A5061822272- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Digital Radiography and Breast Imaging
- AI in cancer detection
- Medical Imaging Techniques and Applications
- Global Cancer Incidence and Screening
- Radiation Dose and Imaging
- Osteoarthritis Treatment and Mechanisms
- Cutaneous Melanoma Detection and Management
- Advanced X-ray and CT Imaging
- Cerebrovascular and Carotid Artery Diseases
- Molecular Biology Techniques and Applications
- Prostate Cancer Treatment and Research
- Biomedical and Engineering Education
- Inflammatory mediators and NSAID effects
- Medical Imaging and Analysis
- Statistical Methods and Inference
- Urologic and reproductive health conditions
- Cell Adhesion Molecules Research
- Image and Signal Denoising Methods
- ATP Synthase and ATPases Research
- Breast Cancer Treatment Studies
The University of Sydney
2013-2023
University of Chicago
2018
Royal Prince Alfred Hospital
2012-2015
Resonance Health (Australia)
2004-2006
Royal North Shore Hospital
2003-2005
Sydney Adventist Hospital
2003
Resonance Research (United States)
2001
Western University
1997
University of Sheffield
1994
Shriners Hospitals for Children - Canada
1994
We demonstrate the direct involvement of increased collagenase activity in cleavage type II collagen osteoarthritic human femoral condylar cartilage by developing and using antibodies reactive to carboxy-terminal (COL2-3/4C(short)) amino-terminal (COL2-1/4N1) neoepitopes generated native matrix metalloproteinase (MMP)-1 (collagenase-1), MMP-8 (collagenase-2), MMP-13 (collagenase-3). A secondary followed initial produced these recombinant collagenases. This neoepitope COL2-1/4N2. There was...
A new immunoassay was developed to detect denaturation of type II collagen in osteoarthritis (OA). peptide, alpha 1 (II)-CB11B, located the CB11 peptide collagen, synthesized and used produce a monoclonal antibody (COL2-3/4m) IgG1 (kappa) isotype. This reacts with defined epitope denatured but not native 3 chain XI collagen. The latter is present very small amounts (about 1% wt/wt) cartilage relative (II) chain. By using an enzyme-linked immunosorbent assay, total content were determined....
Enhanced denaturation of type II collagen fibrils in femoral condylar cartilage osteoarthritis (OA) has recently been quantitated immunochemically (Hollander, A.P., T.F. Heathfield, C. Webber, Y. Iwata, R. Bourne, Rorabeck, and A.R. Poole. 1994. J. Clin. Invest. 93:1722-1732). Using the same antibody that only reacts with denatured collagen, we investigated immunoperoxidase histochemistry (results were graded for analysis) sites (loss triple helix) this molecule human aging (at autopsy, n=...
To investigate the hypothesis that clinically observed decrease in apparent diffusion coefficient (ADC) at diffusion-weighted magnetic resonance imaging with increasing prostate cancer Gleason grade can be attributed to an volume of low-diffusivity epithelial cells and corresponding decreasing volumes higher-diffusivity stroma lumen space rather than increased cell density.Tissue samples were acquired after institutional ethics review committee approval informed consent from patients...
Purpose To evaluate whether compartmental analysis by using hybrid multidimensional magnetic resonance (MR) imaging can be used to diagnose prostate cancer and determine its aggressiveness. Materials Methods Twenty-two patients with underwent preoperative 3.0-T MR imaging. Axial images were obtained all combinations of echo times (47, 75, 100 msec) b values 0, 750, 1500 sec/mm2, resulting in a 3 × array data associated each voxel. Volumes the tissue components stroma, epithelium, lumen...
Purpose To explore relationships between reader performance and characteristics in mammography for specific radiologist groupings on the basis of annual number readings. Materials Methods The institutional review board approved study waived need patient consent to use all images. Readers gave informed consent. One hundred sixteen radiologists independently reviewed 60 mammographic cases: 20 cases with cancer 40 normal findings. located any visualized cancer, levels confidence were scored...
Abstract Background Therapeutic mammaplasty (TM) may be an alternative to mastectomy, but few well designed studies have evaluated the success of this approach or compared short-term outcomes TM with mastectomy without immediate breast reconstruction (IBR). Data from national iBRA-2 and TeaM were combined compare safety IBR. Methods The subgroup patients in study who underwent avoid identified, data on demographics, complications, oncology adjuvant treatment those undergoing IBR study....
Background Tissue estimates obtained by using microstructure imaging techniques, such as hybrid multidimensional (HM) MRI, may improve prostate cancer diagnosis but require histologic validation. Purpose To validate tissue composition measured HM with quantitative evaluation from whole-mount prostatectomy the reference standard. Materials and Methods In this HIPAA-compliant study, December 2016 to July 2018, prospective participants biopsy-confirmed underwent 3-T MRI before radical...
Magnetic resonance (MR) spectroscopy is a noninvasive technique that can be used to detect and measure the concentration of metabolites neurotransmitters in brain other organs. We vivo (1)H MR subjects with low back pain compared control alterations biochemistry three regions associated processing. A pattern recognition approach was determine whether it possible discriminate accurately from based on spectroscopy. spectra were obtained prefrontal cortex, anterior cingulate thalamus 32 33...
Diffusion tensor microimaging was used to investigate the water diffusion properties of formalin-fixed prostate tissue at spatial resolution approaching cellular scale. performed 16.4 T with 40 μm isotropic voxels. clearly demonstrated distinct microscopic environments and architecture consistent that seen on light microscopy same tissue. The most restricted environment is secretory epithelial cell layer (voxel bulk mean diffusivity, D = 0.4 ± 0.1 × 10(-3) mm(2)/sec). in fibromuscular...
Purpose To compare the theoretical information content of four popular models diffusion‐weighted signal attenuation. Method Four whole prostates were imaged fresh unfixed and fixed at 9.4T. Biexponential, kurtosis, stretched exponential, monoexponential ranked using Akaike's Information Criterion (AIC) with validation by a leave‐one‐out test model prediction error. Results For tissue measurements ( b ‐value range: 17–2104 s/mm 2 ) biexponential kurtosis had similar to each other this was...
This article describes apparatus to aid histological validation of magnetic resonance imaging studies the human prostate. The includes a 3D-printed patient-specific mold that facilitates aligned in vivo and ex imaging, in-situ tissue fixation, sectioning with minimal organ deformation. dedicated container include MRI-visible landmarks enable consistent positioning minimize image registration complexity. inclusion high spatial resolution aids MRI histopathology data.
The VERDICT framework for modelling diffusion MRI data aims to relate parameters from a biophysical model histological features used tumour grading in prostate cancer. Validation of the is necessary clinical use. This study compared obtained ex vivo with histology five specimens radical prostatectomy. A patient‐specific 3D‐printed mould was investigate effects fixation on and aid registration histology. rich set acquired each before after fixation. At both time points, were best described by...
Oligonucleotide probes based on the N‐terminal amino acid sequences of NqrA and NqrC subunits were used to clone genes for Na + ‐dependent NADH‐ubiquinone oxidoreductase complex from Vibrio alginolyticus . Four consecutive ORFs identified encoding subunit proteins 48.6, 46.8, 27.7 22.6 kDa, respectively (NqrA—D). A further ORF, showing 71% homology BolA protein Escherichia coli , was located upstream. From sequence comparisons, we conclude that V. is clearly distinct corresponding H enzymes...
Abstract MR microimaging at 16.4 T with 40‐μm isotropic voxels was used to investigate compartmentation of water diffusion in formalin‐fixed prostate tissue. Ten tissue samples (∼ 28 mm 3 each) from five organs were imaged. The mean diffusivity epithelial, stromal, and ductal/acinar compartments estimated by two methods: ( 1 ) manual region interest selection 2 Gaussian fitting voxel histograms. For the interest‐method, means sample compartment diffusivities significantly different P <...
This study investigates the hypothesis that shallow edge lifting force in high-level rock climbers is more strongly related to fingertip soft tissue anatomy than absolute strength or body mass ratio. Fifteen experienced performed repeated maximal single hand exercises on rectangular sandstone edges of depth 2.8, 4.3, 5.8, 7.3, and 12.5 mm while standing a measurement platform. Fingertip dimensions were assessed by ultrasound imaging. Shallow (2.8 4.3 mm) force, newtons normalized, was...
We investigated why some prostate cancers (PCas) are not identified on multiparametric MRI (mpMRI) by using ground truth reference from whole-mount prostatectomy specimens. A total of 61 patients with biopsy-confirmed PCa underwent 3T mpMRI followed prostatectomy. Lesions visible prospectively or retrospectively after correlating histology were considered “identified cancers” (ICs). that could be “unidentified (UCs). Pathologists marked the Gleason score, stage, size, and density cancer...