A5020526638- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
University of Birmingham
2024-2025
University of Bristol
2020-2021
The amplitudes of small-modifier protein signaling through ubiquitin and the small ubiquitin-like modifiers, SUMO1-3, are critical to correct phasing DNA repair accumulation, activity, clearance for completion mammalian double-strand-break (DSB) repair. However, how SUMO-conjugate in response is delineated poorly understood. At same time, role non-conjugated SUMO protein, SUMO4, has remained enigmatic. Here, we reveal that human SUMO4 required prevent excessive DNA-damage-induced SUMOylation...
Wilms tumour (WT), an embryonal kidney cancer, has been extensively characterised for genetic and epigenetic alterations, but a proportion of WTs still lack identifiable abnormalities. To uncover DNA methylation changes critical WT pathogenesis, we compared the epigenome foetal with two cell lines, filtering our results to remove common cancer‐associated enrich genes involved in early development. This identified four hypermethylated genes, which ESRP2 (epithelial splicing regulatory protein...
Abstract Mammalian DNA replication relies on various helicase and nuclease activities to ensure accurate genetic duplication, but how different are properly directed remains unclear. Here, we identify the ubiquitin-specific protease, USP50, as a chromatin-associated protein required promote ongoing replication, fork restart, telomere maintenance, cellular survival following hydroxyurea or pyridostatin treatment, suppression of breaks near GC-rich sequences. We find that USP50 supports proper...
ABSTRACT Wilms tumour (WT), a childhood kidney cancer with embryonal origins, has been extensively characterised for genetic and epigenetic alterations, but proportion of WTs still lack identifiable abnormalities. To uncover DNA methylation changes critical WT pathogenesis, we compared the epigenome fetal two cell lines, using methyl-CpG immunoprecipitation. We filtered our results to remove common cancer-associated changes, enrich genes involved in early development. This identified four...
Abstract The amplitudes of small-modifier protein signalling through ubiquitin and the Small Ubiquitin-like Modifiers, SUMO1-3, are critical to correct phasing DNA repair accumulation, activity, clearance, for completion mammalian double-strand break (DSB) repair. However, how SUMO-conjugate in response is delineated poorly understood. At same time, role non-conjugated SUMO protein, SUMO4, has remained enigmatic. Here we reveal that SUMO4 required prevent excessive DNA-damage-induced...