A5062466537- Phytochemicals and Medicinal Plants
- Computational Drug Discovery Methods
- Diverse Scientific Research Studies
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- Toxin Mechanisms and Immunotoxins
- COVID-19 Clinical Research Studies
- Insect Pest Control Strategies
- Moringa oleifera research and applications
- Phytochemistry and Biological Activities
- Nigella sativa pharmacological applications
- Natural Antidiabetic Agents Studies
- Ethnobotanical and Medicinal Plants Studies
- Curcumin's Biomedical Applications
- Natural Compound Pharmacology Studies
- Biomarkers in Disease Mechanisms
- Phytochemistry Medicinal Plant Applications
- Medicinal Plants and Neuroprotection
- Transgenic Plants and Applications
- Cancer Research and Treatment
- PARP inhibition in cancer therapy
- Date Palm Research Studies
- Dermatology and Skin Diseases
Era's Lucknow Medical College and Hospital
2014-2024
Integral University
2023
University of Lucknow
2023
National Botanical Research Institute
2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel etiological agent of disease 2019 (COVID-19). Nigella sativa, commonly known as black seed or cumin, has been historical and traditional plant since thousands years. Based on their therapeutic efficacy, the chief components terpenoids flavonoids were selected from N. sativa seeds oil. This study was designed to check antiviral efficacy main phytoconstituents against five potential targets SARS-CoV-2 using in silico...
Abstract Background Phoenix dactylifera L. has a diverse set of pharmacological properties due to its distinct phytochemical profile. The purpose this study was investigate the anticancer potential seed extract (PDSE) in human breast cancer MDA-MB-231 and MCF-7 cells, as well liver HepG2 efficacy triple-negative followed by silico validation molecular interaction between active components PDSE caspase-3, an apoptosis executioner protein . Methods In study, cell lines were cultured...
SARS-CoV-2 has been responsible for causing 6,218,308 deaths globally till date and garnered worldwide attention. The lack of effective preventive therapeutic drugs against further worsened the scenario bolstered research in area. N-terminal C-terminal RNA binding domains (NTD CTD) nucleocapsid protein represent attractive drug targets. Naturally occurring compounds are an excellent source novel candidates due to their structural diversity safety. Ten major bioactive were identified...
A sudden outbreak of a novel coronavirus SARS-CoV-2 in 2019 has now emerged as pandemic threatening to efface the existence mankind. In absence any valid and appropriate vaccines combat this newly evolved agent, there is need resource molecules for treatment prophylaxis. To effect, flavonol morin which found fruits, vegetables various medicinal herbs been evaluated its antiviral potential present study. PASS analysis versus reference drugs baricitinib, remdesivir hydroxychloroquine revealed...
Therapeutic drugs based on natural products for the treatment of SARS-CoV-2 are currently unavailable. This study was conducted to develop an anti-SARS-CoV-2 herbal medicine face urgent need COVID-19 treatment. The bioactive components from ethanolic extract Moringa oleifera fruits (MOFs) were determined by gas chromatography-mass spectroscopy (GC-MS). Molecular-docking analyses elucidated binding effects identified phytocomponents against spike glycoprotein (PDB ID: 6VYB) and human ACE2...
There is currently a dearth of specific therapies to treat respiratory infections caused by the three related species coronaviruses viz. SARS-CoV-2, SARS-CoV and MERS-CoV. Prevention from disease safest most convenient alternative available. The present study aimed evaluate preventive therapeutic effect fifteen phytoconstituents medicinal plants Ayurveda against in silico screening. All exhibited rapid GI absorption bioavailability them had no toxicity versus reference drug chloroquine. BAS...
Myricetin (Myr) and Bergapten (Ber) are two potential anticancer flavonoids.The current study aimed to find out whether the flavonoids Myr Ber have breast cancer-preventive therapeutic potential.Myr separately showed an IC 50 of µM against MDA-MB-231 (breast cancer) cells while having no discernible impact on normal HEK-293 cells.When compared untreated cells, significantly increased production free radicals, induced chromatin condensation, early late apoptosis in at respective doses (50...
The acidic environment due to excessive glycolytic activity and poor perfusion promote the cancerous cell growth. This condition also decreases efficiency of chemotherapeutic drugs. present study investigates whether alkalinity increment media can reduce growth improve effect drugs in-vitro. For this experiment, vero cells were control whereas MDA-MB IM experimental cells. alkaline pH reduces up 18% 42%, but exact mechanism is not known with certainty.
Sperm is a vital component of the body because it used for reproduction, process creation next generation. Male infertility can cause inability to reach conception, be due defect in semen parameters, anatomical defects reproductive tract, hormonal issues, etc. A sperm count below 15 million sperm/mL considered state oligozoospermia. Ksheenashukra situation which both quantity and quality shukra dhatu are reduced. Oligozoospermia synonymous with Ksheenashukra, one eight varieties shukradushti...
Abstract Objectives Garcinia indica (commonly known as kokum) has been employed in Ayurvedic and Siddha medicine since ancient times. Every part of the plant its own set advantages applications. Therefore, present evaluates phytochemical composition biological activity spectrum ethanolic fruit extract G. indica. Methods Ethanolic fruits (GIFEE) underwent TPC TFC quantification, with bioactive components characterized via GC-MS HPLC. The disc diffusion method was used for assessing...
Chemoresistance is one of the biggest hurdles while treating cancer clinically. Due to its heterogeneous nature, complications chemoresistance mechanisms breast cannot be completely elucidated. Existing main-line drug treatment can slow down process malignancy with part and parcel called resistance. The combinatorial effect several chemotherapeutic drugs, targeting different pathways at same time, work efficiently, yet toxicity drug-drug interaction remain intact. To overcome this hurdle, a...
Abstract Prevention from disease is presently the cornerstone of fight against COVID-19. With rapid emergence novel variants SARS-CoV-2 viz . B.1.1.7 (UK), B.1.351 (South Africa), P.1 (Brazil), delta variant B.1.617.2 (India) and recently emerged Omicron B.1.1.529 there an urgent need for prophylactic agents that have ability to strengthen fortify immune system. To this effect, Withania somnifera (WS) its phytoconstituent(s) immense untapped immunomodulatory therapeutic potential. The in...
In the present study was to determine anti-inflammatory activity of aqueous extract bark and root Myrica esculenta their active phytoconstituents through in vitro silico studies. The bioactive phytoconstituent determined by GC-MS spectroscopy techniques. After that, total phenolic flavonoid content both determined. Furthermore, extracts. molecular docking analysis binding affinity compounds against inflammatory proteins such as COX-1, COX-2, IL-10, TNF-α. revealed that has highest compared...
Background: In recent years, great progress has been made in reducing the high level of malaria suffering worldwide. There is a need to evaluate drug resistance reversers and consider new medicines against malaria. are many approaches development antimalarial drugs. Specific concerns must be taken into account these approaches, particular requirement for inexpensive simple therapies limit discovery expenses. Important ongoing efforts optimisation treatment with available medications,...