A5085958612- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Infection Control in Healthcare
- Mycobacterium research and diagnosis
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Antifungal resistance and susceptibility
- COVID-19 and Mental Health
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Enterobacteriaceae and Cronobacter Research
- Patient Satisfaction in Healthcare
- Nosocomial Infections in ICU
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- Streptococcal Infections and Treatments
- Viral Infections and Outbreaks Research
- Disaster Response and Management
Tan Tock Seng Hospital
2016-2025
Nanyang Technological University
2015-2025
National Centre for Infectious Diseases
2012-2025
National University of Singapore
1992-2025
Museum of Heilongjiang Province
2021
Imperial College London
2020
José Rizal University
2019
Office of Infectious Diseases
2017
Infectious Diseases Institute
2017
Singapore General Hospital
1991-2016
Abstract Understanding the particle size distribution in air and patterns of environmental contamination SARS-CoV-2 is essential for infection prevention policies. Here we screen surface samples from hospital rooms COVID-19 patients RNA. Environmental sampling conducted three airborne isolation (AIIRs) ICU 27 AIIRs general ward. 245 are collected. 56.7% have at least one contaminated. High touch shown ten (66.7%) out 15 first week illness, (20%) beyond illness ( p = 0.01, χ 2 test). Air...
BackgroundRapid identification of COVID-19 cases, which is crucial to outbreak containment efforts, challenging due the lack pathognomonic symptoms and in settings with limited capacity for specialized nucleic acid–based reverse transcription polymerase chain reaction (PCR) testing.
Key knowledge gaps remain in the understanding of viral dynamics and immune response Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection.We evaluated these characteristics established their association with clinical severity a prospective observational cohort study 100 patients PCR-confirmed SARS-CoV-2 infection (mean age, 46 years; 56% male; 38% comorbidities). samples (n = 74) were collected for culture, serum measurement IgM/IgG levels 30), plasma inflammatory cytokines...
Severe acute respiratory syndrome (SARS) is an emerging viral infectious disease. One of the largest outbreaks SARS to date began in Singapore March 2003. We describe clinical, laboratory, and radiologic features index patient patient's initial contacts affected with probable SARS.
We conducted a national point prevalence survey (PPS) to determine the of healthcare-associated infections (HAIs) and antimicrobial use (AMU) in Singapore acute-care hospitals.Trained personnel collected HAI, AMU, baseline hospital- patient-level data adult inpatients from 13 private public hospitals between July 2015 February 2016, using PPS methodology developed by European Centre for Disease Prevention Control. Factors independently associated with HAIs were determined multivariable...
Abstract Understanding the particle size distribution in air and patterns of environmental contamination SARS-CoV-2 is essential for infection prevention policies. We aimed to detect surface study associated patient-level factors. 245 samples were collected from 30 airborne isolation rooms COVID-19 patients, sampling was conducted 3 rooms. Air detected PCR-positive particles sizes >4 µm 1-4 two rooms, which warrants further transmission potential SARS-CoV-2. 56.7% had at least one...
Abstract Background Coronavirus disease 2019 (COVID-19) is an emerging infectious caused by a novel coronavirus (SARS-CoV-2) and first reported in Wuhan, China, December 2019. Since the severe acute respiratory syndrome (SARS) outbreak 2003, Tan Tock Seng Hospital (TTSH) Singapore has routinely fit-tested staff for high-filtration N95 respirators established Web-based surveillance systems. The routine systems were enhanced response to Singapore’s imported COVID-19 case on 23 January 2020....
Importance In September 2023, the Singapore Ministry of Health revised national personal protective equipment (PPE) guideline for health care personnel (HCP) attending to suspected or confirmed patients with COVID-19, recommending use N95 respirators alone. However, data on associations between PPE deescalation, staff COVID-19 incidence, and sustainability outcomes are limited. Objective To evaluate deescalation guidelines incidence environmental measure. Design, Setting, Participants This...
This report describes a graduate student in microbiology Singapore whom fever and respiratory symptoms led to the diagnosis of infection with severe acute syndrome (SARS) virus September 2003. The had worked vial West Nile virus, but an epidemiologic investigation found SARS contaminating vial.
The purpose of this study was to characterize the presentations, long-term outcomes, and visual prognostic factors in dengue-related maculopathy 41 patients with dengue fever impaired vision from a retrospective noninterventional observational series.The medical records diagnosed over 18 months between July 2004 December 2005 at Eye Institute, Tan Tock Seng Hospital Communicable Disease Center, Singapore, were reviewed followed up for 24 months. Visual acuity symptoms (presence scotoma on...
Abstract Objectives To evaluate the safety and clinical outcomes of patients who received carbapenem de-escalation as guided by an antimicrobial stewardship programme (ASP) in a setting where ESBL-producing Enterobacteriaceae are endemic. Methods Patients receiving meropenem or imipenem underwent prospective ASP review for eligibility according to defined institutional guidelines. whom was de-escalated not de-escalated, representing acceptance rejection recommendation, respectively, were...
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the 'Save PDF' action button.
Surgical site infection (SSI) is a common and preventable complication of surgery, but the relative importance individual measures recommended by guidelines has not been determined. Elective general surgical, neurological, orthopedic procedures requiring antibiotic prophylaxis from 3-month period were retrospectively studied to determine concordance with SSI prevention identify factors which predicted development SSIs. A total 216 surgeries reviewed, 18 SSIs (8.3%). mean 1.4 errors per...
Abstract Surveillance of nosocomial infections, like catheter-associated urinary tract infection (CAUTI), central line-associated bloodstream infection, possible ventilator-associated pneumonia and secondary infections were observed to study the impact COVID-19 outbreak in ICUs from Tan Tock Seng Hospital National Centre for Infectious Diseases, Singapore between February June 2020. Higher rates patients, although it was not statistically significant. Moreover, patients seem be more...
Abstract Background Prolonged fever is associated with adverse outcomes in dengue viral infection. Similar patterns are observed COVID-19 unclear significance. Methods We conducted a hospital-based case–control study of patients admitted for prolonged (fever >7 days) and saddleback (recurrence fever, lasting <24 hours, after defervescence beyond day 7 illness). Fever was defined as temperature ≥38.0°C. Cytokines were determined multiplex microbead-based immunoassay subgroup...
Abstract Background The transmission of carbapenemase-producing organisms (CPO) in healthcare facilities is associated with increased morbidity and mortality. Recommended control measures include early detection asymptomatic carriers coupled isolation contact precautions. Such can be costly need to balanced against the disruption hospital operations. We assessed effectiveness different screening strategies at averting potential CPO infections corresponding cost savings. Methods A basic...
Abstract Background Tan Tock Seng Hospital is a 1700-bed academic teaching hospital in Singapore. Active surveillance using rapid PCR for the detection of asymptomatic carriage carbapenemase-producing organisms (CPO) routinely performed (Fig. 1). Where available, identified carriers are cohorted or isolated under contact precautions. We describe hospital-wide multispecies OXA-48-like and NDM outbreak, findings from epidemiological investigations subsequent infection prevention control (IPC)...
We present a case of 46-year-old male with disseminated melioidosis. He initially presented primary bacteremia but eventually developed recrudescent infection characterized by meningo-rhombencephalitis, as well pulmonary and splenic abscesses. This was attributed to the emergence carbapenem resistance, which while he receiving parenteral antibiotic therapy. The patient improved after switching his antibiotics combination ceftazidime trimethoprim-sulfamethoxazole. development resistance in...