A5017777839- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Anorectal Disease Treatments and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Clinical practice guidelines implementation
- Cardiac, Anesthesia and Surgical Outcomes
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Ionic liquids properties and applications
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Enhanced Recovery After Surgery
- Venous Thromboembolism Diagnosis and Management
National Clinical Research Center for Digestive Diseases
2017-2025
Capital Medical University
2017-2025
Beijing Friendship Hospital
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Soochow University
2014-2025
The University of Texas Southwestern Medical Center
2022-2025
University of Shanghai for Science and Technology
2024-2025
Wenzhou Medical University
2025
Ministry of Education of the People's Republic of China
2025
Capital University
2023-2024
Mesenchymal stem cells (MSCs) have been recognized as a cell therapy with the potential to promote skin healing. MSCs, their multipotent differentiation ability, can generate various related wound healing, such dermal fibroblasts (DFs), endothelial cells, and keratinocytes. In addition, MSCs neovascularization, cellular regeneration, tissue healing through mechanisms including paracrine autocrine signaling. Due these characteristics, extensively studied in context of burn chronic repair....
Adding PD-1 blockade in the neoadjuvant regimens for locally advanced rectal cancer (LARC) patients with microsatellite stable (MSS) / mismatch repair-proficient (pMMR) tumors is an attractive, but debatable strategy. This phase 2, multicenter, prospective, single-arm study enrolled from 6 centers June 2021 to November 2022. Locally (LARC, cT
It has been confirmed that commonly used ionic liquids are not easily biodegradable. When ultimately disposed of or accidentally released, they would accumulate in the environment, which strongly restricts large-scale industrial applications liquids. Herein, ten biodegradable were prepared by a single, one-pot neutralization choline and surrogate naphthenic acids. The structures these acid (NAILs) characterized (1)H (13)C NMR spectroscopy, IR elemental analysis, their physical properties,...
MRI is the gold standard for confirming a pelvic lymph node metastasis diagnosis. Traditionally, medical radiologists have analyzed image features of regional nodes to make diagnostic decisions based on their subjective experience; this diagnosis lacks objectivity and accuracy. This study trained faster region-based convolutional neural network (Faster R-CNN) with 28,080 images metastasis, allowing Faster R-CNN read those diagnoses. For clinical verification, 414 cases rectal cancer at...
PURPOSE Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The controversy mainly regarding survival benefit from extended lymph node dissection emphasized by CME. METHODS This multicenter, open-label, randomized controlled trial (ClinicalTrials.gov identifier: NCT02619942 ) was performed across 17 hospitals in China....
Abstract Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is an innovative therapeutic strategy for (CRC) patients with poor prognosis and relapse. However, context-dependent traits CRCSCs remain poorly elucidated. Here we report that adenylate kinase hCINAP overexpressed in CRC tissues. Depletion inhibits invasion, self-renewal, tumorigenesis chemoresistance a loss mesenchymal signature. Mechanistically, binds to C-terminal domain LDHA, key regulator...
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic lung characterized by abnormal inflammation, persistent and progressive function decline. The anti-inflammatory actions of tanshinone IIA, which the most important active component from Chinese herbal medicine Danshen, have been well studied. However, it remains unknown whether sodium IIA sulfonate (STS) protects against development COPD. Here we found that STS inhalation (5 mg/kg, 30 min per session, twice day) significantly...
Characterization, diagnosis, and treatment of colorectal cancers (CRC) is difficult due to limited biopsy information, impracticality repeated biopsies, cancer biomarker fallibility. Circulating tumor DNA (ctDNA) has recently been investigated as a non-invasive way gain representative gene mutations in tumors, addition monitoring disease progression response treatment. We analyzed ctDNA concentrations 47 early- late-stage CRC patients using targetted sequencing approach panel that covers 50...
Vascular endothelial growth factor (VEGF) induces phosphorylation of VEGF receptor-2 (VEGFR-2) and activates the downstream signaling pathway resulting in cell migration, proliferation, survival. Cigarette smoking is associated with abnormal vascular function, leading to airspace enlargement. Herein, we investigated mechanism cigarette smoke (CS) -induced dysfunction by studying VEGF-VEGFR-2 mouse lung human cells. CS exposure caused oxidative stress, as shown increased levels...
The densities and viscosities of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM][NTf2]) + N-methyl-2-pyrrolidone (NMP) [EMIM][NTf2] ethanol mixtures were investigated over the mole fraction range from (0.1 to 0.9) at temperatures (293.15 323.15) K intervals 5 K. can be well-represented by quadratic equation, represented in form Vogel equation. excess molar volumes (VE) viscosity deviations (Δη) calculated, results fitted Redlich–Kister equation using a multiparametric...
In this retrospective analysis, we evaluated associations between albumin to globulin ratio (AGR), clinicopathological characteristics, and survival in 592 patients with localized or locally advanced clear cell renal carcinoma (CCRCC) prior nephrectomy. We found that low AGR was associated more aggressive tumor behavior; had poorer overall (OS) cancer-specific (CSS) Kaplan-Meier analyses both before after propensity score matching, which used compensate for differences baseline...
Transforming growth factor beta-induced protein (TGFBI) is an extracellular matrix induced by TGF-β. Previous studies have reported that the abnormal expression of TGFBI related to occurrence and development some types cancers, while role in glioma uncertain.The association between prognosis patients with was analyzed based on data obtained from The Cancer Genome Atlas database. 3 normal human brains 57 cases gliomas immunohistochemistry followed evaluation relationships clinic-pathological...
Background: An artificial intelligence system of Faster Region-based Convolutional Neural Network (Faster R-CNN) is newly developed for the diagnosis metastatic lymph node (LN) in rectal cancer patients. The primary objective this study was to comprehensively verify its accuracy clinical use. Methods: Four hundred fourteen patients with discharged between January 2013 and March 2015 were collected from 6 centers, magnetic resonance imaging data pelvic LNs each patient identified by R-CNN....
Metastasis is the most challenging issue for gastric cancer, and identification of molecular mechanism suitable targets treatment major purpose recent research. In this study, we found long non-coding RNA ANRIL was critical progression cancer. Knockdown (also known as CDKN2B-AS) with shRNA increased apoptosis, inhibited tumor growth, suppressed migration cancer cells. TET2 (Tet Methylcytosine Dioxygenase 2), a methylcytosine dioxygenase function prevented progression. Patients higher...
Our goal is to analyze the trend of colorectal cancer (CRC) regarding death, incidence and prevalence rates over time, provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes CRC in 2017 those 1990, which was extracted from Global Burden Disease (GBD).The time changes burden 1990 were measured using methods results Institute Health Metrics Evaluation (IHME) GBD 2017, based on prevalence.The death rate 13.24/100,000, accounting 1.79% total...