A5034633496- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Cardiac Fibrosis and Remodeling
- Cancer Immunotherapy and Biomarkers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Neurogenetic and Muscular Disorders Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Chronic Myeloid Leukemia Treatments
- Cerebrovascular and Carotid Artery Diseases
- Biochemical Analysis and Sensing Techniques
- Immune Response and Inflammation
- 14-3-3 protein interactions
- Autophagy in Disease and Therapy
- Hippo pathway signaling and YAP/TAZ
- Axon Guidance and Neuronal Signaling
University of Mississippi Medical Center
2023-2024
Nanjing Drum Tower Hospital
2022-2024
Nanjing Medical University
2022-2024
Jiangsu Province Hospital
2023-2024
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2023-2024
Zhengzhou University
2024
Shenyang Pharmaceutical University
2024
State Street (United States)
2024
Janssen (Belgium)
2024
Nanjing University
2011-2023
Gut microbes participate in pathogenesis by interacting with the host genome through epigenetic mechanisms, such as long non-coding RNAs. However, mechanisms which microbiota induce expression alteration of RNAs remains unclear. Here, we quantified transcriptome human colon cell lines after being infected a common enteric pathogen Salmonella typhimurium SL1344 . We observed widespread lncRNAs alteration. Among them, elevated LINC00152 was verified and proved to be induced bacteria-derived...
The precise spatiotemporal control of cell proliferation is key to the morphogenesis epithelial tissues. Epithelial divisions lead tissue crowding and local changes in force distribution, which turn suppress rate divisions. However, molecular mechanisms underlying this mechanical feedback are largely unclear. Here, we identify a critical requirement B-plexin transmembrane receptors response crowding-induced forces during embryonic skin development. Epidermal stem cells lacking B-plexins fail...
Neoantigens are considered ideal targets for immunotherapy, especially tumor vaccine, because of their strong specificity and immunogenicity. Here, we developed a neoantigen nanovaccine used liposomes with lymph-node targeting characteristic.Our was composed neoantigens, an amphiphilic liposome adjuvant Montanide™ ISA 51. Small animal imaging system immunofluorescence staining were to identify the distribution nanovaccines. A subcutaneous-tumor-resection mouse model melanoma established...
Systemic lupus erythematosus (SLE), characterized by persistent inflammation, is a complex autoimmune disorder that affects all organs, challenging clinical treatment. Dysbiosis of gut microbiota promotes disorders damage extraintestinal organs. Modulating the microbiome proposed as promising approach for fine-running parts immune system, relieving systematic inflammation in multiple diseases. This study demonstrated administration Akkermansia muciniphila and Lactobacillus plantarum...
Objective To determine the association between preoperative Bioenergetic Health Index (BHI) of platelets and occurrence postoperative delirium (POD) in elderly patients. Methods Elderly patients scheduled for major abdominal surgery under general anesthesia were included. The presence POD was assessed within 3 days after surgery. Seahorse XF analysis transmission electron microscopy utilized to evaluate mitochondrial metabolism morphology platelets. Results A total 20 out 162 participants...
Crohn's disease is a common, chronic inflammatory bowel condition characterized by remission and relapse. Accumulating evidence indicates that activated T cells play an important role in this disease. In the present study, we aimed to examine effect of beauvericin, natural cyclic peptide, on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mice, which mimics Beauvericin significantly reduced weight loss, diarrhea mortality, accompanied with notable alleviation macroscopic...
Mesenchymal stem cell-derived extracellular vesicles (MSCs-EVs) possess cardioprotection in acute myocardial infarction. Nevertheless, the therapeutic intervention potential and molecular mechanism of EVs from NMN (Nicotinamide mononucleotide) preconditioned hUCMSCs (N-EVs) infarction remains unknown. In present study, (M-EVs) N-EVs were identified by electron microscopy, immunoblotting nanoparticle tracking analysis. Compared with M-EVs, significantly increased proliferation, migration,...
Abstract Background Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However, the systemic toxicity chemotherapy tumor immunosuppressive microenvironment limit clinical application. Methods Here, an injectable sodium alginate hydrogel (ALG) loaded with nanoparticle albumin-bound-paclitaxel (Nab-PTX) immunostimulating agent R837 was developed for local administration. Two murine hepatocellular carcinoma breast...
The mouse bitter taste receptors Tas2r143, Tas2r135 and Tas2r126 are encoded by genes that cluster on chromosome 6 have been suggested to be expressed under common regulatory elements. Previous studies indicated the Tas2r143/Tas2r135/Tas2r126 is in heart, but other organs had not systematically analyzed. In order investigate expression of this receptor gene nongustatory tissues, we generated a BAC (bacterial artificial chromosome) based transgenic line, expressing CreERT2 control Tas2r143...
Neoadjuvant chemoradiotherapy is the standard treatment for locally advanced rectal cancer, with modest benefits on tumor regression and survival. Since combined immune checkpoint inhibitors has been reported to have synergic effects. This study aims explore safety efficacy of long-course concurrent tislelizumab as a neoadjuvant regimen patients cancer. manuscript interim result prospective, multicenter, single-arm, phase II trial. Patients mid-to-low cancer clinical stages cT3-4a N0M0 or...
The p38 MAPK signaling pathway plays a pivotal role in inflammation. Targeting may be potential strategy for the treatment of inflammatory diseases. In present study, we show that novel chromone derivative, DCO-6, significantly reduced lipopolysaccharide (LPS)-induced production nitric oxide, IL-1β and IL-6, decreased levels iNOS, IL-6 mRNA expression both RAW264.7 cells mouse primary peritoneal macrophages, inhibited LPS-induced activation but not JNK, ERK. Moreover, DCO-6 specifically...
We report a genetically encoded fluorescent sensor for in vivo copper(I) imaging based on engineered intramolecular mechanical strain and structural distortion of EGFP.
Changes in bacteriome composition have a strong association with gastric cancer (GC). However, the relationship between stomach fungal microbiota and human host immune factors remains largely unknown. With high-throughput internal transcribed spacer region 2 (ITS2) sequencing, we characterized microbiome among GC ( n = 22), matched para-GC healthy individuals 11). A total of 4.5 million valid tags were generated stratified into 1,631 operational taxonomic units (OTUs), 10 phyla 301 genera...
Introduction Despite recent developments in our comprehension of how the gut microbiota and systemic lupus erythematosus (SLE) are related. The mycobiome: which is a small but crucial part involved hosts’ homeostasis physiological processes, remained unexplored SLE. Methods We profiled fungal mycobiota based on internal transcribed spacer region 1 (ITS1) sequencing for microbial DNA from SLE individuals with nephritis (LN) ( n = 23), without LN 26) healthy controls 14) enrolled Nanjing Drum...
This study aims to explore the regulatory effect of S-ketamine on mechanical allodynia, anxiety-like behaviors and microglia activation in adult male rats exposed an animal model post-traumatic stress disorder (PTSD). The rat PTSD was established by exposure single-prolonged (SPS), 1 day later, were intraperitoneally injected with 5 mg/kg or normal saline, respectively. Paw withdrawal threshold measured 2 days before, 1, 3, 5, 7, 10, 14, 21 28 after injection assess allodynia SPS-exposed...
Selenium (Se) deficiency is associated with the development of Keshan disease, a cardiomyopathy massive cardiac immune cell infiltration that can lead to heart failure (HF). The purpose this study was determine whether high Se diet attenuate systolic overload-induced cardiopulmonary inflammation and HF. Briefly, transverse aortic constriction (TAC)-induced oxidative stress, inflammation, left ventricular (LV) dysfunction, pulmonary remodeling were determined in male mice fed either or normal...
Phosphatase of regenerating liver 3 (PRL-3) is known to be overexpressed in many tumors, and its transcript level high the vasculature endothelial cells malignant tumor tissue. However, mechanism(s) underlying enhanced expression function remain unknown. Here, we report that vascular growth factor (VEGF) can induce PRL-3 transcription human umbilical vein (HUVEC). An analysis 5′UTR revealed initiated from two distinct sites, which results formation transcripts, PRL-3-iso1 PRL-3-iso2, but...
IL-12α plays an important role in modulating inflammatory response, fibroblast proliferation and angiogenesis through macrophage polarization or T cell function, but its effect on cardiorespiratory fitness is not clear. Here, we studied the of cardiac inflammation, hypertrophy, dysfunction, lung remodeling gene knockout (KO) mice response to chronic systolic pressure overload produced by transverse aortic constriction (TAC). Our results showed that KO significantly ameliorated TAC-induced...
Aberrant proliferation, migration, and apoptosis of vascular smooth muscle cells (VSMCs) are major pathological phenomenon in hypertension. MicroRNAs (miRNAs/miRs) serve crucial roles the progression We aimed to determine role miR-96-5p VSMCs its underlying mechanisms.Angiotensin II (Ang II) was employed treat VSMCs, expression detected by RT-qPCR. Then, mimic transfected into VSMCs. Cell Counting Kit-8 assay, flow cytometry, transwell wound healing assay were applied measure cell cycle,...