such as stroke, myocardial infarction, and peripheral vascular disease, areamongst the most frequent causes of disease death. Tissue injury or death may result from initial ischemic insult, primarily determined by magnitude duration interruption in blood supplyand then subsequent reperfusion-induced damage.Various vitro vivo models are currently available to study I/R mechanism brain other tissues. However, thus far, no ovo model has been...