A5048195032- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Plant tissue culture and regeneration
- Plant nutrient uptake and metabolism
- Plant Physiology and Cultivation Studies
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Plant Molecular Biology Research
- Plant responses to water stress
- Postharvest Quality and Shelf Life Management
- Legume Nitrogen Fixing Symbiosis
- Melanoma and MAPK Pathways
- Circular RNAs in diseases
- Mass Spectrometry Techniques and Applications
- Turfgrass Adaptation and Management
- Wnt/β-catenin signaling in development and cancer
- Plant Ecology and Taxonomy Studies
- Microplastics and Plastic Pollution
- Organizational Learning and Leadership
- Plant Reproductive Biology
- Plant Micronutrient Interactions and Effects
- Glycosylation and Glycoproteins Research
Shandong Agricultural University
2013-2024
Institute of Botany
2020-2024
Beijing Health Vocational College
2024
University of Exeter
2019-2023
The Seventh Affiliated Hospital of Sun Yat-sen University
2022
Sun Yat-sen University
2022
Hubei University of Science and Technology
2021
Xiangya Hospital Central South University
2018
Central South University
2018
National Institute of Advanced Industrial Science and Technology
2018
Most in vitro studies experimental skin biology have been done 2-dimensional (2D) monocultures, while accumulating evidence suggests that cells behave differently when they are grown within a 3D extra-cellular matrix and also interact with other (1-5). Mouse models broadly utilized to study tissue morphogenesis vivo. However mouse human significant differences cellular architecture physiology, which makes it difficult extrapolate humans. Since melanocytes mostly localized hair follicles,...
Prostate is the most frequent cancer in men. progression driven by androgen steroid hormones, and delayed deprivation therapy (ADT). Androgens control transcription stimulating receptor (AR) activity, yet also pre-mRNA splicing through less clear mechanisms. Here we find androgens regulate AR-mediated transcriptional of epithelial-specific regulator ESRP2. Both ESRP2 its close paralog ESRP1 are highly expressed primary prostate cancer. Androgen stimulation induces switches many endogenous...
Abstract Dysregulation of alternative splicing is a feature cancer, both in aetiology and progression. It occurs because mutations splice sites or that regulate splicing, the altered expression activity factors factor kinases activity. Recently CDC2-like (CLKs) have attracted attention due to their increasing involvement cancer. We measured effect CLK inhibitor, benzothiazole TG003, on two prostate cancer cell lines. TG003 reduced proliferation increased apoptosis PC3 DU145 cells....
microRNAs (miRs) have recently emerged as small non-coding regulators of gene expression. We performed a loss-of-function screening by recruiting retrovirus mediated arbitrary manipulation genome coupled with escape cells from 5-Aza-2'-deoxycytidine (5-Aza-dC)-induced senescence. miRNA pool that 5-Aza-dC-induced senescence was subjected to miR-microarray analysis respect the untreated control. identified miR-451 one upregulated miRs and characterized its functional relevance drug resistance,...
The ERG oncogene, a member of the ETS family transcription factor encoding genes, is genetic driver prostate cancer. It activated through fusion with androgen-responsive TMPRSS2 promoter in 50% cases. There therefore significant interest developing novel therapeutic agents that target ERG. We have taken an antisense approach and designed morpholino-based oligonucleotides by inducing skipping its constitutive exon 4.We morpholino (splice-switching oligonucleotides, SSOs) both 5' 3' splice...
// Batool Shannan 1, 2 , Andrea Watters 1 Quan Chen Stefan Mollin 3 Markus Dörr Eric Meggers Xiaowei Xu 4 Phyllis A. Gimotty 5 Michela Perego Ling Li Joseph Benci Clemens Krepler Patricia Brafford Jie Zhang 6 Zhi Wei Gao Qin Liu Xiangfan Yin Katherine L. Nathanson Meenhard Herlyn * Adina Vultur Program of Cellular and Molecular Oncogenesis, Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA Department Dermatology, University Hospital Essen, Germany Chemistry, Marburg,...
Nitrogen (N) is an essential macronutrient that significantly affects turf quality. Commercial cultivars of bermudagrass (Cynodon dactylon (L.) Pers.) require large amounts nitrogenous fertilizer. Wild germplasm from natural habitats with poor nutrition and diverse N distributions important source for low-N-tolerant cultivated breeding. However, the mechanisms underlying differences in utilization among wild resources are not clear.To clarify low tolerance mechanism germplasm, growth,...
Melanoma is one of the most aggressive skin cancers and a major cause cancer-linked deaths worldwide. As morbidity mortality melanoma are increasing, it necessary to elucidate potential mechanism influencing progression. Tumor tissues adjacent normal (5 cm away from tumors) 22 patients at I-II stage 39 III-VI were acquired. The expression LINC01063 in was estimated by quantitative PCR. Functional assays employed investigate function melanoma. Mechanism adopted explore LINC01063. knockdown...
This study was designed to investigate the relationship between caloric value and salt tolerance of two varieties Miscanthus sacchariflorus (Amur silvergrass: M127 M022). The capacity, photosynthetic characteristics, Na+ K+ uptake by roots aboveground parts, different parts were obtained under hydroponic conditions. results showed that M022 more tolerant stress than former had a higher efficiency as well lower accumulation, efflux, larger K+/Na+ ratio. calorific values stems, spear leaves,...
High temperature stress (HT) is efficient in breaking endo-dormancy of perennial trees. The effects HT (50°C) on the respiration dormant nectarine (Prunus persica var. nectariana cv. Shuguang) vegetative buds were evaluated research. We found that bud was transiently inhibited by and pentose phosphate pathway (PPP) cytochrome C (CYT) significantly affected. On substrate level, PPP activated HT-treated compared with control group. However, activation did mot occur until hours after treatment....
Research in the area of hallmarks cancer has opened possibility designing new therapies based on modulating these properties. We present here a screen designed to find chemicals that modulate epithelial-mesenchymal transitions (EMTs) prostate cancer. For screening, we used repurposing library and, as readout, an FGFR2-based splicing reporter, which been shown previously be sensor for EMTs. Various properties cells were assessed, signaling pathways investigated, and vivo experiments nude mice...
Abstract Alternative splicing of the vascular endothelial growth factor A ( VEGF-A ) terminal exon generates two protein families with differing functions. Pro-angiogenic xxx a isoforms are produced via selection proximal 3′ splice site exon. Use an alternative distal anti-angiogenic b proteins. bichromatic splicing-sensitive reporter was designed to mimic and used as molecular tool further investigate this event. Part VEGF-A’s preceding intron were inserted into minigene construct followed...
Wilms tumour (WT), an embryonal kidney cancer, has been extensively characterised for genetic and epigenetic alterations, but a proportion of WTs still lack identifiable abnormalities. To uncover DNA methylation changes critical WT pathogenesis, we compared the epigenome foetal with two cell lines, filtering our results to remove common cancer‐associated enrich genes involved in early development. This identified four hypermethylated genes, which ESRP2 (epithelial splicing regulatory protein...
Salt stress has become a major environmental problem affecting plant growth and development. Some WRKY transcription factors have been reported to be involved in the salt response plants. However, there are few studies on involvement of WRKYs