Paul Anantharajah Tambyah
A5041779107- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Viral Infections and Outbreaks Research
- Long-Term Effects of COVID-19
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Infective Endocarditis Diagnosis and Management
- Nosocomial Infections in ICU
- Viral gastroenteritis research and epidemiology
- Infection Control and Ventilation
- Animal Disease Management and Epidemiology
- Zoonotic diseases and public health
- Infection Control in Healthcare
National University of Singapore
2016-2025
National University Health System
2016-2025
National University Hospital
2016-2025
National Centre for Infectious Diseases
2008-2024
Translational Research Institute
2024
International Society for Infectious Diseases
2020-2023
National University Heart Centre Singapore
2022-2023
World Health Organization Regional Office for the Western Pacific
2021-2022
Weatherford College
2021-2022
Tan Tock Seng Hospital
2008-2022
<h3>Importance</h3> Extended-spectrum β-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in<i>Escherichia coli</i>and<i>Klebsiella pneumoniae.</i>Significant infections caused by these strains are usually treated with carbapenems, potentially selecting for carbapenem resistance. Piperacillin-tazobactam may be an effective "carbapenem-sparing" option treat extended-spectrum β-lactamase producers. <h3>Objectives</h3> To determine whether definitive therapy...
BackgroundThe Global Point Prevalence Survey (Global-PPS) established an international network of hospitals to measure antimicrobial prescribing and resistance worldwide. We aimed assess in hospital inpatients.MethodsWe used a standardised surveillance method collect detailed data about from worldwide, which were grouped by UN region. The internet-based survey included all inpatients (adults, children, neonates) receiving who on the ward at 0800 h one specific day between January September,...
<h3>Background</h3> Catheter-associated urinary tract infection (CAUTI) is the most common nosocomial infection, accounting for more than 1 million cases each year in US hospitals and nursing homes. <h3>Objective</h3> To define clinical features of CAUTI. <h3>Setting Patients</h3> A university hospital; 1497 newly catheterized patients. <h3>Design</h3> Every day that catheter was place, a quantitative urine culture leukocyte count were obtained, patient queried by research worker regarding...
The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2–specific individuals who clear SARS-CoV-2 without symptoms could reveal nonpathological yet protective characteristics. We longitudinally studied cohort asymptomatic (n = 85) symptomatic 75) COVID-19 patients after seroconversion. quantified reactive to structural proteins (M, NP, Spike) using ELISpot cytokine secretion whole blood. Frequencies were...
Abstract Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthralgia in humans. To date, interactions between the immune system different stages of life cycle remain poorly defined. We demonstrated for first time CHIKV Ags could be detected vivo monocytes acutely infected patients. Using vitro experimental systems, whole blood purified monocytes, we confirmed growth sustained. with other leukocytes, induced a robust rapid innate response production specific...
Abstract Background Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) superspreading events suggest that aerosols play an important role in driving the disease 2019 (COVID-19) pandemic. To better understand how airborne SARS-CoV-2 transmission occurs, we sought to determine viral loads within coarse (&gt;5 μm) and fine (≤5 produced when breathing, talking, singing. Methods Using a G-II exhaled breath collector, measured RNA emitted by COVID-19 patients during 30...
Key knowledge gaps remain in the understanding of viral dynamics and immune response Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection.We evaluated these characteristics established their association with clinical severity a prospective observational cohort study 100 patients PCR-confirmed SARS-CoV-2 infection (mean age, 46 years; 56% male; 38% comorbidities). samples (n = 74) were collected for culture, serum measurement IgM/IgG levels 30), plasma inflammatory cytokines...
BackgroundCarbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the distribution and clinical significance of carbapenemases are unclear. The aim this study was to define characteristics outcomes CRPA infections frequency impact harboured by CRPA.MethodsWe conducted an observational, prospective cohort isolated from bloodstream, respiratory, urine, or wound cultures patients at 44 hospitals (10 countries) between Dec 1, 2018, Nov 30, 2019. Clinical data were abstracted...
Numerous reports of vascular events after an initial recovery from COVID-19 form our impetus to investigate the impact on health recovered patients. We found elevated levels circulating endothelial cells (CECs), a biomarker injury, in convalescents compared healthy controls. In particular, those with pre-existing conditions (e.g., hypertension, diabetes) had more pronounced activation hallmarks than non-COVID-19 patients matched cardiovascular risk. Several proinflammatory and activated T...
The complications and sequelae of coronavirus disease 2019 (COVID-19) their effect on long-term health are unclear, the trajectory associated immune dysregulation is poorly understood.We conducted a prospective longitudinal multicenter cohort study at 4 public hospitals in Singapore. Patients with COVID-19 were monitored for median 6 months after recovery from acute infection. Clinical symptoms radiologic data collected, along plasma samples quantification mediators. relationship between...