A5028009336- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- Long-Term Effects of COVID-19
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Nail Diseases and Treatments
- Fungal Infections and Studies
- COVID-19 and healthcare impacts
- Antifungal resistance and susceptibility
- Retinal and Optic Conditions
- Infection Control and Ventilation
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Viral-associated cancers and disorders
- Antibiotic Use and Resistance
- Machine Learning in Healthcare
- Clostridium difficile and Clostridium perfringens research
- Listeria monocytogenes in Food Safety
- Salmonella and Campylobacter epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Gastrointestinal motility and disorders
- Infection Control in Healthcare
- Vascular Procedures and Complications
- Viral Infections and Vectors
Tan Tock Seng Hospital
2018-2025
National Centre for Infectious Diseases
2018-2024
National University Health System
2021-2024
Changi General Hospital
2020
National Cancer Centre Singapore
2013
Abstract Understanding the particle size distribution in air and patterns of environmental contamination SARS-CoV-2 is essential for infection prevention policies. Here we screen surface samples from hospital rooms COVID-19 patients RNA. Environmental sampling conducted three airborne isolation (AIIRs) ICU 27 AIIRs general ward. 245 are collected. 56.7% have at least one contaminated. High touch shown ten (66.7%) out 15 first week illness, (20%) beyond illness ( p = 0.01, χ 2 test). Air...
BackgroundRapid identification of COVID-19 cases, which is crucial to outbreak containment efforts, challenging due the lack pathognomonic symptoms and in settings with limited capacity for specialized nucleic acid–based reverse transcription polymerase chain reaction (PCR) testing.
Key knowledge gaps remain in the understanding of viral dynamics and immune response Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection.We evaluated these characteristics established their association with clinical severity a prospective observational cohort study 100 patients PCR-confirmed SARS-CoV-2 infection (mean age, 46 years; 56% male; 38% comorbidities). samples (n = 74) were collected for culture, serum measurement IgM/IgG levels 30), plasma inflammatory cytokines...
To investigate the prevalence and epidemiological risk factors of olfactory and/or taste disorder (OTD), in particular isolated OTD, patients with laboratory-confirmed COVID-19 infection. We conducted a retrospective cross-sectional study. Patients infection were recruited from National Centre for Infectious Diseases (NCID) Singapore between 24 March 2020 16 April 2020. The electronic health records these accessed, demographic data symptoms reported (respiratory, self-reported OTD other such...
Abstract Background Tan Tock Seng Hospital is a 1700-bed academic teaching hospital in Singapore. Active surveillance using rapid PCR for the detection of asymptomatic carriage carbapenemase-producing organisms (CPO) routinely performed (Fig. 1). Where available, identified carriers are cohorted or isolated under contact precautions. We describe hospital-wide multispecies OXA-48-like and NDM outbreak, findings from epidemiological investigations subsequent infection prevention control (IPC)...
The performance of real-time reverse transcription polymerase chain reaction (rRT-PCR) for SARS-CoV-2 varies with sampling site(s), illness stage, and infection site.Unilateral nasopharyngeal, nasal midturbinate, throat swabs, saliva were simultaneously sampled rRT-PCR from suspected or confirmed cases COVID-19. True positives defined as patients at least 1 detected by any site on the evaluation day time point thereafter, until discharge. Diagnostic was assessed extrapolated combinations.We...
Abstract We aim to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. This was multicentered prospective study with clinical laboratory details. Details for fifty uncomplicated ten who required mechanical ventilation were collected. compared features between the groups, assessed predictors intubation, described ventilatory management ICU patients. Ventilated significantly older, reported more dyspnea, had elevated C-reactive protein lactate...
The first autochthonous Zika virus (ZIKV) outbreak in Singapore was detected August 2016. We report an analysis of the correlation clinical illness with viremia and laboratory parameters this Asian cohort.We conducted a prospective longitudinal cohort study patients positive blood ZIKV polymerase chain reaction (PCR) result who were admitted to Tan Tock Seng Hospital, Singapore, for isolation management.We included 40 our study. Rash present all patients, while 80% (32/40) had fever, 62.5%...
To report bilateral follicular conjunctivitis in two confirmed Coronavirus (COVID-19) patients with the presence of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) conjunctival swab specimens. Two unrelated SARS-CoV-2 infection and acute were examined. Conjunctival swabs assessed for by quantitative real-time polymerase chain reaction (RT-PCR) viral culture. Both developed eye redness 3 days after onset COVID-19 symptoms. Slit lamp examination showed conjunctivitis, which was...
We describe 3 COVID-19 patients with acute near vision difficulty. Case 1, a 46-year-old man, presented severe, generalized headache, fever, sore throat, anosmia, dysgeusia, and chest discomfort. The following day, nasopharyngeal swab for SARS-CoV-2 reverse transcriptase polymerase chain reaction was positive. He then noticed difficulty reading his quarantine documents. had no other visual, neurological, or dysautonomic complaints. His pupil sizes were mm bilaterally anisocoria in light...
We read with great interest the recent review article in ESMO Gastrointestinal Oncology by T. E. Kroese et al., which presents an update on recommendations oligometastatic disease esophagogastric cancer as defined Oligometastatic Esophagogastric Cancer (OMEC) project. As biology of cancers becomes better known, identifying patients oligometastases from who may benefit more invasive therapies is urgent and unmet need. The efforts to propose a uniform classification noteworthy will certainly...
Case identification is an ongoing issue for the COVID-19 epidemic, in particular outpatient care where physicians must decide which patients to prioritise further testing. This paper reports tools classify based on symptom profiles 236 severe acute respiratory syndrome coronavirus 2 positive cases and 564 controls, accounting time course of illness using generalised multivariate logistic regression. Significant symptoms included abdominal pain, cough, diarrhoea, fever, headache, muscle ache,...
Abstract Case identification is an ongoing issue for the COVID-19 epidemic, in particular outpatient care where physicians must decide which patients to prioritise further testing. This paper reports tools classify based on symptom profiles 236 SARS-CoV-2 positive cases and 564 controls, accounting time course of illness at point assessment. Clinical differentiators controls were used derive model-based risk scores. Significant symptoms included abdominal pain, cough, diarrhea, fever,...
Serial galactomannan (GM) monitoring can aid the diagnosis of invasive aspergillosis (IA) and optimise treatment decisions. However, widespread adoption mould-active prophylaxis has reduced incidence IA challenged its use. We evaluated cost-effectiveness prophylaxis-biomarker strategies. A Markov model simulating high-risk patients undergoing routine GM surveillance with versus non-mould-active was constructed. The incremental cost for each additional quality-adjusted life-year (QALY) gained...
Learning points for cliniciansMycotic aneurysms are a rare, but potentially devastating complication of invasive Group A Streptococcal infections.Prompt recognition and initiation appropriate antimicrobial therapy critical.Good outcomes have been reported with endovascular aneurysm repair.Duration antibiotics is often prolonged, up to 6 weeks or longer in most cases.