A5009890932- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Prostate Cancer Treatment and Research
- Surgical Simulation and Training
- Urinary and Genital Oncology Studies
- Anatomy and Medical Technology
- Urinary Bladder and Prostate Research
- Cardiac, Anesthesia and Surgical Outcomes
- Urologic and reproductive health conditions
- Innovations in Medical Education
- Dental Education, Practice, Research
- Pelvic floor disorders treatments
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
- Genital Health and Disease
- Clinical practice guidelines implementation
- Advanced Radiotherapy Techniques
- Abdominal Surgery and Complications
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
- Renal and Vascular Pathologies
- Non-Invasive Vital Sign Monitoring
- Cancer Mechanisms and Therapy
University College London Hospitals NHS Foundation Trust
2016-2024
University College London
2015-2024
University College Hospital
2013-2024
Sri Ramachandra Institute of Higher Education and Research
2023-2024
Neurological Surgery
2023
Royal London Hospital
2017-2022
University College Hospital at Westmoreland Street
2017-2022
University of Edinburgh
2021
University of Leeds
2021
Torbay Hospital
2021
Robot-assisted radical cystectomy is being performed with increasing frequency, but it unclear whether total intracorporeal surgery improves recovery compared open for bladder cancer.
Automatically recognising surgical gestures from data is an important building block of automated activity recognition and analytics, technical skill assessment, intra-operative assistance eventually robotic automation. The complexity articulated instrument trajectories the inherent variability due to style patient anatomy make analysis fine-grained segmentation motion patterns robot kinematics alone very difficult. Surgical video provides crucial information site with context for kinematic...
To assess the cumulative effect of an enhanced recovery after surgery (ERAS) pathway and minimally invasive robot-assisted radical cystectomy with intracorporeal urinary diversion (iRARC) in comparison open (ORC) on length hospital stay (LOS) peri-operative outcomes.Between February 2009 October 2017, 304 cases were performed at a single institution (ORC, n = 54; [RARC], 250). Data prospectively collected. We identified 45 consecutive ORC without ERAS before commencement RARC programme...
Objective To describe a robot-assisted intracorporeal pyramid neobladder reconstruction technique and report operative perioperative metrics, postoperative upper tract imaging, functional outcomes, oncological outcomes. Patients Methods In all, 20 patients (19 male one female) with mean (sd; range) age of 57.2 (12.4; 31.0–78.2) years underwent radical cystectomy (RARC). Most cases were ≤pT1 (17 patients) the remaining three had muscle-invasive bladder cancer (MIBC) at RARC histopathology....
The utilisation of robot-assisted radical cystectomy with intracorporeal reconstruction (iRARC) has increased in recent years. Little is known about the length learning curve (LC) for this procedure.To study LC iRARC terms 90-d major complications (MC90; Clavien-Dindo grade ≥3), overall (OC90, grades 1-5), operating time (OT), estimated blood loss (EBL), and hospital stay (LOS).This was a retrospective analysis all consecutive cases from nine European high-volume hospitals ≥100 cases. All...
Objectives To test the feasibility of randomisation to radical prostatectomy (RP) plus pelvic lymphadenectomy in addition standard‐of‐care (SOC) systemic therapy men with newly diagnosed oligo‐metastatic prostate cancer. Patients and Methods A prospective, randomised, non‐blinded, clinical trial an embedded QuinteT Recruitment Intervention (QRI) optimise recruitment was conducted nine nationwide tertiary care centres undertaking high‐volume robotic surgery. We aimed randomise 50 synchronous...
Background: The accuracy of multi-parametric MRI (mpMRI) in the pre-operative staging prostate cancer (PCa) remains controversial. Objective: purpose this study was to evaluate ability mpMRI accurately predict PCa extra-prostatic extension (EPE) on a side-specific basis using risk-stratified 5-point Likert scale. This also aimed assess influence scan quality diagnostic accuracy. Patients and Methods: We included 124 men who underwent robot-assisted RP (RARP) as part NeuroSAFE PROOF at our...
This article describes apparatus to aid histological validation of magnetic resonance imaging studies the human prostate. The includes a 3D-printed patient-specific mold that facilitates aligned in vivo and ex imaging, in-situ tissue fixation, sectioning with minimal organ deformation. dedicated container include MRI-visible landmarks enable consistent positioning minimize image registration complexity. inclusion high spatial resolution aids MRI histopathology data.
The VERDICT framework for modelling diffusion MRI data aims to relate parameters from a biophysical model histological features used tumour grading in prostate cancer. Validation of the is necessary clinical use. This study compared obtained ex vivo with histology five specimens radical prostatectomy. A patient‐specific 3D‐printed mould was investigate effects fixation on and aid registration histology. rich set acquired each before after fixation. At both time points, were best described by...
The ERG oncogene, a member of the ETS family transcription factor encoding genes, is genetic driver prostate cancer. It activated through fusion with androgen-responsive TMPRSS2 promoter in 50% cases. There therefore significant interest developing novel therapeutic agents that target ERG. We have taken an antisense approach and designed morpholino-based oligonucleotides by inducing skipping its constitutive exon 4.We morpholino (splice-switching oligonucleotides, SSOs) both 5' 3' splice...